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Epidémiologie de la dépression: données récentes. II — Epidémiologie analytique et épidémiologie d’évaluation

Published online by Cambridge University Press:  28 April 2020

G. Bertschy ,
S. Vandel  and
R. Volmat
G. Bertschy
Affiliation:
Service de psychiatrie, Hôpital Saint-Jacques, 2, place St-Jacques, 25030Besançon Cedex
S. Vandel
Affiliation:
Service de pharmacologie clinique, Hôpital Jean-Minjoz, boulevard Fleming, 25030Besançon Cedex, France
R. Volmat
Affiliation:
Service de psychiatrie, Hôpital Saint-Jacques, 2, place St-Jacques, 25030Besançon Cedex
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Résumé

Les données provenant d’études récentes concernant l’épidémiologie analytique et l’épidémiologie d’évauation de la dépression sont examinées.

Au sujet de l’épidémiologie analytique, il peut être conclu de la littérature actuellement disponible que les principaux facteurs de risques pour la dépression majeure sont : a) Sociodémographiques, à savoir : être une femme, être jeune, séparé, divorcé, ou avoir des problèmes conjugaux (les auteurs soulignent en particulier que les différences entre les sexes, concernant la dépression, sont réelles et ne sont pas un artefact lié à la façon de relater les troubles ou au comportement vis-à-vis des soins), b) Environnementaux: facteurs prédisposants (les événements de vie qui surviennent durant l'enfance peuvent prédisposer un individu à la dépression à l’âge adulte) et facteurs précipitants (il y a relation entre la survenue d’événements de vie pendant la vie adulte et le début de la dépression), c) Familiaux: il y a une multiblication par 2 à 5 du taux de dépression majeure chez les parents de premier degré de sujets témoins par rapport à es témoins non malades. L’influence de l’hérédité génétique est supportée par des études de jumeaux et des études adoption, mais une large part de la variance ne peut être expliquée, d) Divers: qui concernent le cycle de reproduc- 10n de la femme (la période du post partum entraîne une augmentation du taux de dépression) et les variations saisonneres (pics au printemps et en automne).

En ce qui concerne l'épidémiologie d’évaluation, il est habituel de distinguer prévention primaire, secondaire et teriaie. Leur dessein est respectivement de diminuer l’incidence de la dépression, la prévalence de la dépression et les isques de chronicité et de la récurrence. Les efforts concernant la prévention primaire ne peuvent avoir qu’un effet imité. Dans le domaine de la prévention secondaire, il peut être conclu que beaucoup de dépressifs ne sont pas diaglostiqués ou ne sont pas traités. La prévention tertiaire a pour dessein de limiter deux risques: la chronicité et la récurence. Le premier pourrait être évalué à 15-20% à chaque épisode. Les facteurs de risques principaux seraient la présence un trouble psychiatrique non affectif ou d’une affection physique, une personnalité névrotique et un faible niveau le traitement. Pour le risque de récurrence, on peut considérer qu’entre 50 et 85% des patients ayant fait un épisode lépressif majeur feront au moins un autre épisode de dépression ultérieurement. Les facteurs de risques pourraient re un Stand nombre d’épisodes antérieurs, un antécédent d’épisode maniaque ou d’hypomanie, l’association à un ésordre psychiatrique non affectif ou à une affection physique, une histoire familiale de maladie affective ou un âge e début tardif.

Summary

Summary

It can be concluded from currently available literature in analytic epidemiology that the main risk factors for depression are: a) Sociodemographical, that is to say: being female, young, divorced or having marital discord (the authors insist on the fact that sex differences in depression are real and not an artifact of reporting or health care behavior), b) Environmental: predisposing factors (events occurring in childhood may predispose a person to depression in adulthood) and precipitating factors (there is a relationship between events in adult life and the onset of depression), c) Familial: there is a 2 to 5-fold increase in major depression in first degree relatives of probands suffering from depression as compared to relatives of non ill control subjects. The influence of genetic heredity is supported by studies of twins and adoption cases, but a large part of the variance is not accounted for. d) Miscellaneous: those which concern the female reproductive system (the post partum period induces an increase in depression) and seasonal variations (peaks in spring and autumn).

Regarding epidemiology evaluation, it is customary to distinguish between primary, secondary and tertiary prevention. Their aim is respectively to diminish depression incidence, prevalence and the risk of chronicity and relapse. Efforts at primary prevention can have only limited effectiveness. In the field of secondary prevention, it can be concluded that many people suffering from depression are undiagnosed and untreated. Tertiary prevention aims at limiting two risks: chronicity and recurrence. Following a given period of depression, chronicity can be estimated at from 15-20%. Risk factors may be: presence of a non affective psychiatric disorder or a physical illness, a neurotic personality and a low level of treatment. As for the risk of recurrence, 50-85% of patients suffering from major depression will have at least one subsequent episode later in life. Risk factors may be: a great number of previous episodes, a manic or hypomanic previous episode, the presence of a non affective psychiatric disorder or a physical illness, a family history of affective illness and an older age at onset.

Keywords

dépressionépidémiologie analytiquefadeurs de risquesépidémiologie d'évaluationchronicitérécurrencedepressionanalytic epidemiologyrisk factorsevaluation epidemiologychronicityrecurrence
Type
Revue
Information
Psychiatry and Psychobiology , Volume 3 , Issue 4 , 1988 , pp. 213 - 225
Copyright
Copyright © European Psychiatric Association 1988

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References

Références

Adler, D.A.Levinson, D.J. & Astrachan, B.M. (1978) The concept of prevention in psychiatry. A reexamination. Arch. Gen. Psychiatry 35, 786–789CrossRefGoogle ScholarPubMed
Aiach, P. & Cebe, D. (1986) Diagnostic et gestion du trouble «psy» en médecine générale. Synapse 23, 34–41Google Scholar
Akiskal, H.S.Bitar, A.H.Puzantian, V.R.Rosenthal, T.L. & Walker, P.W. (1978) The nosological status of neurotic depression. A prospective three to four year follow-up examination in light of the primary–secondary and unipolar–bipolar dichotomies. Arch. Gen. Psychiatry 35, 756–766CrossRefGoogle ScholarPubMed
Akiskal, H.S. (1982) Factors associated with incomplete recovery in primary depressive illness. J. Clin. Psychiatry 43, 266–271Google ScholarPubMed
Amenson, C.S. & Lewinsohn, P.M. (1981) An investigation into the observed sex difference of unipolar depression. J. Abnorm. Psychol. 90, 1–13CrossRefGoogle ScholarPubMed
American Psychiatrie Association (1985) Consensus Development Panel. Mood disorders: pharmacologie prevention of recurrences. Am. J. Psychiatry 142, 469–476CrossRefGoogle Scholar
Amiel, R. (1986) La notion de santé mentale et son évaluation dans les études épidémiologiques à visées préventives en médecine du travail et en santé communautaire. Arch. Mal. Prof. (Paris) 47, 1–14Google Scholar
Amiel-Lebigre, F.Pelc, I. & Lagorce, A. (1984) Evénements existentiels et dépression, une étude comparative de plusieurs types de déprimés. Ann. Med. Psychol. (Paris) 142, 937–949Google Scholar
Andreasen, N.C.Rice, J. & Endicott, J. (1986) The fanrily history approach to diagnosis. How useful is it? Arch. Gen. Psychiatry 32, 421–429CrossRefGoogle Scholar
Andreasen, N.C.Rice, J.Endicott, J.Coryell, W.Grove, W.M. & Reich, T. (1987) Familial rates of affective disorder. A report from the National Institute of Mental Health collaborative study. Arch. Gen. Psychiatry 44, 461–469CrossRefGoogle ScholarPubMed
Angst, J.Felder, W. & Frey, R. (1979) The course of unipolar and bipolar affective disorders. In: Origin, Prevention and Treatment of Affective Disorders. (Schou, M. & Stromgren, E. eds.) Academic Press, London, pp. 215–226Google Scholar
Angst, J. & Dobler-Mikola, A. (1984) The Zurich study. II. The continuum from normal to pathological depressive mood swings. Eur. Arch. Psychiatr. Neurol. Sci. 234, 21–29CrossRefGoogle ScholarPubMed
Angst, J. & Dobler-Mikola, A. (1984) The Zurich study. III. Diagnosis of depression. Eur. Arch. Psychiatr. Neurol. Sci. 234, 30–37CrossRefGoogle ScholarPubMed
Angst, J. (1986) The course of affective disorders. Psycho-pathology 19 (suppl 2), 47–52CrossRefGoogle ScholarPubMed
Bebbington, P. (1987) Marital status and depression: a study of English national admission statistics. Acta Psychiatr. Scand. 75, 640–650CrossRefGoogle ScholarPubMed
Bertelsen, A.Harvard, B. & Hauge, M. (1977) A Danish twin study of manic-depressive disorders. Br. J. Psychiatry 130, 330–351CrossRefGoogle ScholarPubMed
Bifulco, A.T.Brown, G.W. & Harris, T.O. (1987) Childhood loss of parent, lack of adequate parental care and adult depression: a replication. J. Affective Disord. 12, 115–128CrossRefGoogle ScholarPubMed
Blacker, C.V.R. & Clare, A.W. (1987) Depressive disorder in primary care. Br. J. Psychiatry 150, 737–751CrossRefGoogle ScholarPubMed
Boulenger, J.P. & Zarifian, E. (1985) Les marqueurs bio-logiques périphériques en psychiatrie: intérêt des études épidémiologiques? Rev. Epidemiol. Sante Publique 33, 361–367Google Scholar
Brown, G.W.Sklair, F.Harrris, T.O. & Birley, J.L.T. (1973) Life-events and psychiatric disorders: I. Some methodological issues. Psychol. Med. 3, 74–87CrossRefGoogle ScholarPubMed
Brown, G.W. & Harris, T. (1978) Social Origins of Depression.A Study of Psychiatric Disorder in Women. Tavistock Publications, LondonGoogle Scholar
Brown, G.W.Bifulco, A. & Harris, T.O. (1987) Life events, vulnerability and onset of depression: some refinements. Br. J. Psychiatry 150, 30–42CrossRefGoogle ScholarPubMed
Burnam, M.A.Hough, R.L.Escobar, J.I.Karno, M.Timbers, D.M.Telles, C.A. & Locke, R.Z. (1987) Six-month prevalence of specific psychiatric disorders among Mexican-Americans and non hispanic whites in Los Angeles. Arch. Gen. Psychiatry 44, 687–694CrossRefGoogle ScholarPubMed
Cadoret, R.J. (1978) Evidence for genetic inheritance of primary affective disorder in adoptees. Am. J. Psychiatry 135, 463–466Google ScholarPubMed
Cadoret, R. J.O'Gorman, T.W.Heywood, E. & Troughton, E. (1985) Genetic and environmental factors in major depression. J. Affective Disord. 9, 155–164CrossRefGoogle ScholarPubMed
Cole, M.G. (1985) The course of elderly depressed outpatients. Can. J. Psychiatry 30, 217–220CrossRefGoogle Scholar
Coryell, W. & Tsuang, M.T. (1985) Major depression with mood-congruent or mood-incongruent psychotic features : outcome after 40 years. Am. J. Psychiatry 142, 479–482Google ScholarPubMed
Coryell, W.Zimmerman, M. & Pfohl, B. (1985) Short-term prognosis in primary and secondary major depression. J. Affective Disord. 9, 265–270CrossRefGoogle ScholarPubMed
Coryell, W.Andreasen, N.C.Endicott, J. & Keller, M. (1987) The significance of past mania or hypomania in the course and outcome of major depression. Am. J. Psychiatry 144, 309–315Google ScholarPubMed
Coryell, W.Endicott, J. & Keller, M. (1987) The importance of psychotic features to major depression: course and outcome during a 2-year follow-up. Acta Psychiatr. Scand. 75, 78–85CrossRefGoogle ScholarPubMed
Cremniter, D.Delcros, J.Guelfi, J.P. & Fermanian, J. (1982) Une enquête sur les états dépressifs en méde-cine générate. Encephale 8, 523–537Google Scholar
Crowell, B.A.George, L.K.Blazer, D. & Landerman, R. (1986) Psychosocial risk factors and urban/rural differences in the prevalence of major depression. Br. J. Psychiatry 149, 307–314CrossRefGoogle Scholar
Dejung, R.Rubinow, D.R.Roy-Byrne, P.Hoban, M.C.Grover, G.N. & Post, R.M. (1986) Premenstrual mood disorder and psychiatric illness. Am. J. Psychiatry 142, 1359–1361Google Scholar
Dohrenwend, B.P. & Dohrenwend, B.S. (1976) Sex differences and psychiatric disorder. Am. J. Sociology 81, 1447–1454CrossRefGoogle Scholar
Eagles, J.M. & Whalley, L.J. (1985) Ageing and affective disorders: the age at first onset of affective disorders in Scotland, 1969-1978. Br. J. Psychiatry 147, 180–187CrossRefGoogle Scholar
Eastwood, M.R. & Stiasny, S. (1978) Psychiatric disorder, hospital admission and season. Arch. Gen. Psychiatry 35, 769–771CrossRefGoogle ScholarPubMed
Egeland, J.A.Blumenthal, R.L.Nee, J.Sharpe, L. & Endicott, J. (1987) Reliability and relationship of various ages of onset criteria for major affective disorder. J. Affective. Disord. 12, 159–165CrossRefGoogle ScholarPubMed
Eisemann, M. (1985) Depressed patients and non-psychiatric controls: discriminant analysis on social environment variables. Acta Psychiatr. Scand. 71, 495–498CrossRefGoogle ScholarPubMed
Faravelli, C.Ambonetti, A.Pallanti, S. & Pazzagli, A. (1986) Depressive relapses and incomplete recovery from index episode. Am. J. Psychiatry 143, 888–891Google ScholarPubMed
Galinowski, A.Benkelfat, C. & Lajeunesse, C. (1986) Thérapies cognitives des dépressions. Acta Psychiatr. Belg. 86, 305–315Google Scholar
Gershon, E.S.Hamovit, J.Guroff, J.J.Dibble, E.Leck-man, J.F.Sceery, W.Targum, S.D.Nurnberger, J.I.Goldn, L.R. & Bunney, W.E. (1982) A family study of schizoaffective, bipolar I, bipolar II, unipolar and normal control probands. Arch. Gen Psychiatry 39, 1157–1167CrossRefGoogle ScholarPubMed
Goldberg, D. & Huxley, P. (1980) Mental Illness in the Community.The Pathway to Psychiatric Care. Tavistock Publications, LondonGoogle Scholar
Goldberg, E.L.Comstock, G.W. & Hornstra, R.K. (1979) Depressed mood and subsequent physical illness. Am. J. Psychiatry 136, 530–534Google ScholarPubMed
Haas, G.L.Glick, I.D.Spencer, J.H.Clarkin, J.F.Lewis, A.B.Good-Ellis, M.Peyser, J.De Mane, N.Harris, E. & Lestelle, V. (1986) The patient, the family and compliance with post hospital treatment for affective disorders. Psychopharmacol. Bull. 22, 999–1005Google Scholar
Halbreich, V. & Endicott, J. (1985) Relationship of dysphoric premenstrual changes to depressive disorders. Acta. Psychiatr. Scand. 71, 331–338CrossRefGoogle ScholarPubMed
Hallman, J. (1986) The premenstrual syndrome. An equivalent of depression? Acta Psychiatr. Scand. 73, 403–411CrossRefGoogle ScholarPubMed
Hallström, T. (1986) Social origins of major depression: the role of provoking agents and vulnerability factors. Acta Psychiatr. Scand. 73, 383–389CrossRefGoogle ScholarPubMed
Hirschfeld, R.M.A. & Cross, C.K. (1982) Epidemiology of affective disorders. Psychosocial risk factors. Arch. Gen. Psychiatry 39, 35–46CrossRefGoogle Scholar
Hirschfeld, R.M.A.Klerman, G.L.Andreasen, N.C.Clayton, P.J. & Keller, M.B. (1986) Psychosocial predictors of chronicity in depressed patients. Br. J. Psychiatry 148, 648–654CrossRefGoogle Scholar
Hooley, J.M.Orley, J. & Teasdale, J.D. (1986) Levels of expressed emotions and relapse in depressed patients. Br. J. Psychiatry 148, 642–647CrossRefGoogle ScholarPubMed
Hopkins, J.Marcus, M. & Campbell, S.B. (1984) Postpartum depression: a critical review. Psychol. Bull. 95, 498–515CrossRefGoogle ScholarPubMed
Hough, R.L.Lansverk, J.A.Karno, M.Burnam, M.A.Timbers, D.M.Escobar, J.I. & Regier, D.A. (1987) Utilisation of health and mental health services by Los Angeles Mexican Americans and non-hispanic whites. Arch. Gen. Psychiatry 44, 702–709CrossRefGoogle Scholar
Jablensky, A. (1987) Prediction of the course and outcome of depression. Psychol. Med. 17, 1–19CrossRefGoogle ScholarPubMed
Jakimow-Venulet, B. (1981) Hereditary factors in the pathogenesis of affective illnesses. Br. J. Psychiatry 139, 450–456CrossRefGoogle ScholarPubMed
Keller, M.B.Laudri, P.W.Endicott, J.Coryell, W. & Klerman, G.L. (1983) «Double depression»: two-year follow-up. Am. J. Psychiatry 140, 689–694Google ScholarPubMed
Keller, M.B.Lavori, P.W.Lewis, C.E. & Klerman, G.L. (1983) Predictors of relapse in major depressive disorder. J. Am. Med. Assoc. 250, 3299–3304CrossRefGoogle ScholarPubMed
Keller, M.B.Klerman, G.L.Lavori, P.W.Coryell, W.Endicott, J. & Taylor, J. (1984) Long-term outcome of episodes of major depression. J. Am. Med. Assoc. 252, 788–792CrossRefGoogle ScholarPubMed
Keller, M.B.Lavori, P.W.Klerman, G.L.Andreasen, N.C.Endicott, J.Coryell, W.Fawcett, J.Rice, J.P. & Hirschfeld, R.M.A. (1986) Low levels and lack of predictors of somatotherapy and psychotherapy received by depressed patients. Arch. Gen. Psychiatry 43, 458–466CrossRefGoogle ScholarPubMed
Keller, M.B.Lavori, P.W.Rice, J.Coryell, W. & Hirschfeld, R.M.A. (1986) The persistent risk of chronicity in recurrent episodes of nonbipolar major depressive disorder: a prospective follow-up. Am. J. Psychiatry 143, 24–28Google ScholarPubMed
Kessler, L.G.Cleary, P.D. & Burke, J.D. (1985) Psychiatric disorders in primary care. Results of a follow-up study. Arch. Gen. Psychiatry 42, 583–587CrossRefGoogle ScholarPubMed
Kettering, R.L.Harrow, M.Grossman, L. & Meltzer, H.Y. (1987) The prognostic relevance of delusions in depression: a follow-up study. Am. J. Psychiatry 144, 1154–1160Google ScholarPubMed
Kocsis, J.H.Voss, CMann, J. & Frances, A. (1986) Chronic depression: demographic and clinical characteristics. Psychopharmacol. Bull. 22, 192–195Google ScholarPubMed
Lloyd, C. (1980) Life events and depressive disorder reviewed: I. Events as predisposing factors. Arch. Gen. Psychiatry 37, 529–535CrossRefGoogle ScholarPubMed
Lloyd, C. (1980) Life events and depressive disorder reviewed: II. Events as precipitating factors. Arch. Gen. Psychiatry 37, 541–548CrossRefGoogle ScholarPubMed
Loranger, A.W. & Levine, P.M. (1978) Age at onset of bipolar affective illness. Arch. Gen. Psychiatry 35, 1345–1348CrossRefGoogle ScholarPubMed
Matussek, P.Molitor, G.A. & Seibt, G. (1985) Childhood experiences of endogenous and neurotic depressives. Eur. Arch. Psychiatr. Neurol. Sci. 235, 12–20CrossRefGoogle ScholarPubMed
Mendlewicz, J. & Rainer, J.D. (1977) Adoption study supporting genetic transmission in manic-depressive illness. Nature 268, 327–329CrossRefGoogle ScholarPubMed
Mendlewicz, J. (1985) Données génétiques actuelles sur la maniaco-dépression. Perspect. Psychiatr. 1 (100) 24–27Google Scholar
Merikangas, K.R.Bromet, E.J. & Spiker, D.G. (1983) Assortative mating, social adjustement and course of illness in primary affective disorder. Arch. Gen. Psychiatry 40, 795–800CrossRefGoogle Scholar
Merikangas, K.R.Leckman, J.F.Prusoff, D.A.Pauls, D.L. & Weissman, M.M. (1985) Familial transmission of depression and alcoholism. Arch. Gen. Psychiatry 42, 367–372CrossRefGoogle ScholarPubMed
Merikangas, K.R.Weissman, M.M. & Pauls, D.L. (1985) Genetic factors in the sex ratio of major depression. Psychol. Med. 15, 63–69CrossRefGoogle ScholarPubMed
Myers, J.K.Weissman, M.M.Tischler, G.L.Holzer, C.E.Leaf, P.J.Orvaschel, H.Antony, J.C.Boyd, J.H.Burke, J.D.Kramer, M. & Stoltzman, R. (1984) Six-month prevalence of psychiatric disorders in three communities, 1980-1982. Arch. Gen. Psychiatry 41, 959–967CrossRefGoogle Scholar
Nielsen, A.C. & Williams, T.A. (1980) Depression in ambulatory medical patients. Prevalence by self-report questionnaire and recognition by non psychiatric physicians. Arch. Gen. Psychiatry 37, 999–1004CrossRefGoogle Scholar
Nolen-Hocksema, S. (1987) Sex differences in unipolar depression: evidence and theory. Psychol. Bull. 101, 259–282CrossRefGoogle Scholar
Parker, G. (1979) Parental characteristics in relation to depressive disorders. Br. J. Psychiatry 134, 138–147CrossRefGoogle ScholarPubMed
Parker, G. & Brown, L.B. (1982) Coping behaviors that mediate between life events and depression. Arch. Gen. Psychiatry 39, 1386–1391CrossRefGoogle ScholarPubMed
Paykel, E.S.Myers, J.K.Dienelt, M.N.Klerman, G.L.Lindenthal, J.J. & Pepper, M.P. (1969) Life events and depression: a controlled study. Arch. Gen. Psychiatry 21, 753–760CrossRefGoogle ScholarPubMed
Paykel, E.S. & Tanner, J. (1976) Life events, depressive relapse and maintenance treatment. Psychol. Med. 6, 481–485CrossRefGoogle ScholarPubMed
Paykel, E.S. (1978) Contribution of life events to causation of psychiatric illness. Psychol. Med. 8, 245–253CrossRefGoogle ScholarPubMed
Paykel, E.S.Rao, B.M. & Taylor, C.N. (1984) Life stress and symptom pattern in out-patient depression. Psychol. Med. 14, 559–568CrossRefGoogle ScholarPubMed
Perris, H. (1984) Life events and depression. II. Results in diagnostics subgroups and in relation to the recurrence of depression. J. Affective Disord. 7, 25–36CrossRefGoogle Scholar
Perris, CArrindell, W.A.Perris, H.Eisemann, M.Van Der Ende, J. & Von Knorring, L. (1986) Perceived depriving parental rearing and depression. Br. J. Psychiatry 148, 170–175CrossRefGoogle ScholarPubMed
Prien, R.F. & Kupfer, D.J. (1986) Continuation drug therapy for major depressive episodes: how long should it be maintained? Am. J. Psychiatry 143, 18–23Google ScholarPubMed
Roberts, R.E. & Vernon, S.W. (1982) Depression in the community-prevalence and treatment. Arch. Gen. Psychiatry 39, 1407–1409CrossRefGoogle ScholarPubMed
Robins, L.N.Helzer, J.E.Weissman, M.M.Orvaschel, H.Gruenberg, E.Burke, J.D. & Regier, D.A. (1984) Lifetime prevalence of specific psychiatric disorders in three sites. Arch. Gen. Psychiatry 41, 949–958CrossRefGoogle ScholarPubMed
Rouillon, F. (1985) Epidémiologic des maladies mentales. Encycl. Med. Chir. (Paris), Psychiatrie 37878 A10, 10Google Scholar
Rouillon, F.Lemperiere, T.Toro, P.Waintraub, L. & Planat, P. (1987) Etude épidémiologique des états dépressifs de la grossesse et du postpartum. Rev. Fr. Psychiatr. 5 (8) 11–17Google Scholar
Roy-Byrne, P.Post, R.M.Uhde, T.W.Purcu, T. & David, D. (1985) The longitudinal course of recurrent affective illness: life chart data from research patients at the NIMH. Acta Psychiatr. Scand. 71, (suppl. 317) 34CrossRefGoogle Scholar
Rumeau-Rouquette, CBreart, G. & Padieu, R. (1981) Méthodes en Epidémiologie. Flammarion, ParisGoogle Scholar
Schou, M. (1986) New developments in long-term preventive therapy. Psychopathology 19 (2), 201–206CrossRefGoogle ScholarPubMed
Schulberg, H.C.Saul, M.McClelland, M.Ganguli, M.Christy, W. & Frank, R. (1985) Assessing depression in primary medical and psychiatric practives. Arch. Gen. Psychiatry 42, 1164–1170CrossRefGoogle Scholar
Shapiro, S.Skinner, E.A.Kessler, L.G.Von Korff, M.German, P.S.Tischler, G.L.Leaf, P.J.Benham, L.Cottier, L. & Regier, D.A. (1984) Utilization of health and mental health services. Three epidemiologic catchment area sites. Arch. Gen. Psychiatry 41, 971–978CrossRefGoogle ScholarPubMed
Smeraldi, E.Negri, F.Heimbuch, R.C. & Kidd, K.K. (1981) Familial patterns and possible modes of inheritance of primary affective disorders. J. Affective Disord. 3, 173–182CrossRefGoogle ScholarPubMed
Smeraldi, E.Macciardi, F.Holmgren, S.Perris, H.Von Knorring, L. & Perris, C. (1987) Age at onset of affective disorders in Italian and Swedish patients. Arch. Psychiatr. Scand. 75, 352–357CrossRefGoogle ScholarPubMed
Spicer, C.C.Hare, E.H. & Slater, E. (1973) Neurotic and psychotic forms of depressive illness: evidence from age-incidence in a national sample. Br. J. Psychiatry 123, 535–541CrossRefGoogle Scholar
Tennant, C. & Bebbington, P. (1978) The social causation of depression: a critique of the work of Brown and his colleagues. Psychol. Med. 8, 565–575CrossRefGoogle Scholar
Tennant, CBebbington, P. & Hurry, J. (1980) Parental death in childhood and risk of adult depressive disorders: a review. Psychol. Med. 10, 289–299CrossRefGoogle ScholarPubMed
Tennant, C. (1985) Female vulnerability to depression. Psychol. Med. 15, 733–737CrossRefGoogle ScholarPubMed
Tilley, D.H.Goldberg, S.C.Friedel, R.O. & Hamer, R.M. (1983) Therapeutic practice with tricyclic antidepres-sants among expert and general practice psychiatrists. Neuropharmacology 22, 543–548CrossRefGoogle Scholar
Torgensen, J. (1986) Genetic factors in moderately severe and mild affective disorders. Arch. Gen. Psychiatry 43, 222–226CrossRefGoogle Scholar
Von, Knorring A.L.Cloninger, R.Bohman, M. & Sig-vardsson, S. (1983) An adoption study of depressive disorders and substance abuse. Arch. Gen. Psychiatry 40, 943–950Google Scholar
Weeke, A.Bille, M.Videbech, T.H.Dupont, A.Juel-nielsen, N. (1975) Incidence of depressive syndromes in a Danish county. Acta Psychiatr. Scand. 51, 28–41CrossRefGoogle Scholar
Weissman, M.M. & Klerman, G.L. (1977) The chronic depressive in the community unrecognized and poorly treated. Compr. Psychiatry 18, 523–532CrossRefGoogle ScholarPubMed
Weissman, M.M.Prusofff, B.A. & Klerman, G.L. (1978) Personality and the prediction of long-term outcome of depression. Am. J. Psychiatry 135, 797–800Google ScholarPubMed
Weissman, M.M. (1979) The myth of involutional melancholia. J. Am. Med. Assoc. 242, 742–744CrossRefGoogle ScholarPubMed
Weissman, M.M.Myers, J.K. & Thompson, W.D. (1981) Depression and its treatment in a US urban community, 1975-1976. Arch. Gen. Psychiatry 38, 417–421CrossRefGoogle Scholar
Weissman, M.M.Kidd, K.K. & Prusoff, B.A. (1982) Variability in rates of affective disorders in relatives of depressed and normal probands. Arch. Gen. Psychiatry 39, 1397–1403CrossRefGoogle ScholarPubMed
Weissman, M.M.Gershon, E.S.Kidd, K.K.Prusoff, B.A.Leckman, J.F.Dibble, E.Hamovit, J.Thompson, D.Pauls, D.L. & Guroff, J.J. (1984) Psychiatric disorders in the relatives of probands with affective disorders. Arch. Gen. Psychiatry 41, 13–21CrossRefGoogle ScholarPubMed
Weissman, M.M.Leaf, P.J.Holzer, C.E.Myers, J.K. & Tischler, G.L. (1984) The epidemiology of depression. An update on sex differences in rate. J. Affective. Disord. 7, 179–188CrossRefGoogle Scholar
Weissman, M.M. & Klerman, G.L. (1985) Gender and depression. Trends Neurosci. 8, 416–420CrossRefGoogle Scholar
Weissman, M.M.Merikangas, K.R.Wickramaratne, P.Kidd, K.K.Prusoff, B.A.Leckman, J.F. & Pauls, D.L. (1986) Understanding the clinical heterogeneity of major depression using family data. Arch. Gen. Psychiatry 43, 430–434CrossRefGoogle ScholarPubMed
Weissman, M.M. (1987) Advances in psychiatric epidemiology: rates and risks for major depression. Am. J. Public Health 11, 445–451CrossRefGoogle Scholar
Williams, P.Balestrieri, M. & Tansella, M. (1987) Seasonal variation in affective disorders. A case register study. J. Affective Disord. 12, 145–152CrossRefGoogle ScholarPubMed
Winokur, G. (1973) Depression in the menopause. Am. J. Psychiatry 130, 92–93CrossRefGoogle ScholarPubMed
Zimmerman, M.Coryell, W. & Pfohl, B. (1986) Melancholic subtyping: a qualitative or quantitative distinction? Am. J. Psychiatry 143, 98–100Google ScholarPubMed
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