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Mesocestoides corti: parameters of infection in CBA/Ca mice and the effect of introducing a concomitant trematode infection

Published online by Cambridge University Press:  06 April 2009

J. Chernin ,
Diane J. McLaren ,
A. Morinan  and
B. N. Jamieson
J. Chernin
Affiliation:
School of Biological Sciences, Portsmouth Polytechnic, King Henry Building, King Henry Street, Portsmouth, Hants PO1 2DY
Diane J. McLaren
Affiliation:
Division of Parasitology, National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 1AA
A. Morinan
Affiliation:
Department of Paramedical Sciences, North East London Polytechnic, Romford Road, London E15 4L2
B. N. Jamieson
Affiliation:
Department of Biological Sciences, North East Surrey College of Technology, Reigate Road, Ewell, Surrey KT17 3DS
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Summary

CBA/Ca mice infected with the tetrathyridia of Mesocestoides corti were exposed to Schistosoma mansoni cercariae either simultaneously, or at varying intervals after the initial M. corti infection. Cohorts were infected with either parasite alone. The dual infected mice and the mice harbouring M. corti alone were significantly heavier than either naive controls or mice carrying the S. mansoni infection only. The livers and spleens from dual infection mice were also found to be significantly heavier than those from other groups. Free M. corti tetrathyridia were reduced in number in the peritoneal cavity of dual infected mice, as compared with mice harbouring a single infection. Furthermore, the intensity of the initial M. corti infection, as measured by the number of capsules surrounding parasites in the liver, was reduced when the mice experienced an S. mansoni infection 21 days later. The mice which were exposed to M. corti only exhibited more mast cells and eosinophils around encapsulated tetrathyridia in the liver than did dual infection mice, while cells surrounding S. mansoni egg granulomas in the liver were significantly increased in dual infection mice. An increase in serum alkaline phosphatase levels was detected in both the mice receiving the dual infection and the mice with the S. mansoni only infection, but not in mice harbouring M. corti alone.

Type
Research Article
Information
Parasitology , Volume 97 , Issue 3 , December 1988 , pp. 393 - 402
Copyright
Copyright © Cambridge University Press 1988

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References

REFERENCES

Buck, A. A., Anderson, R. I. & MacRae, A. A. (1978 a). Epidemiology of poly-parasitism. I. Occurrence, frequency and distribution of multiple infections in rural communities in Chad, Peru, Afghanistan and Zaire. Tropenmedizin und Parasitologie 29, 61–70.Google ScholarPubMed
Buck, A. A., Anderson, R. I. & MacRae, A. A. (1978 b). Epidemiology of poly-parasitism. II. Types of combinations, relative frequency and associations of multiple infections. Tropenmedizin und Parasitologie 29, 137–44.Google ScholarPubMed
Buck, A. A., Anderson, R. I. & MacRae, A. A. (1978 c). Epidemiology of poly-parasitism. III. Effects on the diagnostic capacity of immunological tests. Tropenmedizin und Parasitologie 29, 145–55.Google ScholarPubMed
Chernin, J. & McLaren, D. J. (1983). The pathology induced in laboratory rats by metacestodes of Taenia crassiceps and Mesocestoides corti. Parasitology 87, 279–87.CrossRefGoogle ScholarPubMed
Chernin, J. & Morinan, A. (1985). Analysis of six serum components in rats infected with Mesocestoides corti. Parasitology 90, 441–7.CrossRefGoogle ScholarPubMed
Christensen, N. Q. & Fagberni, B. O. (1984). Trypanosoma brucei-induced blockage of expulsion of Echinostoma revolutum and of homologous E. revolutum resistance in mice. Journal of Parasitology 67, 164–6.CrossRefGoogle Scholar
Copeland, D. & Grove, D. I. (1979). Effects of Toxoplasma gondii (Gleadle strain) on the hostparasite relationship in Trichinosis. International Journal for Parasitology 9, 205–11.CrossRefGoogle ScholarPubMed
Csaba, G. (1969). Mechanism of the formation of mast cell granules. Acta Biologica Academiae Scientiarum Hungaricae 20, 205–10.Google ScholarPubMed
James, S. L. & Colley, D. G. (1978). Eosinophil-mediated destruction of Schistosoma mansoni eggs. III lymphokine involvement in the induction of eosinophil functional abilities. Cellular Immunology 38, 48–58.CrossRefGoogle ScholarPubMed
Johnson, G. R., Nicholas, W. L., Metcalf, D., McKenzie, I. F. C. & Mitchell, G. F. (1979). Peritoneal cell population of mice infected with Mesocestoides corti as a source of eosinophils. International Archives of Allergy and Applied Immunology 54, 315–22.CrossRefGoogle Scholar
Mahmoud, A. F., Strickland, G. T. & Warren, K. S. (1977). Toxoplasmosis and the host-parasite relationship in murine Schistosomiasis mansoni. Journal of Infectious Diseases 135, 408–13.CrossRefGoogle ScholarPubMed
Phillips, S. M. & Lammie, P. J. (1986). Immunopathology of granuloma formation and fibrosis in schistosomiasis. Parasitology Today 2, 296–302.CrossRefGoogle ScholarPubMed
Pollacco, S., Nicholas, W. L., Mitchell, G. F. & Steward, A. C. (1978). T-cell dependent collagenous encapsulating response in the mouse liver to Mesocestoides corti (Cestoda). International Journal for Parasitology 8, 457–62.CrossRefGoogle ScholarPubMed
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology 55, 695–700.CrossRefGoogle ScholarPubMed
Sirag, S. B., Christensen, N. Q., Frandsen, F., Monrad, J. & Nansen, P. (1980). Homologous and heterologous resistance in Echinostoma revolutum infections in mice. Parasitology 80, 479–86.CrossRefGoogle ScholarPubMed
Strickland, G. T., Voller, A., Pettit, L. E. & Fleck, D. G. (1972). Immunodepression associated with concomitant Toxoplasma and malarial infections in mice. Journal of Infectious Diseases 126, 54–60.CrossRefGoogle ScholarPubMed