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The inhibition by p-aminobenzoic acid of the development of paludrine-resistance as produced by sulphonamides in plasmodium gallinaceum

Published online by Cambridge University Press:  06 April 2009

Ann Bishop  and
Elspeth W. McConnachie
Ann Bishop
Affiliation:
Molteno Institute, University of Cambridge
Elspeth W. McConnachie
Affiliation:
Molteno Institute, University of Cambridge
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Extract

A strain of Plasmodium gallinaceum has been treated for 10 weeks with sulphadiazine (5 mg./20 g.) in the presence of p-aminobenzoic acid in doses (0·5 mg./ 20 g.) inhibiting the sulphadiazine. No resistance to paludrine or to sulphadiazine has developed.

Type
Research Article
Information
Parasitology , Volume 41 , Issue 1-2 , July 1951 , pp. 105 - 109
Copyright
Copyright © Cambridge University Press 1951

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References

REFERENCES

Bishop, A. & Birkett, B. (1947). Acquired resistance to paludrine in Plasmodium gallinaceum. Acquired resistance and persistence after passage through the mosquito. Nature, Lond., 159, 884.CrossRefGoogle Scholar
Bishop, A. & Birkett, B. (1948). Drug-resistance in Plasmodium gallinaceum, and the persistence of paludrine-resistance after mosquito transmission. Parasitology, 39, 125.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1948). Resistance to sulphadiazine and ‘paludrine’ in the malaria parasite of the fowl (P. gallinaceum). Nature, Lond., 162, 541.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1949 a). Sulphadiazine-resistance in Plasmodium gallinaceum and its relation to other anti-malarial compounds. Parasitology, 40, 163.CrossRefGoogle Scholar
Bishop, A. & McConnachie, E. W. (1949 b). Cross-resistance between sulphanilamide and paludrine (proguanil) in a strain of Plasmodium gallinaceum resistant to sulphanilamide. Parasitology, 40, 175.CrossRefGoogle Scholar
Greenberg, J. (1949 a). Inhibition of the antimalarial activity of chlorguanide by pteroylglutamic acid. Proc. Soc. Exp. Biol., N.Y., 71, 306.CrossRefGoogle ScholarPubMed
Greenberg, J. (1949 b). The potentiation of the antimalarial activity of chlorguanide by p-aminobenzoic acid competitors. J. Pharmacol. 97, 238.Google ScholarPubMed
Greenberg, J., Boyd, B. L. & Josephson, E. S. (1948). Synergistic effect of chlorguanide and sulfadiazine against Plasmodium gallinaceum in the chick. J. Pharmacol. 94, 60.Google ScholarPubMed
Knoppers, A. T. (1947). Acquired resistance (twofold) to quinine in Plasmodium gallinaceum. Nature, Lond., 160, 606.CrossRefGoogle ScholarPubMed
Maier, J. & Riley, E. (1942). Inhibition of antimalarial action of sulfonamides by p−aminobenzoic acid. Proc. Soc. Exp. Biol., N.Y., 50, 152.CrossRefGoogle Scholar
Marshall, E. K., Litchfield, J. T. & White, H. J. (1942). Sulfonamide therapy of malaria in ducks. J. Pharmacol. 75, 89.Google Scholar
Schmidt, L. H., Genther, C. L., Fradkin, R. & Squires, W. (1949). Development of resistance to chlorguanide (paludrine) during treatment of infections with Plasmodium cynomolgi. J. Pharmacol. 95, 382.Google ScholarPubMed
Williamson, J. & Lourie, E. M. (1947). Acquired paludrine-resistance in Palsmodium gallinaceum. I. Development of resistance to paludrine and failure to develop resistance to certain other antimalarials. Ann. Trap. Med. Parasit. 41, 278.CrossRefGoogle Scholar
Williamson, J., Bertram, D. S. &Lourie, E.M. (1947). Acquired resistance to paludrine in Plasmodium gallinaceum. Effects of paludrine and other antimalarials. Nature, Lond., 159, 885.CrossRefGoogle Scholar