Frames have been defined as a certain type of generalization of Room square. Frames have proven useful in the construction of Room squares, in particular, skew Room squares.
We generalize the definition of frame and consider the construction of Room squares and skew Room squares using these more general frames.
We are able to construct skew Room squares of three previously unknown sides, namely 93, 159, and 237. This reduces the number of unknown sides to four: 69, 87, 95 and 123. Also, using this construction, we are able to give a short proof of the existence of all skew Room squares of (odd) sides exceeding 123.
Finally, this frame construction is useful for constructing Room squares with subsquares. We can also construct Room squares “missing” subsquares of sides 3 and 5. The “missing” subsquares of sides 3 and 5 do not exist, so these incomplete Room squares cannot be completed to Room squares.