In the early morning of January 11, 2000, while
walking from home to his office at the J. Willard Gibbs
Laboratory, Paul Sigler, one of the giants in structural
biology of our time, collapsed and passed away. While 65
years old, an age when many may be resting on past successes,
Paul was in mid-course, achieving greater and greater heights
of structural and chemical understanding of basic biological
systems of transcription, signal transduction, interfacial
catalysis, and chaperonin-mediated protein folding. As a
father of five grown children, he was also savoring, with
his wife Jo, the arrival and maturation of eight grandchildren
living in the United States, England, and Israel. We extend
our deepest sympathies to his family.