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X-ray powder diffraction analysis of imipenem monohydrate

Published online by Cambridge University Press:  03 April 2012

F. Needham ,
C. E. Crowder ,
J. W. Reid ,
T. G. Fawcett  and
J. Faber
F. Needham*
Affiliation:
International Centre for Diffraction Data, 12 Campus Boulevard, Pennsylvania 19073
C. E. Crowder
Affiliation:
International Centre for Diffraction Data, 12 Campus Boulevard, Pennsylvania 19073
J. W. Reid
Affiliation:
International Centre for Diffraction Data, 12 Campus Boulevard, Pennsylvania 19073
T. G. Fawcett
Affiliation:
International Centre for Diffraction Data, 12 Campus Boulevard, Pennsylvania 19073
J. Faber
Affiliation:
International Centre for Diffraction Data, 12 Campus Boulevard, Pennsylvania 19073
*
a)Author to whom correspondence should be addressed. Electronic mail: [email protected]
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Abstract

An experimental X-ray powder diffraction pattern was produced and analyzed for imipenem monohydrate, an antimicrobial pharmaceutical agent. Although there are no experimental powder patterns in the ICDD PDF-4/Organics Database, there is one powder pattern calculated with single-crystal X-ray diffraction data from the Cambridge Structural Database. Here, we report the refined experimental powder diffraction data for imipenem monohydrate. These data for imipenem monohydrate are consistent with an orthorhombic crystal system having reduced unit-cell parameters of a = 8.2534(3) Å, b = 11.1293(4) Å, and c = 15.4609(6) Å. The resulting unit-cell volume, 1420.15(15) Å3, indicates four formula units per unit cell. Observed peaks are consistent with the P212121 space group.

Keywords

imipenemC12H17N3O4SX-ray powder diffractionβ-lactamhydrogen bonding
Type
Technical Articles
Information
Powder Diffraction , Volume 27 , Issue 1 , March 2012 , pp. 20 - 24
Copyright
Copyright © International Centre for Diffraction Data 2012

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References

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