Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-04T18:20:42.815Z Has data issue: false hasContentIssue false
  • English
  • Français

Aberrant interleukin-2 receptor-mediated blastoformation of peripheral blood lymphocytes in a severe major depressive episode

Published online by Cambridge University Press:  01 March 1998

S. KANBA ,
H. MANKI ,
F. SHINTANI ,
Y. OHNO ,
G. YAGI  and
M. ASAI
S. KANBA
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
H. MANKI
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
F. SHINTANI
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
Y. OHNO
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
G. YAGI
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
M. ASAI
Affiliation:
From the Department of Neuropsychiatry, Yamanashi Medical University, Yamanashi-ken and Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
Get access Rights & Permissions [Opens in a new window]

Abstract

Background. We examined interleukin-2 (IL-2) related immune pathways in depression to elucidate mechanisms underlying various immunological disturbances associated with depression.

Methods. Subjects comprised 35 unmedicated patients with a major depressive episode without psychotic features and 36 age- and sex-matched healthy volunteers. The immune parameters examined included the numbers of B and T cells, IL-2 receptor-mediated blastoformation (IL-2R-mediated blastoformation), IL-2 production and expression of the IL-2 receptor α-subunit.

Results. The patients with a severe episode showed significantly lower IL-2R-mediated blastoformation than the controls. There was a statistically significant negative correlation between IL-2R-mediated blastoformation and the severity of depression at the time of entry.

Conclusion. The reduced IL-2R-mediated blastoformation may partly explain several previously reported abnormal immune functions associated with depression.

Type
BRIEF COMMUNICATION
Information
Psychological Medicine , Volume 28 , Issue 2 , March 1998 , pp. 481 - 484
Copyright
© 1998 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)