Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-28T15:15:53.446Z Has data issue: false hasContentIssue false
  • English
  • Français

Fabricating Neural and Cardiomyogenic Stem Cell Structures by a Novel Rapid Prototyping—the Inkjet Printing Method

Published online by Cambridge University Press:  01 February 2011

Tao Xu ,
Cassie Gregory ,
Peter Molnar  and
Thomas Boland
Tao Xu
Affiliation:
Department of Bioengineering, Clemson University Clemson, SC 29634-0905, U.S.A.
Cassie Gregory
Affiliation:
Department of Bioengineering, Clemson University Clemson, SC 29634-0905, U.S.A.
Peter Molnar
Affiliation:
Department of Bioengineering, Clemson University Clemson, SC 29634-0905, U.S.A.
Thomas Boland
Affiliation:
Department of Bioengineering, Clemson University Clemson, SC 29634-0905, U.S.A.
Get access

Abstract

Direct printing of living cardiomyogenic stem cells and embryonic cortical neurons to generate complex cellular patterns and structures of such cells was demonstrated in the study. Furthermore, the immunostaining analyses and the whole-cell patch clamp recordings showed the cortical neurons grown in the printed cellular patterns and structures maintained their basic cellular functions, including neuronal phenotypes and electrophysiological properties. These results and findings may greatly prompt the inkjet printing method evolving into a viable and cost-effective approach for engineering human neural and cardiac tissues or even organs.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA1.4
Copyright
Copyright © Materials Research Society 2005

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

[1] Taylor, J. P., Hardy, J., Fischbeck, K. H., Science 296 (2002) 1991–1995.Google Scholar
[2] Kessler, P. D., Byrne, B. J., Annual Review of Physiology 61 (1999) 219–242.Google Scholar
[3] Fuchs, J. R., Nasseri, B. A., Vacanti, J. P., Annals of Thoracic Surgery 72 (2001) 577–591.Google Scholar
[4] Xu, T., Jin, J., Gregory, C., Hickman, J. J., Boland, T., Biomaterials 26 (2005) 93–96.Google Scholar
[5] Roth, E. A., Xu, T., Das, M., Gregory, C., Hickman, J. J., Boland, T., Biomaterials 25 (2004) 3707–3715.Google Scholar
[6] Wilson, W. C., Boland, T., Anatomical Record 272A (2003) 491–496.Google Scholar
[7] Eisenberg, C. A., Markwald, R. R., Developmental Biology 191 (1997) 167–181.Google Scholar
[8] Varghese, D., Deshpande, M., Xu, T., Kesari, P., Ohri, S., Boland, T., Journal of Thoracic and Cardiovascular Surgery In press (2005).Google Scholar