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Hypofractioned radiotherapy versus conventional radiotherapy for the treatment of multiform glioblastoma in adults over 70 years old

Published online by Cambridge University Press:  18 July 2019

Adriana Jiménez Cantero ,
Jessica Chávez Nogueda ,
Fabiola Flores Vázquez ,
José Pablo Castillo de la Garza ,
Raymundo Hernández Montes de Oca  and
Alejandro Olmos Guzmán Open the ORCID record for Alejandro Olmos Guzmán [Opens in a new window]
Adriana Jiménez Cantero
Affiliation:
National Hospital XXI Century, Radiation Oncology Service, Instituto Mexicano del Seguro Social, Ciudad de México, México
Jessica Chávez Nogueda
Affiliation:
National Hospital XXI Century, Radiation Oncology Service, Instituto Mexicano del Seguro Social, Ciudad de México, México
Fabiola Flores Vázquez
Affiliation:
National Hospital XXI Century, Radiation Oncology Service, Instituto Mexicano del Seguro Social, Ciudad de México, México
José Pablo Castillo de la Garza
Affiliation:
National Hospital XXI Century, Radiation Oncology Service, Instituto Mexicano del Seguro Social, Ciudad de México, México
Raymundo Hernández Montes de Oca
Affiliation:
National Hospital XXI Century, Radiation Oncology Service, Instituto Mexicano del Seguro Social, Ciudad de México, México
Alejandro Olmos Guzmán
Affiliation:
National Hospital XXI Century, Radiation Oncology Service, Instituto Mexicano del Seguro Social, Ciudad de México, México
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Abstract

Aim:

Multiform glioblastoma (MG) represents 70% of all gliomas, with half of patients older than 65 years with median survival of 12–18 months, hypofractionation seeks to reduce the intensity and duration of treatment without impacting on survival rates. The objective was to determine the global survival and recurrence-free survival of adults over 70 years old with MG treated with hypofractionated radiotherapy and standard scheme. The review of patients older than 70 years treated with radiotherapy from 2013 to 2016 was performed.

Results:

Twenty-four patients were analysed, with a median follow-up of 239 days, and there is no difference in overall survival 12·3 versus 10·5 months (p = 0·55) and recurrence-free survival 8·3 versus 3·4 months (p = 0·48) between both schemes, conventional versus hypofractioanted, respectively.

Conclusion:

The results in this study show that hypofractionated scheme could be comparable in overall survival and recurrence-free survival to conventional fractionation, but a longer patients’ trial should be done.

Keywords

conventional radiotherapyglioblastoma multiformglioblastoma multiform elderlyhypofractionated radiotherapy
Type
Technical Note
Information
Journal of Radiotherapy in Practice , Volume 19 , Issue 2 , June 2020 , pp. 193 - 196
Copyright
© Cambridge University Press 2019

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