Human immunodeficiency virus (HIV)-infected adults frequently evidence
both neurocognitive and psychiatric dysfunction. It was hypothesized that
apathy and irritability, but not anxiety and depression, are related to
HIV effects on frontal–subcortical systems. This hypothesis was
evaluated by determining the degree to which these psychiatric features
are associated with neurocognitive functioning that is dependent upon
frontal–subcortical circuitry and, therefore, thought to be
sensitive to the central nervous system effects of HIV. Rating scales
assessing irritability, apathy, depression, and anxiety and a dual-task
paradigm were administered to 189 HIV-seropositive (HIV+) and 53
HIV-seronegative participants. Deficits in dual-task performance and
greater anxiety, depression, apathy, and irritability were observed in
HIV+ participants. Simultaneous multivariate regression and communality
analyses revealed that only apathy and irritability were associated with
dual-task performance in HIV+ participants. Thus, these findings suggest
that apathy and irritability, but not depression and anxiety, are likely
associated with the effects of HIV on frontal–subcortical circuitry.
(JINS, 2007, 13, 549–554.)