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Micronutrients and host resistance to viral infection

Published online by Cambridge University Press:  28 February 2007

Melinda A. Beck  and
Colette C. Matthews
Melinda A. Beck*
Affiliation:
Departments of Pediatrics and CB #7220, University of NC at Chapel Hill, Chapel Hill, NC 27599–7220, USA Nutrition, CB #7220, University of NC at Chapel Hill, Chapel Hill, NC 27599–7220, USA
Colette C. Matthews
Affiliation:
Nutrition, CB #7220, University of NC at Chapel Hill, Chapel Hill, NC 27599–7220, USA
*
*Corresponding author: Professor Melinda Beck, fax +1 919 966 0135, email [email protected]
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Abstract

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Previous work in our laboratory demonstrated that a virus could undergo rapid mutation in a host deficient in Se, leading to a normally avirulent virus acquiring virulence due to genome changes. Once these mutations occur, even a host with adequate Se-nutriture is susceptible to the newly virulent virus. What influence does the deficiency in Se have on the immune response of the host? Infection with myocarditic strains of coxsackievirus induces an inflammatory response in the cardiac tissue. It is this immune response that induces the heart damage, rather than direct viral effects on the heart tissue. Chemokines are chemo-attractant molecules that are secreted during an infection in order to attract immune cells to the site of the injury, and have been found to be important for the development of coxsackievirus-induced myocarditis. We found that a deficiency in Se influences the expression of mRNA for the chemokine monocyte chemo-attractant protein-1, which may have implications for the development of myocarditis in the Se-deficient host. Expression of mRNA for interferon-γ was also greatly decreased in the Se-deficient animal. Thus, a deficiency in Se can have profound effects on the host as well as on the virus itself. How the alteration of the immune response of the Se-deficient animal affects the development of the virulent genotype remains to be answered.

Keywords

SeleniumCoxsackievirus-induced myocarditisImmune responseChemokines
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 59 , Issue 4 , November 2000 , pp. 581 - 585
Copyright
Copyright © The Nutrition Society 2000

References

Beck, MA, Kolbeck, PC, Rohr, LH, Shi, Q, Morris, VC & Levander, OA (1994) Amyocarditic coxsackievirus becomes myocarditic in selenium deficient mice. Journal of Medical Virology 43, 166–170.CrossRefGoogle Scholar
Beck, MA, Shi, Q, Morris, VC & Levander, OA (1995) Rapid genomic evolution of a non-virulent Coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates. Nature Medicine 1, 433–436.CrossRefGoogle ScholarPubMed
Bendich, A & Chandra, RK (1990) Micronutrients and immune functions. Annals of the New York Academy of Sciences 587, 168–180.CrossRefGoogle Scholar
Cook, DN, Beck, MA, Coffman, T, Kirby, SL, Sheridan, JF, Pragnell, IB & Smithies, O (1995) Requirement of MIP-1α for inflammatory response to viral infection. Science 269, 1583–1585.CrossRefGoogle Scholar
Good, RA & Lorenz, E (1992) Nutrition and cellular immunity. International Journal of Immunopharmacology 14, 361–366.Google Scholar
Gu, BQ (1983) Pathology of Keshan disease. A comprehensive review. Chinese Medical Journal 96, 251–261.Google Scholar
Keshan Disease Research Group of the Chinese Academy of Medical Sciences (1979) Observations on effect of sodium selenite in prevention of Keshan disease. Chinese Medical Journal 92, 471–476.Google Scholar
Leslie, K (1989) Clinical and experimental aspects of viral myocarditis. Clinical Microbiology Reviews 2, 191–197.Google Scholar
Li, Y, Yang, Y & Chen, H (1995) Detection of enteroviral RNA in paraffin-embedded myocardial tissue from patients with Keshan disease by nested PCR. Chung Hua I Hsueh Tsa Chih 75, 344–345.Google Scholar
Nelson, HK, Van Dael, P, Schiffrin, EJ, Brussow, H, Blum, S, Barclay, D & Beck, MA (2000) Selenium deficiency enhances the pathogenicity of influenza virus infection. FASEB Journal 14, A536.Google Scholar
O'Connell, J & Robinson, J (1985) Coxsackie viral myocarditis. Postgraduate Medical Journal 61, 1127–1131.Google Scholar
Reffett, JK, Spears, JW & Brown, TT Jr (1988 a) Effect of dietary selenium and vitamin E on the primary and secondary immune response in lambs challenged with parainfluenza 3 virus. Journal of Animal Sciences 66, 1520–1528.CrossRefGoogle Scholar
Reffett, JK, Spears, JW & Brown, TT Jr (1988 b) Effect of dietary selenium on the primary and secondary immune response in calves challenged with infectious bovine rhinotracheitis. Journal of Nutrition 118, 229–235.CrossRefGoogle ScholarPubMed
Scrimshaw, NS (1975) Nutrition and infection. Progress in Food and Nutrition Science 1, 393–420.Google ScholarPubMed
Scrimshaw, NS, Taylor, CE & Gordon, JE (1968) Interactions of Nutrition and Infection. WHO Monograph Series no. 57, Geneva: WHO.Google Scholar
Su, C, Gong, C, Li, J, Chen, L, Zhou, D & Jin, Q (1979) Preliminary results of viral etiology of Keshan disease. Chinese Medical Journal 59, 466–472.Google Scholar
Woodruff, JF (1980) Viral myocarditis. A review. American Journal of Pathology 101, 427–482.Google ScholarPubMed
Woodruff, JF & Woodruff, JJ (1974) Involvement of T lymphocytes in the pathogenesis of coxsackie virus B3 heart disease. Journal of Immunology 113, 17–26.Google ScholarPubMed
Zlotnik, A & Yoshie, O (2000) Chemokines: A new classification system and their role in immunity. Immunity 12, 121–127.Google Scholar