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The evolution of acquired immunity to parasites

Published online by Cambridge University Press:  06 April 2009

N. A. Mitchison
N. A. Mitchison
Affiliation:
Imperial Cancer Research Fund, Tumour Immunology Unit, University College London, Gower Street, London WC1E 6BT
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Summary

Evolutionary pressures exerted by parasites on the immune system, and vice versa, are surveyed from a speculative viewpoint. New information is presented about the possible channelling of suppression by MHC Class II genes in the mouse, where a novel pattern of dominant unresponsiveness mediated by H-2Ab is described. In addition, the hypothesis is advanced that phosphatidyl–inositol anchorage on the surface of parasites may represent a novel evasion mechanism, in which the spread of the immune response by epitope linkage is inhibited by host phospholipase.

Keywords

immunityevasion mechanismepitope linkagephospholipid
Type
Research Article
Information
Parasitology , Volume 100 , Issue S1: Symposia of the British Society for Parasitology Volume 27:The evolutionary biology of parasitism , June 1990 , pp. S27 - S34
Copyright
Copyright © Cambridge University Press 1990

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