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A longitudinal study of language decline in Alzheimer's disease and frontotemporal dementia

Published online by Cambridge University Press:  02 February 2007

MERVIN BLAIR ,
CECILE A. MARCZINSKI ,
NICOLE DAVIS-FAROQUE  and
ANDREW KERTESZ
MERVIN BLAIR
Affiliation:
Department of Cognitive Neurology, St. Joseph's Health Care, London, Ontario, Canada
CECILE A. MARCZINSKI
Affiliation:
Department of Psychology, University of Kentucky, Lexington, Kentucky.
NICOLE DAVIS-FAROQUE
Affiliation:
Department of Cognitive Neurology, St. Joseph's Health Care, London, Ontario, Canada
ANDREW KERTESZ
Affiliation:
Department of Cognitive Neurology, St. Joseph's Health Care, London, Ontario, Canada
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Abstract

Language decline is usually the fastest and predominant change in primary progressive aphasia (PPA). In Alzheimer's disease (AD), it is usually associated with global cognitive deficits. Decreased speech output, reduced conversational initiation, echolalia, and changes in the pragmatics of conversation are seen in the behavioral variant of frontotemporal dementia (FTD-bv), however, the evolution of language disturbance in FTD-bv patients is rarely examined systematically with a standardized language battery. We aimed to longitudinally track the nature of language change in FTD-bv, PPA, and AD using a standardized measure of language functioning. We also explored the nature of language deficits between semantic dementia (SD) patients and the fluent subgroup of PPA patients. The Western Aphasia Battery was administered to 105 AD, 20 FTD-bv, 54 PPA, and 10 SD patients on 2 occasions with approximately 1 year between assessments. Ninety-nine of these patients were examined an additional year. FTD-bv and PPA patients showed a faster language decline than AD patients. The eventual overlap in language functioning in FTD-bv and PPA suggests that these syndromes belong to the same spectrum of disorders. In conclusion, longitudinal language assessment provides us with a unique understanding of the evolution and progression of language deterioration in various dementias. (JINS, 2007, 13, 237–245.)

Keywords

Frontotemporal lobar degenerationPrimary progressive aphasiaProgressive nonfluent aphasiaSemantic dementiaAlzheimer's type dementiaWestern Aphasia Battery
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 2 , March 2007 , pp. 237 - 245
Copyright
© 2007 The International Neuropsychological Society

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References

REFERENCES

Alzheimer, A. (1907). On a peculiar disease of the cerebral cortex. Allgemeine Zeitschrift fur Psychiatrie und Psychish-Gerichtlich. Medicin, 64, 146–148.Google Scholar
Appell, J., Kertesz, A., & Fisman, M. (1982). A study of language functioning in Alzheimer patients. Brain and Language, 17, 73–91.Google Scholar
Ash, S., Moore, P., Antani, S., McCawley, G., Work, M., & Grossman, M. (2006). Trying to tell a tale: Discourse impairments in progressive aphasia and frontotemporal dementia. Neurology, 66, 1405–4013.Google Scholar
Bird, H., Lambon Ralph, M.A., Patterson, K., & Hodges, J.R. (2000). The rise and fall of frequency and imageability: Noun and verb production in semantic dementia. Brain and Language, 73, 17–49.Google Scholar
Bowler, J.V., Munoz, D.G., Merskey, H., & Hachinski, V. (1998). Fallacies in the pathological confirmation of the diagnosis of Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 64, 18–24.Google Scholar
Cummings, J.L., Benson, F., Hill, M.A., & Read, S. (1985). Aphasia in dementia of the Alzheimer type. Neurology, 35, 394–397.Google Scholar
Frattali, C.M., Grafman, J., Patronas, N., Makhlouf, F., & Litvan, I. (2000). Language disturbances in corticobasal degeneration. Neurology, 54, 990–992.Google Scholar
Grossman, M., Mickanin, J., Onishi, K., Hughes, E., D'Esposito, M., Ding, X-S., Alavi, A., & Reivich, M. (1996). Progressive nonfluent aphasia: Language, cognitive, and PET measures contrasted with probable Alzheimer's disease. Journal of Cognitive Neuroscience, 8, 135–154.Google Scholar
Grossman, M. & Moore, P. (2005). A longitudinal study of sentence comprehension difficulty in primary progressive aphasia. Journal of Neurology, Neurosurgery and Psychiatry, 76, 644–649.Google Scholar
Gustafson, L. (1987). Frontal lobe degeneration of non-Alzheimer type. II. Clinical picture and differential diagnosis. Archives of Gerontology and Geriatrics, 6, 209–223.Google Scholar
Gustafson, L. (1993). Clinical picture of frontal lobe degeneration of non-Alzheimer type. Dementia, 4, 143–148.Google Scholar
Hodges, J.R. (2001). Frontotemporal dementia (Pick's disease): Clinical features and assessment. Neurology, 56, 11, Suppl. 4, S6–10.Google Scholar
Hodges, J.R., Davies, R.R., Xuereb, J.H., Casey, B., Broe, M., Bak, T.H., Kril, J.J., & Halliday, G.M. (2004). Clinicopathological correlates in frontotemporal dementia. Annals of Neurology, 56, 399–406.Google Scholar
Hodges, J.R. & Patterson, K. (1996). Nonfluent progressive aphasia and semantic dementia: A comparative neuropsychological study. Journal of the International Neuropsychological Society, 2, 511–524.Google Scholar
Hodges, J.R., Patterson, K., Oxbury, S., & Funnell, E. (1992). Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain, 115, 1783–1806.Google Scholar
Hodges, J.R., Patterson, K., Ward, R., Garrard, P., Bak, T., Perry, R., & Gregory, C. (1999). The differentiation of semantic dementia and frontal lobe dementia (temporal and frontal variants of frontotemporal dementia) from early Alzheimer's disease: A comparative neuropsychological study. Neuropsychology, 13, 31–40.Google Scholar
Howard, D. & Patterson, K. (1992). Pyramids and Palm Trees: A test of semantic access from pictures and words. Bury St, Edmunds, Suffolk: Thames Valley Test Company.
Josephs, K.A., Petersen, R.C., Knopman, D.S., Boeve, B.F., Whitwell, J.L., Duffy, J.R., Parisi, J.E., & Dickson, D.W. (2006). Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP. Neurology, 66, 41–48.Google Scholar
Karbe, H., Kertesz, A., & Polk, M. (1993). Profiles of language impairment in primary progressive aphasia. Archives of Neurology, 50, 193–201.Google Scholar
Kertesz, A. (1982). The Western Aphasia Battery. New York: Grune & Stratton.
Kertesz, A. (2003). Pick Complex: An integrative approach to frontotemporal dementia—Primary progressive aphasia, corticobasal degeneration, and progressive supranuclear palsy. The Neurologist, 9, 311–317.Google Scholar
Kertesz, A., Appell, J., & Fisman M. (1986). The dissolution of language in Alzheimer's disease. Canadian Journal of Neurological Sciences, 13, 415–418.Google Scholar
Kertesz, A., Davidson, W., & Fox, H. (1997). Frontal behavioral inventory: Diagnostic criteria for frontal lobe dementia. Canadian Journal of Neurological Sciences, 24, 29–36.Google Scholar
Kertesz, A., Davidson, W., McCabe, P., Takagi, K., & Munoz, D. (2003). Primary progressive aphasia: Diagnosis, varieties, evolution. Journal of the International Neuropsychological Society, 9, 710–719.Google Scholar
Kertesz, A., Hudson, L., Mackenzie, I.R., & Munoz, D.G. (1994). The pathology and nosology of primary progressive aphasia. Neurology, 44, 2065–2072.Google Scholar
Kertesz, A., Martinez-Lage, P., Davidson, W., & Munoz, D.G. (2000). The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia. Neurology, 55, 1368–1375.Google Scholar
Kertesz, A., McMonagle, P., Blair, M., Davidson, W., & Munoz, D.G. (2005). The evolution and pathology of frontotemporal dementia. Brain, 128, 1996–2005.Google Scholar
Kertesz, A. & Munoz, D.G. (2003). Primary progressive aphasia and Pick complex. Journal of the Neurological Sciences, 206, 97–107.Google Scholar
Kertesz, A. & Munoz, D. (2004). Relationship between frontotemporal dementia and corticobasal degeneration/progressive supranuclear palsy. Dementia and Geriatric Cognitive Disorders, 17, 282–286.Google Scholar
Kertesz, A. & Poole, E. (1974). The aphasia quotient: The taxonomic approach to measurement of aphasic disability. Canadian Journal of Neurological Sciences, 1, 7–16.Google Scholar
Kucera, H. & Francis, W.N. (1967). Computational analysis of present-day American English. Providence, RI: Brown University Press.
Marczinski, C.A., Davidson, W., & Kertesz, A. (2004). A longitudinal study of behavior in frontotemporal dementia and primary progressive aphasia. Cognitive and Behavioral Neurology, 17, 185–190.Google Scholar
Marczinski, C.A. & Kertesz, A. (2006). Category and letter fluency in semantic dementia, primary progressive aphasia, and Alzheimer's disease. Brain and Language, 97, 258–265.Google Scholar
Mattis, S. (1988). Dementia Rating Scale (DRS). Odessa, Fl: Psychological Assessment Resources.
McKhann, G.M., Albert, M.S., Grossman, M., Miller, B., Dickson, D., & Trojanowski, J.Q. (2001). Clinical and pathological diagnosis of frontotemporal dementia: Report of the Work Group on Frontotemporal Dementia and Pick's Disease. Archives of Neurology, 58, 1803–1809.Google Scholar
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E.M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939–944.Google Scholar
Mesulam, M.M. (1982). Slowly progressive aphasia without generalized dementia. Annals of Neurology, 11, 592–598.Google Scholar
Mesulam, M.M. (1987). Primary progressive aphasia—Differentiation from Alzheimer's disease. Annals of Neurology, 22, 533–534.Google Scholar
Mesulam, M.M. (2001). Primary progressive aphasia. Annals of Neurology, 49, 425–432.Google Scholar
Mesulam, M.M. (2003). Primary progressive aphasia—A language-based dementia. New England Journal of Medicine, 349, 1535–1542.Google Scholar
Murdoch, B.E., Chenery, H.J., Wilks, V., & Boyle, R.S. (1987). Language disorders in dementia of the Alzheimer type. Brain and Language, 31, 122–137.Google Scholar
Neary, D. (1990). Dementia of frontal lobe type. Journal of the American Geriatric Society, 38, 71–72.Google Scholar
Neary, D., Snowden, J.S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P.H., Albert, M., Boone, K., Miller, B.L., Cummings, J., & Benson, D.F. (1998). Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology, 51, 1546–1554.Google Scholar
Pick, A. (1892). Uber die Beziehungen der senilen Hirnatrophie zur Aphasie. Prager Medizinische Wochenschrift, 17, 165–167.Google Scholar
Raven, J.C. (1965). Guide to using the coloured progressive matrices. London: H.K. Lewis.
Snowden, J.S., Goulding, P.J., & Neary, D. (1989). Semantic dementia: A form of circumscribed cerebral atrophy. Behavioral Neurology, 2, 167–182.Google Scholar
Warrington, E.K. (1975). The selective impairment of semantic memory. Quarterly Journal of Experimental Psychology, 27, 635–657.Google Scholar
Weintraub, S., Rubin, N.P., & Mesulam, M.M. (1990). Primary progressive aphasia: Longitudinal course, neuropsychological profile, and language features. Archives of Neurology, 47, 1329–1335.Google Scholar
Zakzanis, K.K. (1999). The neuropsychological signature of primary progressive aphasia. Brain and Language, 70, 70–85.Google Scholar