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The role of the spleen in relation to natural and acquired immunity to infections of Babesia rodhaini in the rat

Published online by Cambridge University Press:  06 April 2009

R. S. Phillips
R. S. Phillips
Affiliation:
Department of Animal Pathology, School of Veterinary Medicine, Madingley Road, Cambridge
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Extract

In the system investigated the spleen was essential in most rats for the acquisition of immunity and its maintenance in the presence of the piroplasm.

It is stressed that model immunological systems involving the role of the spleen do not simulate the complexity of a parasitic infection. The roles of the spleen as an antibody producer, and as a site of phagocytosis and haemopoiesis are discussed in relation to the control of Babesia rodhaini by the rat. The possibility that the piroplasm may be able to undergo antigenic variation is considered.

Type
Research Article
Information
Parasitology , Volume 59 , Issue 3 , August 1969 , pp. 637 - 648
Copyright
Copyright © Cambridge University Press 1969

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References

REFERENCES

Askonas, B. A. & Humphrey, J. H. (1958). Formation of specific antibodies and γ-globulin in vitro. A study of the synthetic ability of various tissues from rabbits immunized by different methods. Biochem. J. 68, 252–61.CrossRefGoogle ScholarPubMed
Barnett, S. F. (1965). The chemotherapy of Babesia bigemina infection in cattle. Res. vet. Sci. 6, 397–415.CrossRefGoogle ScholarPubMed
Benacerraf, B., Sebestyen, M. M. & Schlossman, S. (1959). A quantitative study of the kinetics of blood clearance of P32-labelled Escherichia coli and staphylocci by the reticulo-endothelial system. J. exp. Med. 110, 27–48.CrossRefGoogle Scholar
Boyns, A. R. & Hardwicke, J. (1968). Immunological responsiveness following the continuous circulation of soluble antigen-antibody complexes. Immunology 15, 263–9.Google ScholarPubMed
Brown, K. N. & Brown, I. N. (1965). Immunity to malaria: antigenic variation in chronic infections of Plasmodium knowlesi. Nature, Lond. 208, 1286–8.CrossRefGoogle ScholarPubMed
Campbell, P. A. & La Via, M. F. (1967). Effect of splenectomy on primary and secondary response to sheep erythrocytes in rats. Proc. Soc. exp. Biol. Med. 124, 571–3.CrossRefGoogle ScholarPubMed
Cannon, D. C. & Wissler, R. W. (1967). Spleen cell migration in the immune response of the rat. Archs Path. 84, 109–18.Google ScholarPubMed
Cox, H. W., Milar, R. & Patterson, S. (1968). Serologic cross-reactions of serum antigens associated with acute Plasmodium and Babesia infections. Am. J. trop. Med. Hyg. 17, 13–19.CrossRefGoogle ScholarPubMed
Crome, P. & Mollison, P. L. (1964). Splenic destruction of Rh-sensitized and of heated red cells. Br. J. Haemat. 10, 137–54.CrossRefGoogle ScholarPubMed
De Carvalho, I. F., Borel, Y. & Miescher, P. A. (1967). Influence of splenectomy in rats on the formation of I9S and 7S antibodies. Immunology 12, 505–15.Google Scholar
Ellis, E. F. & Smith, R. T. (1966). The role of the spleen in immunity. Pediatrics, N.Y. 37, 111–19.CrossRefGoogle ScholarPubMed
Ferris, D. H., Todovoric, R. & Ristic, M. (1968). Factors associated with immunization of mice with soluble serum antigens of Plasmodium gallinaceum. Z. Tropenmed. Parasit. 19, 109–21.Google ScholarPubMed
Fitzpatrick, J. E. P., Cotton Kennedy, C., McGeown, M. G., Oreopoulos, D. G., Robertson, J. H. & Soyannwo, M. A. O. (1968). Human case of piroplasmosis (Babesiosis). Nature, Lond. 217, 861–2.CrossRefGoogle ScholarPubMed
Garnham, P. C. C. & Bray, R. S. (1959). The susceptibility of the higher primates to piroplasms. J. Protozool. 6, 361–6.CrossRefGoogle Scholar
Jacob, H. S., MacDonald, R. A. & Jandl, J. H. (1963). Regulation of spleen growth and sequestering function. J. clin. Invest. 42, 1476–90.CrossRefGoogle ScholarPubMed
Krumbhaar, E. B. (1932). The changes produced in the blood picture by removal of the mammalian spleen. Am. J. med. Sci. 184, 215–28.CrossRefGoogle Scholar
Matson, B. A. (1964). Tick transmission in Babesia divergens and immunity in B. rodhaini. Ph.D. thesis, University of Cambridge. (Summary: Vet. Bull., Weybridge (1967), 37, 97.Google Scholar
Mollison, P. L., Crome, P., Hughes-Jones, N. C. & Rochna, E. (1965). Rate of removal from the circulation of red cells sensitized with different amounts of antibody. Br. J. Haemat. 11, 461–70.CrossRefGoogle ScholarPubMed
Phillips, R. S. (1968). Studies on Babesia rodhaini in laboratory animals. Ph.D. thesis, University of Cambridge.Google Scholar
Phillips, R. S. (1969 a). The protective activity of serum from immune rats against Babesia rodhaini. Parasitology 59, 357–64.CrossRefGoogle ScholarPubMed
Phillips, R. S. (1969 b). Babesia rodhaini infections in the rat after the acute primary parasitaemia. Parasitology 59, 349–56.CrossRefGoogle ScholarPubMed
Rieber, E. E., Shields, C. E., Conrad, M. E. & Crosby, W. H. (1967). Some properties of rat erythrocytes after splenectomy and reimplanted spleens. Am. J. Physiol. 212, 897–900.CrossRefGoogle ScholarPubMed
Riek, R. F. (1963). Immunity to babesiosis. In Immunity to the Protozoa. Oxford: Blackwell.Google Scholar
Rowley, D. A. (1950). The effect of splenectomy on the formation of circulating antibody in the adult male albino rat. J. Immun. 64, 289–95.CrossRefGoogle ScholarPubMed
Skrabalo, Z. & Deanovic, Z. (1957). Piroplasmosis in man-report on a case. Documenta. Med. geogr. trop. 9, 11–16.Google Scholar
Taliaferro, W. H. (1956). Functions of the spleen in immunity. Am. J. trop. Med. Hyg. 5, 391–410.CrossRefGoogle ScholarPubMed
Todorovic, R., Ferris, D. & Ristic, M. (1967). Roles of the spleen in acute plasmodial and babesial infections in rats. Expl Parasit. 21, 354–72.CrossRefGoogle ScholarPubMed
Ultmann, J. E. & Gordon, C. S. (1965). The removal of in vitro damaged erythrocytes from the circulation of normal and splenectomized rats. Blood 26, 49–62.CrossRefGoogle ScholarPubMed
Winebright, J. & Fitch, F. W. (1962). Antibody formation in the rat. I. Agglutinin response to particulate flagella from Salmonella typhosa. J. Immun. 89, 891–9.CrossRefGoogle Scholar