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Engineered 2D nanomaterials–protein interfaces for efficient sensors

Published online by Cambridge University Press:  20 November 2015

Kiran Kumar Tadi ,
Tharangattu N. Narayanan ,
Sivaram Arepalli ,
Kaustav Banerjee ,
Sowmya Viswanathan ,
Dorian Liepmann ,
Pulickel M. Ajayan  and
Venkatesan Renugopalakrishnan
Kiran Kumar Tadi
Affiliation:
TIFR-Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research, Hyderabad – 500 075 Telangana, India
Tharangattu N. Narayanan*
Affiliation:
TIFR-Centre for Interdisciplinary Sciences, Tata Institute of Fundamental Research, Hyderabad – 500 075 Telangana, India
Sivaram Arepalli
Affiliation:
Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77251-1892, USA
Kaustav Banerjee
Affiliation:
Department of Electrical and Computer Engineering, University of California, Santa Barbara, California 93106-9560, USA
Sowmya Viswanathan
Affiliation:
Newton Wellesley Hospital, Newton, Massachusetts 02462, USA
Dorian Liepmann
Affiliation:
Department of Bioengineering, University of California, Berkeley, California 94720-1762, USA
Pulickel M. Ajayan
Affiliation:
Department of Materials Science and Nanoengineering, Rice University, Houston, Texas 77005-1892, USA
Venkatesan Renugopalakrishnan*
Affiliation:
Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; and Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, USA
*
a)Address all correspondence to these authors. e-mail: [email protected] or [email protected]
b)e-mail: [email protected]
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Abstract

This article features the importance of nanomaterial–protein interfaces, with a special interest on two-dimensional (2D) nanomaterials, for next generation sensors and electronics. Graphene, the first isolated and studied 2D nanomaterial, is taken as the material of most interest and then focused on its engineering by heteroatom doping. The success of graphene engineering for sensors widened the search for better and efficient biosensor platforms of other layered materials such as boron nitride and transition metal dichalcogenides. But functionalization of 2D backbones with biomolecules often ends up with the disruption of the biological activities due to various reasons. This has to be fundamentally studied and corrected for the clinical implementation of these materials based novel sensing platforms in point-of-care devices and micro-fluidic chips. At the end, importance of various 2D materials–biomolecule interfaces is discussed, and MoS2 based label-free biosensor is highlighted. A method for the modification of MoS2–biomolecule interaction via covalent functionalization of oxygen functionalities in MoS2 is also proposed.

Keywords

grapheneMoS2proteininterface2D nanomaterialssensorsFET
Type
Invited Feature Papers
Information
Journal of Materials Research , Volume 30 , Issue 23 , 14 December 2015 , pp. 3565 - 3574
Copyright
Copyright © Materials Research Society 2015 

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