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Strongyloides ratti: the effect of betamethasone on the course of infection in rats

Published online by Cambridge University Press:  06 April 2009

R. Moqbel  and
D. A. Denham
R. Moqbel
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
D. A. Denham
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT
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Summary

Rats were treated with betamethasone at different stages of infection with Strongyloides ratti. Treatment caused a diminution in the number of adult worms recovered but this residual population was not expelled as were worms from untreated rats. If treatment was started after expulsion had already begun adult worm numbers increased – suggesting that auto-infection occurred. Treatment throughout a primary infection prevented the development of an immune response which expelled, or killed, a challenge infection. Treatment, just before and just after challenge, prevented the expulsion of the challenge infection. Worm expulsion up to day 35 was prevented by treating rats with betamethasone 4, 6, 8 and 10 days after infection.

Type
Research Article
Information
Parasitology , Volume 76 , Issue 3 , June 1978 , pp. 289 - 298
Copyright
Copyright © Cambridge University Press 1978

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