Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-28T10:06:54.495Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of Particle Sizes and Natural Polymers on Mechanical Properties of Alpha Tricalcium Phosphate Cements

Published online by Cambridge University Press:  11 April 2016

Shota Ishii ,
Tomoaki Sugiyama ,
Jeffrey S. Cross  and
Toshiyuki Ikoma
Shota Ishii*
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552 Japan
Tomoaki Sugiyama
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552 Japan
Jeffrey S. Cross
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552 Japan
Toshiyuki Ikoma
Affiliation:
Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8552 Japan
*
*(Email: [email protected])
Get access

Abstract

Calcium phosphate cements show self-hardening reaction upon mixing with liquids to form calcium-deficient hydroxyapatite (CDHA) or dicalcium phosphate dihydrate. The effects of particle sizes, crystallinities, and natural polymers such as tilapia scale collagen (Col) and hyaluronic acid as a dispersant on the mechanical properties of alpha tricalcium phosphate (TCP) cements mixed with citric acid (CA) as an additive were investigated. Three types of alpha TCP particles were fabricated with spray-dry (SD; 14 μm), freeze-dry (FD; 45 μm), and cold isostatic press (CIP; 134 μm) methods, followed by sintering at 1300°C and ground/crushed. The amounts of Ca dissolution from these particles were in the order of SD > FD > CIP. The CA liquid was added to the powders of SD-FD or SD-CIP, and kneaded under different liquid/powder ratios. The cements containing CIP particles showed lower compressive strength at 22.9 ± 1.5 MPa than those containing FD particles at 28.3 ± 2.5 MPa, even though the apparent densities of the cements containing CIP material was higher. Although the packing density of powders is an important factor on the mechanical properties of cements, the dissolution of Ca ion has a greater impact on the mechanical properties. The addition of Col into the cements increased the mechanical properties at 33.6 ± 2.5 MPa at 1 day to enhance the re-precipitation of CDHA.

Keywords

biomaterialpolymergrain size
Type
Articles
Information
MRS Advances , Volume 1 , Issue 18: Biomaterials and Soft Materials , 2016 , pp. 1277 - 1282
Copyright
Copyright © Materials Research Society 2016 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Monma, H. and Kanazawa, T., Yogyo-Kyokai-shi 84, 209–213 (1976).CrossRefGoogle Scholar
Tien, Y.C., Chih, T.T., Lin, J.H.C., Ju, C.P., Lin, S.D., J. Bone Joint SUrg. Br. 86B, 1072–1076 (2004).CrossRefGoogle Scholar
Takechi, M. et al. Initial histological evaluation of anti-washout type fast-setting calcium phosphate cement following subcutaneous implantation. Biomaterials 19, 2057–2063 (1998).CrossRefGoogle ScholarPubMed
Zhang, J., Liu, W., Schnitzler, V., Tancret, F., Bouler, J.M., Acta Biomaterialia, 10, 1035–1049 (2014).CrossRefGoogle Scholar
Brunner, T.J., Grass, R.N., Bohner, M., Stark, W.J., J. Mater. Chem., 17, 4072–4078 (2007).CrossRefGoogle Scholar
Bohner, M., J. Mater. Chem., 17, 3980–3986 (2007).CrossRefGoogle Scholar
Torres, P.M.C., Gouveia, S., Olhero, S., Kaushal, A., Ferreira, J.M.F., Acta Biomaterialia, 21, 204–216 (2015)CrossRefGoogle Scholar
Yokoyama, A., Yamamoto, S., Kawasaki, T., Kohgo, T., Nakasu, M., Biomaterials, 23, 1091–1101 (2002).CrossRefGoogle Scholar
Barralet, F.E., Tremayne, M., Lilley, K.J., Gbureck, U., Chem. Mater., 17, 1313–1319 (2005).CrossRefGoogle Scholar
Perez, R.A., Kim, H.W., Ginebra, M.P., J. Tissue Eng., DOI:10.1177/2041731412439555 (2012).Google Scholar
Miyamoto, Y., Ishikawa, K., Takeuchi, M., Taketomo, T., Yuasa, T., Nagayama, M., Suzuki, K., Biomaterials, 19, 707–715 (1998).CrossRefGoogle Scholar
Alkhraisat, M.H., Rueda, C., Marino, F.T., Torres, J., Jerez, L.B., gbureck, U., Cabarocs, E.L., Acta Biomater., 5, 3150–3156 (2009).CrossRefGoogle Scholar
Kai, D., Li, D., Zhu, X., Zhang, L., Fan, H., Zhang, X.J. Mater. Sci. Mater. Med., 20, 1595–1602 (2009).CrossRefGoogle Scholar
Suzuki, M., J. Soc. Powder Technol., Japan, 40, 348–354 (2003) in Japanese.CrossRefGoogle Scholar