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Comparison of Two Anti-Depressant Drugs (Imipramine and Pheniprazine) In Endogenous Depressive Illnesses in Female In-Patients

Published online by Cambridge University Press:  08 February 2018

Donald P. Oakley
Donald P. Oakley*
Affiliation:
Whittingham Hospital, Preston. (Now Assistant Psychiatrist, York Mental Health Service.)
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Extract

The following study was designed to compare the effectiveness of imipramine (Tofranil) and pheniprazine (Cavodil) in the treatment of endogenous depression. Controlled trials have shown the value of imipramine (Holdway, 1960) and therefore no placebo group was included. The theoretical advantages of a cross-over technique were considered to be outweighed by such disadvantages as the tendency for the effects of the first therapeutic agent to continue into the second phase of the experiment; and the tendency for rapid remissions to occur with anti-depressive drugs and to persist for a period despite withdrawal. Thus two similar groups of patients, each treated with full dosage of their respective drugs, were compared. The selection of patients was randomized, and the trial was blind throughout.

Type
Original Articles
Information
Journal of Mental Science , Volume 107 , Issue 451 , November 1961 , pp. 1000 - 1002
Copyright
Copyright © Royal College of Psychiatrists, 1961 

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References

Crisp, A. H., Hays, P., and Carter, A., Lancet, 1961, i, 17.Google Scholar
Holdway, V., J. Ment. Sci., 1960, 106, 1443.CrossRefGoogle Scholar
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