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Along a TNF-paved road from dead parasites in red cells to cerebral malaria, and beyond

Published online by Cambridge University Press:  19 May 2009

I. A. CLARK
I. A. CLARK*
Affiliation:
School of Biochemistry and Molecular Biology, Australian National University, Canberra, ACT 0200, Australia
*
*Fax: +61 2 6125 0313. E-mail: [email protected]
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Summary

This is a personal account of how tumour necrosis factor (TNF) the prototype of a group of host-origin mediators, often known as pro-inflammatory cytokines, came into parasitology, and was subsequently realised to be central to the pathogenesis of most disease pathology. This contribution summarizes an example of how a curiosity-driven outsider, with initially no intention of heading this way, and no relevant experience, and with no more than the simplest of plans but an ambition to read as widely as it takes, and (most importantly) allowed to follow his head, can be what is required to give fresh insight into understanding a disease. It also gives the author's views on aspects of how the field of malaria disease pathogenesis seems to be developing. The hope is to inspire another generation to follow a similarly original course.

Keywords

TNFmalariavaccinediseasebabesiamitochondria
Type
Research Article
Information
Parasitology , Volume 136 , Special Issue 12: Special Centenary Issue – Parasitology 1908–2008 , October 2009 , pp. 1457 - 1468
Copyright
Copyright © Cambridge University Press 2009

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