Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-24T13:52:14.176Z Has data issue: false hasContentIssue false
  • English
  • Français

Alcohol-use disorder severity predicts first-incidence of depressive disorders

Published online by Cambridge University Press:  26 August 2011

L. Boschloo ,
W. van den Brink ,
B. W. J. H. Penninx ,
M. M. Wall  and
D. S. Hasin
L. Boschloo
Affiliation:
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
W. van den Brink
Affiliation:
Academic Medical Center University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands
B. W. J. H. Penninx
Affiliation:
Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands EMGO+ Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
M. M. Wall
Affiliation:
Mailman School of Public Health, Department of Epidemiology, Columbia University, New York, NY 10032, USA College of Physicians and Surgeons, Department of Psychiatry, Columbia University, New York, NY 10032, USA
D. S. Hasin*
Affiliation:
Mailman School of Public Health, Department of Epidemiology, Columbia University, New York, NY 10032, USA College of Physicians and Surgeons, Department of Psychiatry, Columbia University, New York, NY 10032, USA New York State Psychiatric Institute, New York, NY 10032, USA
*
*Address for correspondence: D. S. Hasin, PhD, Columbia University, College of Physicians & Surgeons, 1051 Riverside Drive #123, New York, New York 10032, USA. (Email: [email protected])
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Previous studies suggest that alcohol-use disorder severity, defined by the number of criteria met, provides a more informative phenotype than dichotomized DSM-IV diagnostic measures of alcohol use disorders. Therefore, this study examined whether alcohol-use disorder severity predicted first-incident depressive disorders, an association that has never been found for the presence or absence of an alcohol use disorder in the general population.

Method

In a national sample of persons who had never experienced a major depressive disorder (MDD), dysthymia, manic or hypomanic episode (n=27 571), we examined whether a version of DSM-5 alcohol-use disorder severity (a count of three abuse and all seven dependence criteria) linearly predicted first-incident depressive disorders (MDD or dysthymia) after 3-year follow-up. Wald tests were used to assess whether more complicated models defined the relationship more accurately.

Results

First-incidence of depressive disorders varied across alcohol-use disorder severity and was 4.20% in persons meeting no alcohol-use disorder criteria versus 44.47% in persons meeting all 10 criteria. Alcohol-use disorder severity significantly predicted first-incidence of depressive disorders in a linear fashion (odds ratio 1.14, 95% CI 1.06–1.22), even after adjustment for sociodemographics, smoking status and predisposing factors for depressive disorders, such as general vulnerability factors, psychiatric co-morbidity and subthreshold depressive disorders. This linear model explained the relationship just as well as more complicated models.

Conclusions

Alcohol-use disorder severity was a significant linear predictor of first-incident depressive disorders after 3-year follow-up and may be useful in identifying a high-risk group for depressive disorders that could be targeted by prevention strategies.

Keywords

Alcohol use disordersdepressive disordersDSM-5NESARCseverity
Type
Original Articles
Information
Psychological Medicine , Volume 42 , Issue 4 , April 2012 , pp. 695 - 703
Copyright
Copyright © Cambridge University Press 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Beseler, CL, Hasin, DS (2010). Cannabis dimensionality: dependence, abuse and consumption. Addictive Behaviors 35, 961–969.CrossRefGoogle ScholarPubMed
Bromberger, JT, Kravitz, HM, Matthews, K, Youk, A, Brown, C, Feng, W (2009). Predictors of first lifetime episodes of major depression in midlife women. Psychological Medicine 39, 55–64.CrossRefGoogle ScholarPubMed
Burns, L, Teesson, M, O'Neill, K (2005). The impact of comorbid anxiety and depression on alcohol treatment outcomes. Addiction 100, 787–796.CrossRefGoogle ScholarPubMed
Chatterji, S, Saunders, JB, Vrasti, R, Grant, BF, Hasin, D, Mager, D (1997). Reliability of the alcohol and drug modules of the Alcohol Use Disorder and Associated Disabilities Interview Schedule-Alcohol/Drug-Revised (AUDADIS-ADR): an international comparison. Drug and Alcohol Dependence 47, 171–185.CrossRefGoogle ScholarPubMed
Cohen, P, Cohen, J (1984). The clinician's illusion. Archives of General Psychiatry 41, 1178–1182.CrossRefGoogle ScholarPubMed
Cottler, LB, Grant, BF, Blaine, J, Mavreas, V, Pull, C, Hasin, DS, Compton, WM, Rubio-Stipec, M, Mager, D (1997). Concordance of DSM-IV alcohol and drug use disorder criteria and diagnoses as measured by AUDADIS-ADR, CIDI and SCAN. Drug and Alcohol Dependence 47, 195–205.CrossRefGoogle ScholarPubMed
Dawson, DA, Grant, BF (2010). Should symptom frequency be factored into scalar measures of alcohol use disorder severity? Addiction 105, 1568–1579.CrossRefGoogle ScholarPubMed
Dawson, DA, Saha, TD, Grant, BF (2010). A multidimensional assessment of the validity and utility of alcohol use disorder severity as determined by item response theory models. Drug and Alcohol Dependence 107, 31–38.CrossRefGoogle ScholarPubMed
de Graaf, R, Bijl, RV, Ravelli, A, Smit, F, Vollebergh, WAM (2002). Predictors of first incidence of DSM-III-R psychiatric disorders in the general population: findings from the Netherlands Mental Health Survey and Incidence Study. Acta Psychiatrica Scandinavica 106, 303–313.CrossRefGoogle ScholarPubMed
Fergusson, DM, Boden, JM, Horwood, LJ (2009). Tests of causal links between alcohol abuse or dependence and major depression. Archives of General Psychiatry 66, 260–266.CrossRefGoogle ScholarPubMed
Grant, BF, Dawson, DA, Stinson, FS, Chou, PS, Kay, W, Pickering, R (2003). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample. Drug and Alcohol Dependence 71, 7–16.CrossRefGoogle Scholar
Grant, BF, Goldstein, RB, Chou, SP, Huang, B, Stinson, FS, Dawson, DA, Saha, TD, Smith, SM, Pulay, AJ, Pickering, RP, Ruan, WJ, Compton, WM (2009). Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. Molecular Psychiatry 14, 1051–1066.CrossRefGoogle ScholarPubMed
Grant, BF, Harford, TC, Dawson, DA, Chou, PS, Pickering, RP (1995). The Alcohol Use Disorder and Associated Disabilities Interview schedule (AUDADIS): reliability of alcohol and drug modules in a general population sample. Drug and Alcohol Dependence 39, 37–44.CrossRefGoogle Scholar
Grant, BF, Kaplan, KK, Stinson, FS (2007). Source and Accuracy Statement: The Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. National Institute on Alcohol Abuse and Alcoholism: Bethesda, MD.Google Scholar
Grant, BF, Moore, TC, Shepard, J, Kaplan, K (2001). Source and Accuracy Statement: The Wave 1 National Epidemiologic Survey on Alcohol and Related Conditions. National Institute on Alcohol Abuse and Alcoholism: Bethesda, MD.Google Scholar
Hasin, DS (2003). Classification of alcohol use disorders. Alcohol Research & Health 27, 5–17.Google ScholarPubMed
Hasin, DS, Beseler, CL (2009). Dimensionality of lifetime alcohol abuse, dependence and binge drinking. Drug and Alcohol Dependence 101, 53–61.CrossRefGoogle ScholarPubMed
Hasin, DS, Carpenter, KM, McCloud, S, Smith, M, Grant, BF (1997 a). The alcohol use disorder and associated disabilities interview schedule (AUDADIS): reliability of alcohol and drug modules in a clinical sample. Drug and Alcohol Dependence 44, 133–141.CrossRefGoogle Scholar
Hasin, DS, Goodwin, RD, Stinson, FS, Grant, BF (2005). Epidemiology of Major Depressive Disorder: Results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Archives of General Psychiatry 62, 1097–1106.CrossRefGoogle ScholarPubMed
Hasin, DS, Grant, BF (2002). Major depression in 6050 former drinkers. Archives of General Psychiatry 59, 794–800.CrossRefGoogle ScholarPubMed
Hasin, DS, Liu, X, Alderson, D, Grant, BF (2006 a). DSM-IV alcohol dependence: a categorical or dimensional phenotype? Psychological Medicine 36, 1695–1705.CrossRefGoogle ScholarPubMed
Hasin, DS, Samet, S, Nunes, E, Meydan, J, Matseoane, K, Waxman, R (2006 b). Diagnosis of comorbid psychiatric disorders in substance users assessed with the Psychiatric Research Interview for Substance and Mental Disorders for DSM-IV. American Journal of Psychiatry 163, 689–696.CrossRefGoogle ScholarPubMed
Hasin, DS, Stinson, FS, Ogburn, E, Grant, BF (2007). Prevalence, correlates, disability and comorbidity of DSM-IV alcohol abuse and dependence in the United States – results from the National Epidemiologic Survey on Alcohol and Related Conditions. Archives of General Psychiatry 64, 830–842.CrossRefGoogle ScholarPubMed
Hasin, DS, van Rossem, R, McCloud, S, Endicott, J (1997 b). Alcohol dependence and abuse diagnoses: validity in community sample heavy drinkers. Alcoholism: Clinical and Experimental Research 21, 213–219.Google ScholarPubMed
Hettema, JM, Prescott, CA, Kendler, KS (2003). The effects of anxiety, substance use and conduct disorder on risk of major depressive disorder. Psychological Medicine 33, 1423–1432.CrossRefGoogle ScholarPubMed
Kahler, CW, Strong, DR (2006). A Rasch model analysis of DSM-IV alcohol abuse and dependence items in the National Epidemiological Survey on Alcohol and Related Conditions. Alcoholism: Clinical and Experimental Research 30, 1165–1175.CrossRefGoogle ScholarPubMed
Kendler, KS, Heath, AC, Neale, MC, Kessler, RC, Eaves, LJ (1993). Alcoholism and major depression in women: a twin study of the causes of comorbidity. Archives of General Psychiatry 50, 690–698.CrossRefGoogle ScholarPubMed
Kessler, RC, Crum, RM, Warner, LA, Nelson, CB, Schulenberg, J, Anthony, JC (1997). Lifetime co-occurrence of DSM-III-R alcohol abuse and dependence with other psychiatric disorders in the National Comorbidity Survey. Archives of General Psychiatry 54, 313–321.CrossRefGoogle ScholarPubMed
Keyes, KM, Krueger, RF, Grant, BF, Hasin, DS (2010). Alcohol craving and the dimensionality of alcohol disorders. Psychological Medicine 41, 629–640.CrossRefGoogle ScholarPubMed
Kuo, PH, Gardner, CO, Kendler, KS, Prescott, CA (2006). The temporal relationship of the onsets of alcohol dependence and major depression: using a genetically informative study design. Psychological Medicine 36, 1153–1162.CrossRefGoogle ScholarPubMed
Lynskey, MT (1998). The comorbidity of alcohol dependence and affective disorders: treatment implications. Drug and Alcohol Dependence 52, 201–209.CrossRefGoogle ScholarPubMed
Marmorstein, NR, Iacono, WG, Malone, SM (2010). Longitudinal associations between depression and substance dependence from adolescence through early adulthood. Drug and Alcohol Dependence 107, 154–160.CrossRefGoogle ScholarPubMed
Martin, CS, Chung, T, Kirisci, L, Langenburcher, JW (2006). Item response theory analysis of diagnostic criteria for alcohol and cannabis use disorders in adolescents: implications for DSM-V. Journal of Abnormal Psychology 115, 807–814.CrossRefGoogle ScholarPubMed
Prescott, CA, Aggen, SH, Kendler, KS (2000). Sex-specific genetic influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins. Archives of General Psychiatry 57, 803–811.CrossRefGoogle Scholar
Pull, CB, Saunders, JB, Mavreas, V, Cottler, LB, Grant, BF, Hasin, DS, Blaine, J, Mager, D, Ustun, BT (1997). Concordance between ICD-10 alcohol and drug use disorder criteria and diagnoses as measured by the AUDADIS-ADR, CIDI and SCAN: results of a cross-national study. Drug and Alcohol Dependence 47, 207–216.CrossRefGoogle ScholarPubMed
Research Triangle Institute (2004). Software for Survey Data Analysis (SUDAAN), Version 9.0. Research Triangle Institute: Research Triangle Park, NC.Google Scholar
Rohde, P, Lewinsohn, PM, Kahkler, CW, Seeley, JR, Brown, RA (2001). Natural course of alcohol use disorders from adolescence to young adulthood. Journal of the American Academy of Child and Adolescent Psychiatry 40, 83–90.CrossRefGoogle ScholarPubMed
Ross, HE (1995). DSM-III-R alcohol abuse and dependence and psychiatric comorbidity in Ontario: results from the Mental Health Supplement to the Ontario Health Survey. Drug and Alcohol Dependence 39, 111–128.CrossRefGoogle Scholar
Saha, TD, Chou, SP, Grant, BF (2006). Toward an alcohol use disorder continuum using item response theory: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Psychological Medicine 36, 931–941.CrossRefGoogle ScholarPubMed
Shmulewitz, D, Keyes, K, Beseler, C, Aharonovic, E, Aivadyan, C, Spivak, B, Hasin, D (2010). The dimensionality of alcohol use disorders: results from Israel. Drug and Alcohol Dependence 111, 146–154.CrossRefGoogle ScholarPubMed
Swendsen, JD, Merikangas, KR (2000). The comorbidity of depression and substance use disorders. Clinical Psychological Review 20, 173–189.CrossRefGoogle ScholarPubMed
Wang, J, Patten, SB (2002). Prospective study of frequent heavy alcohol use and the risk of major depression in the Canadian general population. Depression and Anxiety 15, 42–45.CrossRefGoogle ScholarPubMed