Hostname: page-component-586b7cd67f-gb8f7 Total loading time: 0 Render date: 2024-11-30T20:10:14.520Z Has data issue: false hasContentIssue false
  • English
  • Français

Some general characteristics of the transport of nutrients and toxic compounds in yeasts and fungi

Published online by Cambridge University Press:  23 August 2011

A. A. Eddy
A. A. Eddy
Affiliation:
Department of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology, P.O. Box 88, Manchester M60 1QD
Get access Rights & Permissions [Opens in a new window]

Extract

This essay deals in turn with the six main mechanisms that are believed to be involved in the passage of small molecules across the cell membrane of yeasts and fungi. Such solutes include amino acids, carbohydrates, purines and pyrimidines and other nutrients, among which are the ions K+, , or . The subject has been reviewed extensively (see, for example, Eddy, 1982; Cooper, 1982; Serrano, 1984; Harold, 1986). Transport systems relate to chemotherapy in two ways. First, they may themselves be potential targets for drug action. Second, they may deliver a drug to its intracellular target, the drug being an illicit passenger in a transport system with a different primary role. Most of our knowledge about yeast and fungal transport is currently based on studies with relatively few species selected because they are known to be amenable to genetic and biochemical analysis. The organisms include representative strains of Neurospora crassa or of Saccharomyces cerevisiae and selected species of Rhodotorula and Schizosaccharomyces. Fungal organisms pathogenic to man, such as Candida albicans, those causing either systemic fungal infections (see Kerridge, 1986; Shepherd, Poulter & Sullivan, 1985), or the numerous fungal diseases of plants have been little used as models of nutrient transport, despite their clinical or economic importance. Whether all these ecologically diverse organisms, which in evolutionary terms are only distantly related, employ only the transport mechanisms so far discovered in Saccharomyces cerevisiae is an open question.

Type
Research Article
Information
Parasitology , Volume 96 , supplement S1: Symposia of the British Society for Parasitology Volume 25 Molecular transfer across parasite membranes , January 1988 , pp. S45 - S56
Copyright
Copyright © Cambridge University Press 1988

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Ahmad, M. & Bussey, H. (1986). Yeast arginine permease: nucleotide sequence of the CANI gene. Current Genetics 10, 587–92.CrossRefGoogle Scholar
Alper, M. D. & Ames, B. N. (1978). Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: Positive selection of Salmonella typhimurium cya and crp mutants. Journal of Bacteriology 133, 149–57.CrossRefGoogle ScholarPubMed
Ames, G. F.-L. (1986). The basis of multidrug resistance in mammalian cells: Homology with bacterial transport. Cell 47, 323–4.CrossRefGoogle Scholar
Boge, G. & Rigal, A. (1981). A chloride requirement for Na+-dependent amino-acid transport by brush border membrane vesicles isolated from the intestine of a mediterranean teleost (Boops Salpa). Biochimica et Biophysica Acta 649, 455–61.Google Scholar
Bowman, B. J. & Bowman, E. J. (1986). H+ATPases from mitochondria, plasma membranes, and vacuoles of fungal cells. Journal of Membrane Biology 94, 83–97.CrossRefGoogle ScholarPubMed
Cassio, F., Leao, C. & Van Uden, N. (1987). Transport of lactate and other short-chain mono-carboxylates in the yeast Saccharomyces cerevisiae. Applied and Environmental Microbiology 53, 509–13.CrossRefGoogle Scholar
Cooper, T. G. (1982). Transport in Saccharomyces cerevisiae. In The Molecular Biology of the Yeast Saccharomyces, Metabolism and Gene Expression (ed. Strathern, J. N.Jones, E. W. and Broach, J. R.), pp. 399–461. Cold Spring Harbor, New York, Cold Spring Harbor Laboratory.Google Scholar
Davey, J., Hurtley, S. M. & Warren, G. (1985). Reconstitution of an endocytic fusion event in a cell-free system. Cell 43, 643–52.Google Scholar
De Waard, M. & Van Nistelrooy, J. G. M. (1987). Inhibitors of energy-dependent efflux of the fungicide fenarimol by Aspergillus nidulans 11, 1–10.Google Scholar
Eddy, A. A. (1982). Mechanisms of solute transport in selected eukaryotic microorganisms. Advances in Microbial Physiology 23, 1–78.CrossRefGoogle Scholar
Eddy, A. A. & Hopkins, P. G. (1985). The putative electrogenic nitrate-proton symport of the yeast Candida utilis. Comparison with the systems absorbing glucose or lactate. The Biochemical Journal 231, 291–7.Google Scholar
Gustin, M. C., Martinac, B., Saimi, Y., Culbertson, M. R. & Kung, C. (1986). Ion channels in yeast. Science 233, 1195–7.Google Scholar
Harold, F. M. (1986). The Vital Force: a Study of Bioenergetics. New York: W. H. Freeman.Google Scholar
Hilpert, W., Schink, B. & Dimroth, P. (1984). Life by a new decarboxylation-dependent energy conservation mechanism with Na+ as coupling ion. The EMBO Journal 3, 1665–70.Google Scholar
Island, M. D., Naider, F. & Becker, J. M. (1987). Regulation of dipeptide transport in Saccharomyces cerevisiae by micromolar amino acid concentrations. Journal of Bacteriology 169, 2132–6.Google Scholar
Johnston, P. A. & Coddington, A. (1983). Multiple drug resistance in the fission yeast Schizosaccharomyces pombe: Correlation between drug and amino acid uptake and membrane ATPase activities. Current Genetics 7, 299–307.Google Scholar
Kinraide, T. B., Newman, I. A. & Etherton, B. (1984). A quantitative simulation model for H+-amino acid cotransport to interpret the effects of amino acids on membrane potential and extracellular pH. Plant Physiology 76, 806–13.Google Scholar
Kerridge, D. (1986). Mode of action of clinically important antifungal drugs. Advances in Microbial Physiology 27, 1–72.Google Scholar
Makarow, M. (1985). Endocytosis in Saccharomyces cerevisiae: internalization of α-amylase and fluorescent dextran into cells. The EMBO Journal 4, 1861–6.Google Scholar
Mellman, I., Fuchs, R. & Helenius, A. (1986). Acidification of the endocytic and exocytic pathways. Annual Reviews of Biochemistry 55, 663–700.Google Scholar
Mobley, H. L. T. & Rosen, B. P. (1982). Proceedings of the National Academy Sciences, USA 79, 6119–22.Google Scholar
Nikawa, J.-I., Tsukagoshi, Y. & Yamashita, S. (1986). Cloning of a gene encoding choline transport in Saccharomyces cerevisiae. Journal of Bacteriology 166, 328–30.Google Scholar
Nisbet, T. M. & Payne, J. W. (1979). Specificity of peptide uptake in Saccharomyces cerevisiae, and isolation of a bacilysin-resistant, peptide-transport-deficient mutant. FEMS Microbiology Letters 6, 193–6.CrossRefGoogle Scholar
Ongjoco, R., Szkutnicka, K. & Cirillo, V. P. (1987). Glucose transport in vesicles reconstituted from Saccharomyces cerevisiae membranes and liposomes. Journal of Bacteriology 169, 2926–31.CrossRefGoogle ScholarPubMed
Opekarova, M., Driessen, A. J. M. & Konings, W. N. (1987). Protonmotive-force-driven leucine uptake in yeast plasma membrane vesicles. Federation of European Biochemical Societies 1, 45–8.CrossRefGoogle Scholar
Sanders, D., Slayman, C. L. & Pall, M. L. (1983). Stoichiometry of H+/amino acid cotransport in Neurospora crassa revealed by current–voltage analysis. Biochimica et Biophysica Acta 735, 67–76.Google Scholar
Seaston, A., Inkson, C. & Eddy, A. A. (1973). The absorption of protons with specific amino acids and carbohydrates by yeast. The Biochemical Journal 134, 1031–43.Google Scholar
Serrano, R. (1984). Plasma membrane ATPase of fungi and plants as a novel type of proton pump. Current Topics in Cellular Regulation 23, 87–126.CrossRefGoogle ScholarPubMed
Serrano, R., Montesinos, C. & Cid, A. (1986). A temperature-sensitive mutant of the yeast plasma membrane ATPase obtained by in vitro mutagenesis. Federation of European Biochemical Societies 208, 143–6.Google Scholar
Shepherd, M. G., Poulter, R. T. M. & Sullivan, P. A. (1985). Candida albicans: Biology, genetics, and pathogenicity. Annual Reviews of Microbiology 35, 579–614.Google Scholar
Tsuchiya, T. & Shinoda, S. (1985). Respiration-driven Na+ pump and Na+ circulation in Vibrio parahaemolyticus. Journal of Bacteriology 162, 794–8.Google Scholar
Vandenbol, M., Jauniaux, J.-C., Vissers, S. & Grenson, M. (1987). Isolation of the NPR1 gene responsible for the reactivation of ammonia-sensitive amino-acid permeases in Saccharomyces cerevisiae. RNA analysis and gene dosage effects. European Journal of Biochemistry 164, 607–12.Google Scholar
Warth, A. D. (1977). Mechanism of resistance of Saccharomyces bailii to benzoic, sorbic and other weak acids used as food preservatives. Journal of Applied Bacteriology 43, 215–30.Google Scholar
Zilberstein, D. & Dwyer, D. M. (1985). Protonmotive force-driven active transport of D-glucose and L-proline in the protozoan parasite Leishmania donovani. Proceedings of the National Academy of Sciences, USA 82, 1716–20.Google Scholar