Over the last ten years, molecular biologists and computer scientists have experimented with various artificial intelligence techniques, notably knowledge based and expert systems, qualitative simulation, natural language processing and various machine learning techniques. These techniques have been applied to problems in molecular data analysis, construction of advanced databases and modelling of biological systems. Practical results are now being obtained, notably in the representation and recognition of genetically significant structures, the assembly of genetic maps and prediction of the structure of complex molecules such as proteins. The paper outlines the principal methods used, surveys the findings to date, and identifies promising trends and current limitations.