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Tissue Levels of Chlorpromazine in Experimental Animals

Published online by Cambridge University Press:  08 February 2018

Magdalena Berger Wechsler  and
Leon Roizin
Magdalena Berger Wechsler
Affiliation:
Department of Experimental Psychiatry, New York State Psychiatric Institute, New York, N.Y., and Department of Biochemistry, College of Physicians and Surgeons, Columbia University
Leon Roizin
Affiliation:
Department of Neuropathology, New York State Psychiatric Institute, New York, N.Y., and Department of Pathology, College of Physicians and Surgeons, Columbia University
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Extract

The increasing use of tranquillizers in the treatment of mental disorders has made it imperative to study both the immediate and long-term effects of these drugs in order to establish their limits of safety. One of the approaches that appeared important to us was the correlation of the histological findings (Roizin, True and Knight, 1959) with tissue levels of the drug. In addition to its significance from the pathological standpoint, such a study may also furnish information towards a better understanding of the mechanism of action of these drugs.

Type
Original Articles
Information
Journal of Mental Science , Volume 106 , Issue 445 , October 1960 , pp. 1501 - 1505
Copyright
Copyright © Royal College of Psychiatrists, 1960 

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References

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