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The anti-neoplastic effect of trichinellosis in a syngeneic murine model

Published online by Cambridge University Press:  06 April 2009

Dorothy Pocock  and
Eugene Meerovitch
Dorothy Pocock
Affiliation:
The Institute of Parasitology, McGill University, Macdonald College, Ste. Anne de Bellevue, P. Q, Canada H9X 1C0
Eugene Meerovitch
Affiliation:
The Institute of Parasitology, McGill University, Macdonald College, Ste. Anne de Bellevue, P. Q, Canada H9X 1C0
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Summary

C57B1/6 male mice with chronic trichinellosis, and age-matched uninfected control mice, were inoculated with B16 melanoma cells. Tumour development was inhibited in the infected animals. In the infected tumour-bearing mice, the tumour induction intervals were longer and the tumour size was subsequently smaller than in the control mice. Moreover, when the number of tumour cells in the inoculum was less than that required to produce 100% tumour incidence in the uninfected mice (<1 × 104 cells), significantly more of the mice with an infection of 2 months duration remained tumour-free. These results were significant at the P<0·05 level.

Type
Research Article
Information
Parasitology , Volume 84 , Issue 3 , June 1982 , pp. 463 - 473
Copyright
Copyright © Cambridge University Press 1982

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References

Allison, A. C., (1978). Macrophage activation and nonspecific immunity. International Review of Experimental Pathology 18, 303–46.Google ScholarPubMed
Clark, E. A., & Harmon, R. C., (1980). Genetic control of natural cytotoxicity and hybrid resistance. Advances in Cancer Research 31, 228–285.Google ScholarPubMed
Despommier, D. D., Sukhdeo, M. V. K., & Meerovitch, E., (1978). Trichinella spiralis: site selection by the larva during the enteral phase of infection in mice. Experimental Parasitology 44, 209–15.CrossRefGoogle ScholarPubMed
Eugui, E. M., & Allison, A. C., (1980). Differences in susceptibility of various mouse strains to haemoprotozoan infections: possible correlation with natural killer cell activity. Parasite Immunology 2, 277–92.CrossRefGoogle Scholar
Fidler, I. J., Gersten, D. M., & Hart, I. R., (1978). The biology of cancer invasion and metastasis. Advances in Cancer Research 28, 149–250.CrossRefGoogle ScholarPubMed
Herberman, R. B., & Holden, H. T., (1978). Natural cellmediated immunity. Advances in Cancer Research 27, 305–77.CrossRefGoogle Scholar
Hewitt, H. B., (1978). The choice of animal tumors for experimental studies of cancer therapy. Advances in Cancer Research 27, 149–200.CrossRefGoogle ScholarPubMed
Keller, R., Ogilvie, B. M., & Simpson, E., (1971). Tumour growth in nematode infected animals. Lancet 7701, 678–80.CrossRefGoogle Scholar
Kiessling, R., & Wigzell, H., (1979). An analysis of the murine NK cell as to structure, function and biological relevance. Immunological Reviews 44, 165–208.CrossRefGoogle ScholarPubMed
Mebrovitch, E., & Bomford, R., (1977). Macrophage potentiation by Trichinella spiralis. Annals of Tropical Medicine and Parasitology 71, 245–7.CrossRefGoogle Scholar
Molinari, J. A., & Ebersole, J. L., (1977). Antineoplastic effects of long-term Trichinella spiralis infection on B-16 melanoma. International Archives of Allergy and Applied Immunology 55, 444–8.CrossRefGoogle ScholarPubMed
Nakano, K., Nakamura, I., & Cudkowicz, G., (1981). Generation of F1 hybrid cytotoxic T lymphocytes specific for self H-2. Nature, London 289, 559–63.CrossRefGoogle ScholarPubMed
Schrek, R., (1979). Utility and efficiency of viable cell counts. Cancer Research 39, 4288.Google ScholarPubMed
Siegel, S., (1956). Nonparametric Statistics for the Behavioural Sciences. New York, Toronto and London: McGraw-Hill.Google Scholar
Sokal, R. R., & Rohlf, F. J., (1969). Biometry. San Francisco: W. H. Freeman and Company.Google Scholar
Staats, J., (1976). Standardized nomenclature for inbred strains of mice; sixth listing. Cancer Research 36, 4333–77.Google ScholarPubMed
Weatherly, N. F., (1970). Increased survival of Swiss mice given sublethal infections of Trichinella spiralis. Journal of Parasitology 56, 748–52.CrossRefGoogle ScholarPubMed
Wing, E. J., Krahenbuhl, J. L., & Remington, J. S., (1979). Studies of macrophage function during Trichinella spiralis infection in mice. Immunology 36, 479–85.Google ScholarPubMed
Wright, K. A., (1979). Trichinella spiralis: an intracellular parasite in the intestinal phase. Journal of Parasitology 65, 441–5.CrossRefGoogle ScholarPubMed