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Phase Inversion Dynamics of PLGA Solutions Related to Drug Delivery

Published online by Cambridge University Press:  15 February 2011

A.J. Mchugh ,
P.D. Graham  and
K.J. Brodbeck
A.J. Mchugh
Affiliation:
Chemical Engineering Department, University of Illinois, Urbana, IL 61801, [email protected]
P.D. Graham
Affiliation:
Chemical Engineering Department, University of Illinois, Urbana, IL 61801
K.J. Brodbeck
Affiliation:
Chemical Engineering Department, University of Illinois, Urbana, IL 61801
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Abstract

Dark ground optical microscopy, electron microscopy, and protein release rate studies have been used to quantify the effects of formulation changes on the phase inversion dynamics and in vitro drug release properties of an injectable PLGA-based drug delivery system. Gel growth rates and water influx rates are determined from plots of the square of the respective front with time. Results show that additives that increase the solution gelation rate and produce finger-like void morphologies result in higher initial release rates. Conversely, additives that slow the rate of gelation dramatically reduce the initial drug release rate and lead to a more dense sponge-like morphology.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 41
Copyright
Copyright © Materials Research Society 1999

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References

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