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Smokers’ Treatment Expectancies Predict Smoking Cessation Success

Published online by Cambridge University Press:  27 August 2014

Lisa M. Fucito ,
Benjamin A. Toll ,
Corey R. Roos  and
Andrea C. King
Lisa M. Fucito*
Affiliation:
Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA
Benjamin A. Toll
Affiliation:
Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA Yale Cancer Center, New Haven, CT, USA Yale-New Haven Hospital, New Haven, CT, USA
Corey R. Roos
Affiliation:
Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA Department of Psychology, University of New Mexico, Albuquerque, NM, USA
Andrea C. King
Affiliation:
Department of Psychiatry & Behavioral Neuroscience, University of Chicago, Chicago, IL, USA
*
Address for correspondence: Lisa M. Fucito, Department of Psychiatry, Yale University School of Medicine, 1 Long Wharf Drive, Box 18, New Haven, CT 06511, USA. Email: [email protected]
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Abstract

Introduction: Smokers’ treatment expectancies may influence their choice of a particular medication as well as their medication experience.

Aims: This study examined the role of smokers’ treatment expectancies to their smoking cessation outcomes in a completed, randomized, placebo-controlled trial of naltrexone for smoking cessation, controlling for perceptions of treatment assignment.

Methods: Treatment-seeking cigarette smokers (N = 315) were randomized to receive either naltrexone (50 mg) or placebo in combination with nicotine patch and behavioural counselling. Expectancies for naltrexone as a smoking cessation aid were assessed at baseline and four weeks after the quit date.

Results: More positive baseline medication expectancies predicted higher quit rates at one month in the naltrexone group (OR = 1.45, p = 0.04) but were associated with lower quit rates in the placebo group (OR = 0.66, p = 0.03). Maintaining and/or increasing positive medication expectancies in the first month of treatment was associated with better pill adherence during this interval in the naltrexone group (ps < 0.05). Positive baseline medication expectancies were also associated with the perception of having received naltrexone over placebo among all participants.

Conclusions: Positive medication expectancies in smokers may contribute to better treatment response. Assessing treatment expectancies and attempting to maintain or improve them may be important for the delivery, evaluation, and targeting of smoking cessation treatments.

Type
Original Articles
Information
Journal of Smoking Cessation , Volume 11 , Issue 3 , September 2016 , pp. 143 - 149
Copyright
Copyright © The Author(s), published by Cambridge University Press on behalf of Australian Academic Press Pty Ltd 2014 

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