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The biochemical basis of the health effects of exercise: an integrative view

Published online by Cambridge University Press:  05 March 2007

Frank W. Booth  and
R. Andrew Shanely
Frank W. Booth*
Affiliation:
Department of Biomedical Sciences, and Physiology and the Dalton Cardiovascular Institute, University of Missouri, Columbia, Missouri, 65211, USA Department of Medical Pharmacology and Physiology and the Dalton Cardiovascular Institute, University of Missouri, Columbia, Missouri, 65211, USA
R. Andrew Shanely
Affiliation:
Department of Biomedical Sciences, and Physiology and the Dalton Cardiovascular Institute, University of Missouri, Columbia, Missouri, 65211, USA
*
*Corresponding author: Dr F.W. Booth, Fax: +1 513 884 6890, Email: [email protected]
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Abstract

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Physical inactivity–gene interactions result in changes in gene expression, leading to phenotypic changes in the skeletal muscle cell. A subpopulation of those genes that show changes in expression during physical inactivity are candidates for the environment–gene interactions that cross a threshold of biological significance such that overt clinical disease occurs. AMP kinase, GLUT4 and myosin heavy chain IIx are proposed as candidates for physical inactivity-modulated genes that have an altered function that may trigger a crossing of a threshold to disease. Future experiments will be needed to test the validity of the ideas presented.

Keywords

Gene–environment interactionPhysical activity levelsSedentary lifestyle
Type
opening lecture
Information
Proceedings of the Nutrition Society , Volume 63 , Issue 2 , May 2004 , pp. 199 - 203
Copyright
Copyright © The Nutrition Society 2004

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