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The Role of Nicotinic Acid (Niacin) in Mental Health and Disease

Published online by Cambridge University Press:  08 February 2018

Ian Gregory
Ian Gregory*
Affiliation:
The Ontario Hospital, London, Ontario, Canada
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Extract

Shortly before the end of the last century, Eijkman observed that fowl receiving a diet of polished rice developed a disease which he believed to be of the same nature as human beri-beri. It was subsequently shown that this condition in fowl (polyneuritis gallinarum), and beri-beri in man, could both be cured by the addition to the diet of rice polishings or an extract prepared from them. In 1911, Funk obtained from rice polishings a crystalline substance capable of preventing or curing beri-beri, which he named “vitamine” in view of its evident importance to life, and in the erroneous belief that it had the chemical structure of an amine. Four years later, McCollum and Davis demonstrated that at least two such dietary factors were necessary for growth in rats—“fat-soluble A” and “water-soluble B”. Before long it was recognized that the latter factor had the properties of the antineuritic “vitamine“, and a number of similar organic compounds were discovered, which were essential constituents of the diet in minute quantities, and for which the general term “vitamin”, was agreed upon. For several years it was assumed that water-soluble vitamin B (contained in yeast, rice polish, liver, etc.) was a single entity, but in 1919 Mitchell noted that certain vegetables rich in the antineuritic principle had little power to promote growth, and in 1926 two fractions were distinguished, each essential for growth—thermolabile vitamin B1, containing the antineuritic principle (thiamin), and thermostable vitamin B2.

Type
Original Articles
Information
Journal of Mental Science , Volume 101 , Issue 422 , January 1955 , pp. 85 - 109
Copyright
Copyright © Royal College of Psychiatrists, 1955 

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References

1. GOLDBERGER, J., U.S.A. Pub. Hlth. Rep. No. 1174, 1927.Google Scholar
2. Funk, C. J., Physiologist, 1911, 43, 395.Google Scholar
3. Warburg, O., Science, 1925, 61, 575.Google Scholar
4. Elvehjem, C. A., Madden, R. J., Strong, F. M., and Woolley, D. W., J. Biol. Chem., 1938, 123, 137.CrossRefGoogle Scholar
5. Fours, P. J., Helmer, O. M., Leplovsky, S., and Jukes, T. H., Proc. Soc. Exper. Biol. and Med., 1937, 37, 405.Google Scholar
6. Smith, D. T., Ruffin, J. M., and Smith, S. G., J.A.M.A., 1937, 109, 2054.Google Scholar
7. Spies, T. D., Cooper, C., and Blankenhorn, M. A., J.A.M.A., 1938, 110, 622.Google Scholar
8. Spies, T. D., Aring, C. D., Gelperin, J., and Bean, W. B., Amer. J. Med. Sci., 1938, 196, 461.Google Scholar
9. Jolliffe, N., J. Mt. Sinai Hosp., 1942, 8, 658.Google Scholar
10. Spies, T. D., and Butt, H. R., Diseases of Metabolism, 1952, pp. 488–501. Edited by Duncan, G. G. 3rd Edition. Philadelphia: W. B. Saunders Company.Google Scholar
11. Darby, W. J., Principles of Internal Medicine, 1950, pp. 522–6. Edited by Harrison, T. R., et al. Philadelphia: Blakiston Company.Google Scholar
12. Youmans, J. B., Handbook of Nutrition, 1951, pp. 554–62. 2nd Edition, A.M.A. Philadelphia: Blakiston Company.Google Scholar
13. Lettner, Z. A., Brit. med. J., 1948, 1, 917.Google Scholar
14. Keys, A., Diseases of Metabolism, 1952, pp. 574–6. Edited by Duncan, G. G. 3rd Edition. Philadelphia: W. B. Saunders Company.Google Scholar
15. McLester, J. S., Nutrition and Diet in Health and Disease, 1949, pp. 77–8 and 318–24. 5th Edition. Philadelphia: W. B. Saunders Company.Google Scholar
16. Najjar, V. A., and Holt, L. E., J.A.M.A., 1943, 123, 683.Google Scholar
17. Najjar, V. A., Johns, G. A., Medairy, G. C., Fleischmann, G., and Holt, L. E., J.A.M.A., 1944, 126, 357.CrossRefGoogle Scholar
18. Ellinoer, P., Coulson, R. A., and Benesch, R., Nature, 1944, 154, 270.CrossRefGoogle Scholar
19. Ellinger, P., Benesch, R., and Kay, W. W., Lancet, 1945, ii, 432.Google Scholar
20. Best, C. H., and Taylor, N. B., Physiological Basis of Medical Practice, 1950, pp. 738, and 742–4. 5th Edition. Baltimore: Williams & Wilkins Company.Google Scholar
21. Krehl, W. A., Tepley, L. H., and Elvehjem, C. A., Proc. Soc. Exper. Biol. and Med., 1945, 58, 334.Google Scholar
22. Krehl, W. A., Sarma, P. S., and Elvehjem, C. A., J. Biol. Chem., 1946, 162, 403.Google Scholar
23. Krehl, W. A., Sarma, P. S., Tepley, L. H., and Elvehjem, C. A., J. Nutr., 1946, 31, 85.Google Scholar
24. Krehl, W. A., Huerga, J. de la, and Elvehjem, C. A., J. Biol. Chem., 1946, 164, 551.Google Scholar
25. Ackroyd, W. R., and Swammathan, M., Ind. J. Med. R., 1940, 27, 667.Google Scholar
26. Briggs, G. M., J. Biol. Chem., 1945, 161, 749.CrossRefGoogle Scholar
27. Niven, C. F., Washburn, M. R., and Sperling, G. A., Proc. Soc. Exper. Biol. and Med., 1946, 63, 106.CrossRefGoogle Scholar
28. Raska, S. B., Science, 1947, 105, 126.Google Scholar
29. Joffe, P. N., and Jolliffe, N., Amer. J. Med. Sci., 1937, 193, 501.Google Scholar
30. Jones, W. A., and Jones, G. P., Lancet, 1953, i, 1073.CrossRefGoogle Scholar
31. Spies, T. D., Clinical Nutrition, 1950, pp. 531–41. Edited by Jolliffe, N., Tisdall, F. F., and Cannon, P. R. New York: Paul B. Hoeber, Inc. Google Scholar
32. Idem , Textbook of Medicine, 1951, pp. 575–81. Edited by Cecil, R. L., and Loeb, R. F. 8th Edition. Philadelphia: W. B. Saunders Company.Google Scholar
33. Mann, G. V., and Stare, F. J., Handbook of Nutrition, 1951, pp. 351–82. 2nd Edition. A.M.A. Philadelphia: Blakiston Company.Google Scholar
34. Hardwick, S. W., J. Ment. Sci., 1946, 92, 310.Google Scholar
35. Weiss, E., and English, O. S., Psychosomatic Medicine, 1949, pp. 4–5. 2nd Edition. Philadelphia: W. B. Saunders Company.Google Scholar
36. Redlich, F. C., Hillingshead, A. B., Roberts, B. H., Robinson, H. A., Freedman, L. Z., and Myers, J. K., Amer. J. Psychiat., 1953, 109, 729–33.Google Scholar
37. Klauder, J. V., and Winkelmann, N. W., J.A.M.A., 1928, 90, 364–71.Google Scholar
38. Boggs, T. R., and Padget, P., Bull. Johns Hopkins Hosp., 1932, 50, 21.Google Scholar
39. Leigh, D., J. Ment. Sci., 1952, 98, 130.Google Scholar
40. Henderson, D., and Gillespie, R. D., Textbook of Psychiatry, 1950, p. 440. 7th Edition. London: Oxford University Press.Google Scholar
41. Strecker, E. A., Ebaugh, F. G., and Ewalt, J. R., Practical Clinical Psychiatry, 1951, pp. 72, 84, and 144. 7th Edition. Philadelphia: Blakiston Company.Google Scholar
42. McLester, J. S., J.A.M.A., 1939, 112, 2110.Google Scholar
43. Sydenstricker, V. P., Arch. Int. Med., 1941, 67, 746.Google Scholar
44. Spies, T. D., Bean, W. B., and Stone, R. E., J.A.M.A., 1938, 111, 584.Google Scholar
45. Wilkinson, P. B., Lancet, 1944, ii, 655.Google Scholar
46. Fairley, N. H., Textbook of the Practice of Medicine, 1950, pp. 530–4. Edited by Price, F. W. 8th Edition. London: Oxford University Press.Google Scholar
47. Jolliffe, N., Goodhart, R., Gennis, J., and Cline, J. K., Amer. J. Med. Sci., 1939, 198, 198.Google Scholar
48. Williams, R. D., Mason, H. L., and Smith, B. F., Proc. Staff. Meet., Mayo Clin., 1939, 14, 787.Google Scholar
49. Williams, R. D., Mason, H. L., Wilder, R. M., and Smith, B. F., Arch. Int. Med., 1940, 66, 785.CrossRefGoogle Scholar
50. Williams, R. D., Mason, H. L., Smith, B. F., and Wilder, R. M., Ibid., 1942, 69, 721.Google Scholar
51. Williams, R. D., Mason, H. L., Power, M. H., and Wilder, R. M., Ibid., 1943, 71, 38.Google Scholar
52. Johnson, R. E., Darling, R. C., Forbes, H. W., Brouha, L., Egana, E., and Graybeil, A., J. Nutr., 1942, 24, 585.Google Scholar
53. Barborka, C. J., Foltz, E. E., and Ivy, A. C., J.A.M.A., 1943, 122, 717.Google Scholar
54. Wilder, R. M., Biology of Mental Health and Disease, 1952, pp. 531–7. New York: Pau IB. Hoeber, Inc.Google Scholar
55. Henderson, D., and Gillespie, R. D., Text-book of Psychiatry, 1950, pp. 526–7. 7th Edition. London: Oxford University Press.Google Scholar
56. Strecker, E. A., Ebaugh, F. G., and Ewalt, J. R., Practical Clinical Psychiatry, 1951, pp. 196–8. 7th Edition. Philadelphia: Blakiston Company.Google Scholar
57. Singer, H. D., Arch. Int. Med., 1915, 15, 121–46.Google Scholar
58. Spies, T. D., Walker, A. A., and Woods, A. W., J.A.M.A., 1939, 113, 1481–3.Google Scholar
59. Gillman, T., and Gillman, J., Arch. Int. Med., 1945, 76, 63.Google Scholar
60. Paterson, D., and Moncrieff, A., Diseases of Children, 1949, 2, 122. 4th Edition. London: Edward Arnold and Co.Google Scholar
61. Ford, F. R., Diseases of the Nervous System in Infancy, Childhood and Adolescence, 1952, p. 769. 3rd Edition. Springfield, Illinois: Charles C. Thomas.Google Scholar
62. Carothers, J. C., The African Mind in Health and Disease, 1953, p. 121. Geneva: World Health Organization.Google Scholar
63. Matthews, R. S., J.A.M.A., 1938, 111, 1148.Google Scholar
64. Sydenstricker, V. P., Schmidt, H. L. Jr., Fulton, M. C., New, J. S., and Geeslin, L. E., South. Med. J., 1938, 31, 1155.Google Scholar
65. Aring, C. D., and Spies, T. D., J. Neurol. and Psychiat., 1939, 2, 335.Google Scholar
66. Hardwick, S. W., Lancet, 1943, ii, 43.Google Scholar
67. Cleckley, H. M., Sydenstricker, V. P., and Geeslin, L. E., J.A.M.A., 1939, 112, 2107.Google Scholar
68. Sydenstricker, V. P., and Cleckley, H. M., Amer. J. Psychiat., 1941, 98, 83.Google Scholar
69. Gottlieb, B., Brit. med. J., 1944, i, 392.Google Scholar
70. Musselman, M. M., War Med., 1945, 8, 325.Google Scholar
71. Foster, T. L., J. Nerv. and Ment. Dis., 1949, 110, 1.Google Scholar
72. Dewan, J. G., Amer. J. Psychiat., 1943, 99, 565.Google Scholar
73. Sydenstricker, V. P., Proc. Roy. Soc. Med., 1943, 36, 169.Google Scholar
74. Henderson, D., and Gillespie, R. D., Text-book of Psychiatry, 1950. pp. 462–3. 7th Edition. London: Oxford University Press.Google Scholar
75. JOLUFFE, N., A. Research Nerv. and Ment. Dis. Proc., 1938, 1939, 19, 144.Google Scholar
76. Jolliffe, N., Bowman, K. M., Rosenblum, L. A., and Fein, H. D., J.A.M.A., 1940, 114, 307.Google Scholar
77. Joluffe, N., Wortis, H., and Fein, H. D., Arch. Neurol. and Psychiat., 1941, 46, 569.Google Scholar
78. Wortis, H., Bueding, E., Stein, M. H., and Jolliffe, N., Arch. Neurol. and Psychiat., 1942, 47, 215.Google Scholar
79. Bender, L., and Schilder, P., Arch. Neurol. and Psychiat., 1930, 29, 990.Google Scholar
80. Bowman, K. M., and Wortis, H., A. Research Nerv. and Ment. Dis. Proc., 1941, 1943, 22, 168.Google Scholar
81. Spillane, J. D., Nutritional Disorders of the Nervous System, 1947, pp. 29–45, 82–102, and 178–9. Edinburgh: E. & S. Livingstone Ltd.Google Scholar
82. Hardwick, S. W., “Recent Progress in Psychiatry”, Volume 2. Edited by Fleming, G. W. T. H. J. Ment. Sci., 1950, pp. 111–131.Google Scholar
83. Lehmann, H., Biology of Mental Health and Disease, 1952, pp. 582–8. New York: Paul B. Hoeber, Inc.Google Scholar
84. Wernicke, C., Lehrbuch der Gehirnkrankheiten für Aertze und Studierende, 1882, 2, 229. Berlin: T. Fischer.Google Scholar
85. Alexander, L., Myerson, A., and Puoan, M., J. Am. Neurol. A., 1938, 64, 135.Google Scholar
86. Alexander, L., Am. J. Path., 1940, 16, 61.Google Scholar
87. Campbell, A. C. P., and Biggart, J. H., J. Path, and Bact., 1939, 48, 245.Google Scholar
88. Meyer, A., J. Neurol. Neurosurg. and Psychiat., 1944, 7, 66.Google Scholar
89. Wexbero, E., Am. J. Psychiat., 1941, 97, 1406.Google Scholar
90. Idem , Mental Health in Later Maturity, 1943, pp. 53–8. United States Public Health Service. Supplement No. 168.Google Scholar
91. Stephenson, W., Penton, C., and KorenchevskY, V., Brit. med. J., 1941, ii, 839.Google Scholar
92. Meyersburg, H. A., New England J. Med., 1945, 233, 173.Google Scholar
93. Shock, N. W., Mental Disorders in Later Life, 1945, pp. 23–53. Edited by Kaplan, O. J. Stanford, California: Stanford University Press.Google Scholar
94. Sebrell, W. H., Geriatric Medicine, 1949, p. 191. Edited by Stieglitz, E. J. 2nd Edition. Philadelphia: W. B. Saunders Company.Google Scholar
95. Caldwell, W. A., and Hardwick, S. W., J. Ment. Sci., 1944, 90, 95.Google Scholar
96. Strecker, E. A., Ebaugh, F. G., and Ewalt, J. R., Practical Clinical Psychiatry, 1951, p. 113. 7th Edition, Philadelphia: Blakiston Company.Google Scholar
97. Moore, D. F., Morris, C. W., Smith, F. V. Jr., and Lawson, J. L., J. Clin. and Exper. Psychopath., 1951, 12, 249.Google Scholar
98. Gregory, I., Am. J. Psychiat., 1952, 108, 888.Google Scholar
99. Levy, S., J.A.M.A., 1953, 153, 1260.Google Scholar
100. Government of Canada (Dominion Bureau of Statistics), Mental Institutions, 1952, 21st Annual Report, 1954, p. 26. Ottawa: Edmond Cloutier.Google Scholar
101. Lehmann, H., Canad. M. A. J., 1944, 51, 558.Google Scholar
102. Idem , Ibid., 1949, 60, 157.Google Scholar
103. Kalinowsky, L. B., and Hoch, P. H., Shock Treatments, Psychosurgery and Other Somatic Treatments in Psychiatry, 1952, p. 48. 2nd Edition. New York: Grune & Stratton.Google Scholar
104. Washburne, A. C., Ann. of Int. Med., 1950, 32, 261.Google Scholar
105. Thompson, L. J., and Proctor, R. C., North Carolina M. J., 1953, 14, 420.Google Scholar
106. Best, C. H., and Taylor, N. B., Physiological Basis of Medical Practice, 1950, pp. 916–20. 5th Edition. Baltimore: Williams & Wilkins Company.Google Scholar
107. Elliott, K. A. C., Scott, D. B. M., and Libet, B., J. Biol. Chem., 1942, 146, 251.Google Scholar
108. von Euler, H., Hebers, H., and Schlenck, F., Z. Physiol. Chem., 1935, 237, 1.Google Scholar
109. Warburg, O., and Christian, W., Biochem. Z., 1936, 285, 156.Google Scholar
110. Grollman, A., and Slaughter, D., Cushny's Pharmacology and Therapeutics, 1947, pp. 595–7. 13th Edition. Philadelphia: Lea and Febiger.Google Scholar
111. Sevag, M. G., Gots, J. S., and Steers, E., The Enzymes, 1950, p. 153. Edited by J. B. Sumner and K. Myrbäck. New York: Academic Press Inc.Google Scholar
112. Elvehjem, C. A., Physiol. Rev., 1940, 20, 249.Google Scholar
113. McFarland, R. A., Biology of Mental Health and Disease, 1952, pp. 335–55. New York: Paul B. Hoeber, Inc.Google Scholar
114. Lovett Doust, J. W., and Schneider, R. A., J. Ment. Sci., 1952, 98, 411.Google Scholar
115. Morell, T., Deut. Med. Wchnschr., 1940, 66, 398.CrossRefGoogle Scholar
116. Frankau, I. M., Brit. med. J., 1943, ii, 601.Google Scholar
117. Calder, R. M., Proc. Soc. Exper. Biol. and Med., 1948, 68, 642.Google Scholar
118. Abramson, D. I., Katzenstein, K. H., and Senior, F. A., Amer. J. Med. Sc., 1940, 200, 96.Google Scholar
119. Moore, M. T., Arch. Int. Med., 1940, 65, 1.Google Scholar
120. Aring, C. D., Ryder, H. W., Roseman, E., Rosenbaum, M., and Ferris, E. B., Arch. Neurol. and Psychiat., 1941, 46, 649.Google Scholar
121. Loman, J., Rinkel, M., and Myerson, A., Amer. J. Med. Sc., 1941, 202, 211.Google Scholar
122. Scheinberg, P., Circulation, 1950, 1, 1148.Google Scholar
123. Furtado, D., Moutinho, H., Chichorro, V., and Ferreira, M., Arch. F. Neurol. Psychiat., 1949, 64, 83.Google Scholar
124. Freyhan, F. A., Woodward, R. B., and Kety, S. S., J. Nerv. and Ment. Dis., 1951, 113, 511.Google Scholar
125. Sebrell, W. H., The Canad. Hospital, 1953, 30, 39.Google Scholar
126. Wilder, R. M., Biology of Mental Health and Disease, 1952, p. 536. New York: Paul B. Hoeber, Inc.Google Scholar
127. Dunlop, D. M., Davidson, L. S. P., and McNee, J. W., Textbook of Medical Treatment, 1949, pp. 401–3. 5th Edition. Edinburgh: E. & S. Livingstone Ltd.Google Scholar
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