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β-Carotene and the Immune Response

Published online by Cambridge University Press:  28 February 2007

Adrianne Bendich
Adrianne Bendich
Affiliation:
Hoffman-La Roche Inc., Nutley, NJ 07110, USA
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Abstract

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Type
Symposium on ‘Micronutrients and the immune response’
Information
Proceedings of the Nutrition Society , Volume 50 , Issue 2 , August 1991 , pp. 263 - 274
Copyright
The Nutrition Society

References

Abril, E. R., Rybski, J. A., Scuderi, P. & Watson, R. R. (1989). Beta carotene stimulates human leukocytes to secrete novel cytokine. Journal of Leukocyte Biology 45, 255–261.CrossRefGoogle ScholarPubMed
Alexander, M., Newmark, H. & Miller, R. G. (1985). Oral beta-carotene can increase the number of OKT4+ cells in human blood. Immunology Letters 9, 221–224.CrossRefGoogle ScholarPubMed
Belisario, M. A., Pecce, R., Battista, C., Panza, N. & Pacillo, G. (1985). Inhibition of cyclophosphamide mutagenicity by beta-carotene. Biomedicine and Pharmacotherapy 39, 445–448.Google ScholarPubMed
Bendich, A. (1988). A role for carotenoids in immune function. Clinical Nutrition 7, 113–117.Google Scholar
Bendich, A. (1989). Carotenoids and the immune response. Journal of Nutrition 119, 112–115.CrossRefGoogle ScholarPubMed
Bendich, A. (1990). Carotenoids and the immune system. In Carotenoids: Chemistry and Biology, pp. 323–336 [Krinsky, N. I., Mathews-Roth, M. M. and Taylor, R. F., editors]. New York: Plenum Press.Google Scholar
Bendich, A. & Olson, J. A. (1989). Biological actions of carotenoids. FASEB Journal 3, 1927–1932.CrossRefGoogle ScholarPubMed
Bendich, A. & Shapiro, S. S. (1986). Effect of beta-carotene and canthaxanthin on the immune responses of the rat. Journal of Nutrition 116, 2254–2262.CrossRefGoogle ScholarPubMed
Clausen, S. W. (1931). Carotenemia and resistance to infection. Transactions of American Pediatric Society 43, 27–30.Google Scholar
Forssberg, A., Lingen, C., Ernster, L. & Lindberg, O. (1959). Modification of the X-irradiation syndrome by lycopene. Experimental Cell Research 16, 7–14.CrossRefGoogle ScholarPubMed
Garewal, H. S. & Shamdas, G. J. (1991). Intervention trials with beta-caroten in precancerous conditions of the upper aerodigestive tract. In Preventive Nutrition, pp. 127–140 [Bendich, A. and Butterworth, C. E., editors]. New York: Marcel Dekker, Inc.Google Scholar
Gensler, H. L. (1989). Reduction of immunosuppression in UV-irradiated mice by dietary retinyl palmitate plus canthaxanthin. Carcinogenesis 10, 203–207.CrossRefGoogle ScholarPubMed
Green, H. N. & Mellanby, E. (1930). Carotene and vitamin A: the anti-infective action of carotene. British Journal of Experimental Pathology 11, 81–89.Google Scholar
Greenwald, E. D. & Greenwald, E. S. (1983). Skin cancer. In Cancer Epidemiology, pp. 26–29. New York: Medical Examination Publishing Co., Inc.Google Scholar
Gruner, S., Volk, H., Falck, P. & Von Baehr, R. (1986). The influence of phagocytic stimuli on the expression of HLA-DR antigens; role of reactive oxygen intermediates. European Journal of Immunology 6, 212–215.CrossRefGoogle Scholar
Halevy, O. & Sklan, D. (1987). Inhibition of arachidonic acid oxidation by beta-carotene, retinol and α-tocopherol. Biochimica Biophysica Acta 918, 304–307.CrossRefGoogle ScholarPubMed
Hazuka, M. B., Edwards-Prasad, J., Newman, F., Kinzie, J. J. & Prasad, K. N. (1990). Beta carotene induces morphological differentiation and decreases adenylate activity in melanoma cells in culture. Journal – American College of Nutrition 9, 143–149.CrossRefGoogle ScholarPubMed
He, Y. & Campbell, T. C. C. (1990). Effects of carotenoids on aflatoxin B1-induced mutagenesis in S. typhimurium TA 100 and TA 98. Nutrition and Cancer 13, 243–253.CrossRefGoogle Scholar
Kim, T. -Y.., Kripke, M. L. & Ullrich, S. E. (1990). Immunosuppression by factors released from UV-irradiated epidermal cells: Selective effects on the generation of contact and delayed hypersensitivity after exposure to UVA or UVB radiation. Journal of Investigative Dermatology 94, 26–32.CrossRefGoogle ScholarPubMed
Krinsky, N. I. (1989). Beta carotene: functions. In New Protective Roles for Selected Nutrients, pp. 1–15 [Spiller, G. A. and Scala, J., editors]. New York: Alan R. Liss, Inc.Google Scholar
Leslie, C. A. & Dubey, D. P. (1982). Carotene and natural killer cell activity. Federation Proceedings 41, 331.Google Scholar
Lingen, C. (1958). On the Promoting Effect of Lycopene and Related Substances on the Non-specific Resistance of Animals. Stockholm: Karolinska Institute.Google Scholar
Lingen, C., Ernster, L. & Lindberg, O. (1959). The promoting effect of lycopene on the non-specific resistance of animals. Experimental Cell Research 16, 384–393.CrossRefGoogle ScholarPubMed
Malter, M., Schriever, G. & Eilber, U. (1989). Natural killer cells, vitamins, and other blood components of vegetarian and omnivorous men. Nutrition and Cancer 12, 271–278.CrossRefGoogle ScholarPubMed
Mathews-Roth, M. M. (1989). Beta-carotene: Clinical Aspects. In New Protective Roles for Selected Nutrients, pp. 17–38 [Spiller, G. A. and Scala, J., editors]. New York: Alan R. Liss, Inc.Google Scholar
Moore, T. (1930). Vitamin A and carotene. VI. The conversion of beta carotene to vitamin A in vivo. Biochemical Journal 24, 692–702.CrossRefGoogle Scholar
Pelham, H. R. B. (1986). Speculations on the functions of the major heat shock and glucose regulated proteins. Cell 46, 959–961.CrossRefGoogle ScholarPubMed
Prabhala, R. H., Maxey, V., Hicks, M. J. & Watson, R. R. (1989). Enhancement of the expression of activation markers on human peripheral blood mononuclear cells by in vitro culture with retinoids and carotenoids. Journal of Leukocyte Biology 45, 249–254.CrossRefGoogle ScholarPubMed
Pung, A., Rundhaug, J. E., Yoshizawa, C. N. & Bertram, J. S. (1988). Beta-carotene and canthaxanthin inhibit chemically- and physically-induced neoplastic transformation in 10T1/2 cells. Carcinogenesis 9, 1533–1539.CrossRefGoogle Scholar
Raj, A. S. & Katz, M. (1985). Beta-carotene as an inhibitor of benzo(a) pyrene and mitomycin C induced chromosomal breaks in the bone marrow of mice. Canadian Journal of Genetic Cytology 27, 598–602.CrossRefGoogle ScholarPubMed
Renner, H. W. (1985). Anticlastogenic effect of beta-carotene in Chinese hamsters: time and dose response studies with different mutagens. Mutation Research 144, 251–256.Google ScholarPubMed
Rhodes, J. (1983). Human interferon action: reciprocal regulation by retinoic acid and beta-carotene. Journal — National Cancer Institute 70, 833–837.Google ScholarPubMed
Rhodes, J., Stokes, P. & Abrams, P. (1984). Human tumour-induced inhibition of interferon action in vitro: Reversal of inhibition by beta-carotene (pro-vitamin A). Cancer Immunology and Immunotherapy 16, 189–192.CrossRefGoogle ScholarPubMed
Schwartz, J. L. & Shklar, G. (1989). A cyanobacteria extract and beta carotene stimulate an antitumor host response against an oral cancer cell. Phytotherapy Research 3, 243–248.CrossRefGoogle Scholar
Schwartz, J. L., Shklar, G. & Flynn, E. (1990 a). The effect of carotenoids on the antitumor immune response in vivo and in vitro with hamster and mouse immune effectors. In Micronutrients and Immune Functions, pp. 92–109 [Bendich, A. and Chandra, R. K., editors]. New York: New York Academy of Sciences.Google Scholar
Schwartz, J. L., Shklar, G., Flynn, E. & Trickler, D. (1990 b). The administration of beta carotene to prevent and regress oral carcinoma in the hamster cheek pouch and the associated enhancement of the immune response. In Antioxidant Nutrients and Immune Functions, pp. 77–93 [Bendich, A., Phillips, M. and Tengerdy, R. P., editors]. New York: Plenum Press.CrossRefGoogle Scholar
Shklar, G. & Schwartz, J. L. (1988). Tumor necrosis factor in experimental cancer regression with alpha-tocopherol, beta carotene, canthaxanthin and algae extract. European Journal of Cancer and Clinincal Oncology 24, 839–850.CrossRefGoogle Scholar
Stich, H. F., Hornby, A. P. & Dunn, B. P. (1985). A pilot beta-carotene intervention trial with Inuits using smokeless tobacco. International Journal of Cancer 36, 321–327.CrossRefGoogle ScholarPubMed
Stich, H. F., Stich, W., Rosin, M. P. & Vallejera, M. O. (1984). Use of the micronucleus test to monitor the effect of vitamin A, β-carotene and canthaxanthin on the buccal mucosa of beta1 nut/tobacco chewers. International Journal of Cancer 34, 745–750.CrossRefGoogle Scholar
Tomita, Y., Fukuda, K., Engelman, R. W., Day, N. K. & Good, R. A. (1990). Effects of carotenoids on autoimmune diseases in mice. International Symposium on Carotenoids (held in Kyoto, Japan).Google Scholar
Tomita, Y., Himeno, K., Nomoto, K., Endo, H. & Hirohata, T. (1987 a). Augmentation of tumor immunity against synergic tumors in mice by beta-carotene. Journal — National Cancer Institute 78, 679–680.Google Scholar
Tomita, Y., Himeno, K., Nomoto, K., Fukuda, K. & Hirohata, T. (1987 b). Augmentation of tumor immunity in mice by carotenoids. Abstr. P 63 The 8th International Symposium on Carotenoids (held in Boston, Massachusetts).Google Scholar
Watson, R. R., Prabhala, P. H., Plezia, P. M. & Alberts, D. S. (1991). Effect of beta-carotene on lymphocyte subpopulation in elderly humans: Evidence for a dose response relationship. American Journal of Clinical Nutrition 53, 90–94.CrossRefGoogle ScholarPubMed
White, W. S., Kim, C., Kalkwarf, H. J., Bustos, P. & Roe, D. A. (1988). Ultraviolet light-induced reductions in plasma carotenoid levels. American Journal of Clinical Nutrition 47, 879–883.CrossRefGoogle ScholarPubMed