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Measurement of Oxidation of Biomolecules and Inactivation of Bioparticles in Aqueous Media by Radicals Injected from Electrical Discharge Devices

Published online by Cambridge University Press:  01 February 2016

Hirofumi Kurita  and
Akira Mizuno
Hirofumi Kurita
Affiliation:
Toyohashi University of Technology, 1-1 Tempaku-cho, Toyohashi, Aichi 441-8580, JAPAN
Akira Mizuno*
Affiliation:
Toyohashi University of Technology, 1-1 Tempaku-cho, Toyohashi, Aichi 441-8580, JAPAN
*
*(Email: [email protected])
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Abstract

Recently, commercial home electric appliances with bactericidal/viral inactivation function of room air have been widely available. Most of these home appliances equip discharge devices which possibly generate reactive oxygen and nitrogen oxides. However, these effects are still controversial problem. To elucidate the inactivation effect of these devices at molecular level, we have been considering large DNA molecules as a biomarker to be used. By exposing DNA solution to the gas containing the chemical species, oxidative damage to DNA such as strand breaks can be induced. We have conducted the single-molecule-based evaluation method of DNA strand break using large linear DNA molecules. The obtained breakage rate could possibly be used for evaluation of reactivity of radicals generated by the discharge devices.

Keywords

oxidationliquidbiological
Type
Articles
Information
MRS Advances , Volume 1 , Issue 18: Biomaterials and Soft Materials , 2016 , pp. 1271 - 1275
Copyright
Copyright © Materials Research Society 2016 

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References

REFERENCES

Nishimura, H., J. Jpn. Assoc. Infect. Dis., 86, 723–733 (2012) (in Japanese)Google Scholar
Kurita, H., Nakajima, T., Yasuda, H., Takashima, K., Mizuno, A., Wilson, J. I. B., and Cunningham, S., Appl. Phys. Lett., 99, 191504 (2011).Google Scholar
Kurita, H., Shimizu, M., Sano, K., Nakajima, T., Yasuda, H., Takashima, K., and Mizuno, A., Jpn. J. Appl. Phys., 53, 05FR01A (2014).Google Scholar
Oshige, M., Yamaguchi, K., Matsuura, S., Kurita, H., Mizuno, A., and Katsura, S., Anal. Biochem., 400, 145–147 (2010).Google Scholar
This paper is originally published as the following paper: Kurita, H. and Mizuno, A., J. Inst. Electrostat. Jpn., 37, 144–149 (2013) (in Japanese)Google Scholar