Starting in late September 1872, horses started falling ill with a severe respiratory complaint in the countryside about a dozen miles north of Toronto, Ontario. Veterinary experts swiftly diagnosed the malady, which paralyzed street transportation, commerce, and everyday life in Toronto itself during the first weeks of October, as influenza. Over the next year, an equine plague that most contemporaries referred to as the epizootic—and which I call the Great Horse Flu in the book I am completing on this outbreak—spread throughout southern Canada, every reach of the United States, and parts of Cuba, Mexico, and Central America. The novel influenza virus responsible for this outbreak sickened between ninety and ninety-nine percent of horses, donkeys, and mules across this vast swath of the northern Americas.1 Our best guess is that the Great Horse Flu killed between one and four percent of the equines it afflicted—a case fatality rate roughly not unlike those recorded by the Great Influenza Pandemic of 1918–1920 and the COVID Pandemic. In less than a year, an estimated 112,500 to 554,000 horses and ponies perished alongside tens or hundreds of thousands of mules and donkeys.2

Sometimes male ostriches emit a low guttural sound that sounds strangely like a lion. On the plains in South Africa, these sounds aimed at female ostriches might confuse an unknowing listener. But on a ship bound from South Africa to Galveston, Texas in February 1887, these lion-esque sounds would not have been heard. Instead, as these dozens of ostriches crossed the Atlantic, their vocalizations were probably a quiet chirp, despite each bird weighing well over 100 pounds. Each ostrich had a more solitary existence on the ship than they had experienced in the wild or on a South African farm. On the Atlantic, they lived in single padded stalls near the middle of the hold, with paddocks between the stalls to offer some exercise and perhaps some interaction among the birds.1

In winter of 1900, the famed nature writer Ernest Thompson Seton lived briefly in a log cabin built in the middle of the National Zoological Park, located just north of the White House. The small lodging was placed between the muddied bison paddocks and the denuded deer and antelope yards.

Two of the world’s greatest boxers—Muhammad Ali of Louisville, KY and George Foreman of Houston, TX—met for the legendary “Rumble in the Jungle” in Kinshasa, Zaire (now the Democratic Republic of Congo) in 1974. With concerts by the African American “Godfather of Soul” James Brown and South African singer-songwriter Miriam Makeba, nicknamed “Mama Africa,” the entwining tones of the U.S. civil rights era and anti-Apartheid movement augmented a cultural moment that displayed Pan-African, Black nationalist, and anti-imperial connections. However, the appearance of an insidious symbol from each aforementioned era is what decidedly swayed the local population against Foreman and for Ali.1

In a private 1972 report to the Director of the National Park Service, Jack Anderson, Superintendent of Yellowstone National Park, confessed that “we are apprehensive that their proposal would ultimately end up with the complete slaughter of all bison, as occurred on the Crow Indian Reservation.”1 For decades, livestock producers at the local and national level pressured park officials to eliminate a specific disease—brucellosis caused by Brucella abortus—from Yellowstone’s buffalo herds. Following World War II, governments targeted this bacterial contagion in American domestic and wild animal populations to improve public health and livestock producers’ profits. Symptoms of brucellosis, which humans can catch from other mammalian hosts, vary across species. For domestic cattle, it can cause spontaneous abortions and, in rare cases, death. Buffalo seem largely unaffected by brucellosis but for humans, the bacterial infection can cause a plethora of chronic and debilitating symptoms.2