Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-25T19:05:50.011Z Has data issue: false hasContentIssue false

Advances in the Materials Science of Skin: A Composite Structure with Multiple Functions

Published online by Cambridge University Press:  31 January 2011

Get access

Abstract

This article gives the foundation for understanding the structure and function of human skin and its layers. Skin is our first line of defense against the penetration of external chemicals and bacteria into the body and of water loss from the body. Skin's visual and tactile properties are very much linked to appearance and beauty. Skin treatments as simple as washing with soap affect the mechanics of skin properties, making it dry and brittle versus smooth and elastic. Likewise, natural aging, hormonal changes, and sun exposure affect the properties of skin. Mild cleansing, moisturizer treatments, and regular use of sunscreens can, however, help skin maintain and even improve its quality, appearance, and functional properties.

Type
Research Article
Copyright
Copyright © Materials Research Society 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Elias, P.M., in Skin Barrier, Elias, P.M., Feingold, K.R., Eds. (Taylor Francis Group, New York, 2006) p. 5.Google Scholar
2.Harding, C., Dermatol. Ther. 17 (6), 6 (2004).Google Scholar
3.Elias, P.M., J. Invest. Dermatol. 80, 44s (1983).Google Scholar
4.Weinstein, G.D., McCullough, J.L., Ross, P., J. Invest. Dermatol. 82 (6), 623 (1984).CrossRefGoogle Scholar
5.Jarnik, M., Simon, M.N., Steven, A.C., J. Cell. Sci. 111, 1051 (1998).CrossRefGoogle Scholar
6.Neimes, Z., Steinert, P.M., Exp. Mol. Med. 31, 5 (1999).Google Scholar
7.Reichert, U., Michel, S., Schmidt, R., Molecular Biology of the Skin: The Keratinocyte, Darmon, M., Blumenberg, M., Eds. (Academic Press, San Diego, 1993), p. 107.Google Scholar
8.Serre, G., Mills, V., Haftek, M., Vincent, C., Croute, F., Reano, A., Quahayoun, J.P., Bettinger, S., Soleilhavoup, J.P., Invest. Dermatol. 97, 1061 (1991).Google Scholar
9.Egelrud, T., Acta Derm. Venereol. 80 (1), 44 (2000).Google Scholar
10.Lundstrom, A., Egelrud, T., J. Invest. Dermatol. 91, 340 (1988).CrossRefGoogle Scholar
11.Lavker, R.M., J. Ultra. Res. 55, 79 (1976).Google Scholar
12.Landmann, L., J. Invest. Dermatol. 87, 202 (1986).CrossRefGoogle Scholar
13.Bouswstra, J.A., Pilgram, G.S.K., Ponec, M., in Skin Barrier, Elias, P.M., Feingold, K.R., Eds. (Taylor Francis Group, New York, 2006) p. 65.Google Scholar
14.Norlen, L., J. Invest. Dermatol. 117 (4), 823 (2001).CrossRefGoogle Scholar
15.Norlen, L., J. Invest. Dermatol. 117 (4), 830 (2001).Google Scholar
16.Norlen, L., Al-Amoudi, A., J. Invest. Dermatol. 123 (4), 715 (2004).CrossRefGoogle Scholar
17.Braverman, I.M., J. Invest. Dermatol. 93, 2s (1989).CrossRefGoogle Scholar
18.Elias, P.M., Friend, D.S., J. Cell Biology 65, 180 (1975).CrossRefGoogle Scholar
19.Grubauer, G., Feingold, K.R., Harris, R.M., Elias, P.M., J. Lipid Res. 30, 89 (1989).Google Scholar
20.Leveque, J., in Bioengineering of the Skin: Water and the Stratum Corneum, Elsner, P., Berardesca, E., Maibach, H.I., Eds. (CRC Press, Boca Raton, Fla., 1994) p. 13.Google Scholar
21.Harding, C.R., Scott, I.R., J. Mol. Biol. 170, 651 (1983).CrossRefGoogle Scholar
22.Guyton, A.C., Hall, J.E., Textbook of Medical Physiology (W.B. Saunders, London, 2000).Google Scholar
23.Papir, Y.S., Hsu, K.H., Wildnauer, R.H., Biochim. Biophys. Acta 399 (1), 170 (1975).CrossRefGoogle Scholar
24.Petko, M., Unilever Research and Development (1990), unpublished results.Google Scholar
25.Hermes, R., Bauer, K.H., Pharmazie 50, 481 (1995).Google Scholar
26.Moore, D.J., Recent Res. Develop. Lipids 6, 55 (2002).Google Scholar
27.Ota, Y., Fukumashi, A., Nishimura, Y., Nakamura, K., J. Soc. Fiber Sci. Technol., Jpn. 52, 1 (1996).Google Scholar
28.Koutrooupi, K.S., Barabenel, J.C., J. Biomech. 23 (3), 281 (1990).CrossRefGoogle Scholar
28.Ananthapadmanabhan, K.P., Subramanyan, K., Rattinger, G.B., in Skin Moisturisation: Cosmetic Science & Technology Series, Leyden, L.J., Rawlings, A.V., Eds., 25 (Marcel Dekker, New York, 2002) p. 405.Google Scholar
30.Mukherjee, S., Richardson, N., Margosiak, M., Lei, X., in Supramolecular and Colloidal Structures in Biomaterials and Biosubstrates: Proc. Fifth Royal Society-Unilever Indo-UK Forum in Material Science and Engineering, Lal, M., Lilford, P.J., Naik, V.M., Prakash, V., Eds. (Imperial College Press, the Royal Society, London, 1999) p. 306.Google Scholar
31.Wu, K.S., Stefik, M.M., Ananthapad-manabhan, K.P., Dauskardt, R.H., Biomaterials 27, 5861 (2006).Google Scholar
32.Ananthapadmanabhan, K.P., Lips, A., Vincent, C., Meyer, F., Caso, S., Johnson, A., Subramanyan, K., Vethamuthu, M., Rattinger, G., Moore, D.J., Int. J. Cosmet. Sci. 25, 103 (2003).CrossRefGoogle Scholar
33.Adams, M.J., Briscoe, B.J., Johnson, S.A., Tribol. Lett. 26 (3), 239 (2007).Google Scholar
34.Pierard, G.E., Letawe, C., Dowlati, A., Pierardfranchimount, C., J. Am. Geriatr. Soc. 43, 662 (1995).Google Scholar
35.Yaar, M., Gilchrest, B.A., J. Invest. Dermatol. Symp. Proc. 3, 47 (1998).Google Scholar
36.Lips, A., Ananthapadmanabhan, K.P., Vethamuthu, M., Hua, X.Y., Yang, L., Vincent, C., Deo, N., Somasundaran, P., in Surfactant Science Series, Rhein, L.D., Schlossman, M., O'Lenick, A., Somasundaran, P., Eds., 135 (CRC Press, Boca Raton, Fla., 2007) p. 177.Google Scholar
37.Imokawa, G., in Surfactant Science Series, Rieger, M.M., Rhein, L.D., Eds. (Marcel Dekker, New York, 1997) p. 427.Google Scholar
38.Rhein, L.D., in Surfactant Science Series, Rieger, M.M., Rhein, L.D., Eds. (Marcel Dekker, New York, 1997) p. 397.Google Scholar
39.Frosch, P.J., Kligman, A.M., J. Am. Acad. Dermatol. 1, 35 (1979).CrossRefGoogle Scholar
40.Nole, G., Johnson, A.W., Dermatol. Ther. 17, 57 (2004).Google Scholar
41.Stiller, M.J., Bartolone, J., Stern, R., Smith, S., Kollias, N., Gillies, R., Drake, L.A., Arch. Dermatol. 132 (6), 631 (1996).CrossRefGoogle Scholar
42.Bisset, D.L., Robinson, L.R., Raleigh, P.S., Miyamoto, K., Hakzaki, T., Li, J., Kelm, G.R., J. Cosmet. Dermatol. 6, 20 (2007).Google Scholar
43.Mitragotri, S., J. Control. Release 86, 69 (2003).Google Scholar
44.Schaefer, H., Redelmeier, T.E., Skin Barrier: Principles of Percutaneous Absorption (Karger, Basel, 1996) p. 101.Google Scholar
45.Ruland, A., Rohr, U., Kreuter, J., Int. J. Pharm. 107, 23 (1984).CrossRefGoogle Scholar
46.Sah, A., Mukherjee, S., Wickett, R.R., J. Cosmet. Sci. 49, 257 (1998).Google Scholar
47.Menon, G.K., Elias, P.M., Skin Pharmacol. 10, 235 (1997).CrossRefGoogle Scholar
48.Honeywell-Nguyen, P.L., de Graaff, A.M., Groenink, H.W.W., Bouwstra, J.A., Biochim. Biophys. Acta 1573, 130 (2002).CrossRefGoogle Scholar
49.Lademann, J., Otberg, N., Richter, H., Weigmann, H., Lindemann, U., Scaefer, H., Sterry, W., Skin Pharmacol. Appl. Skin Physiol. 14 (1), 17 (2001).Google Scholar
50.Mukherjee, S., Unilever, unpublished results.Google Scholar
51.Mukherjee, S., Rick, D., Habif, S., R.Weinkauf, “Skin cosmetic compositions containing dextran or maltodextrin and a weak carboxylic acid,” U.S. patent 6,440,432 B1 (August 27, 2002).Google Scholar