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Microwave-assisted solution combustion synthesis of high aspect ratio calcium phosphate nanoparticles

Published online by Cambridge University Press:  13 November 2013

Darcy E. Wagner ,
Joseph Lawrence  and
Sarit B. Bhaduri
Darcy E. Wagner*
Affiliation:
Department of Biomedical Engineering, Colleges of Engineering and Medicine, University of Toledo, Toledo, Ohio 43606
Joseph Lawrence
Affiliation:
Department of Bioengineering, College of Engineering, University of Toledo, Toledo, Ohio 43606
Sarit B. Bhaduri
Affiliation:
Department of Mechanical, Industrial, and Manufacturing Engineering, College of Engineering, University of Toledo, Toledo, Ohio 43606; and Division of Dentistry, College of Medicine, University of Toledo, Toledo, Ohio 43614
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Calcium phosphates (CaPs) are major chemical constituents of mammalian bone. Their osteoconductivity in vitro and in vivo has encouraged their use in biomaterial applications such as implant materials and drug delivery. High aspect ratio nanoparticles are attractive for many biomedical applications; however, precise control of the phase and morphology is challenging. The impact of fuel-to-oxidant ratio, pH, and cation chemistry on morphology and phase was studied for CaP-based compositions by microwave-assisted solution combustion synthesis (MASCS) in a urea–nitrate (fuel–oxidant) system. An initial calcium to phosphate ratio of 1.5 was used. Highly crystalline hydroxyapatite (HA) and biphasic CaP nanoparticle compositions were produced as confirmed by x-ray diffraction, scanning electron microscopy, and transmission electron microscopy. MASCS was capable of synthesizing high aspect ratio (∼5 to 20) single and biphasic CaP nanoparticles with diameters ranging from 250 to 500 nm and lengths between 2 and 10 μm.

Keywords

microwave heatingcombustion synthesisnanoscale
Type
Articles
Information
Journal of Materials Research , Volume 28 , Issue 22 , 28 November 2013 , pp. 3119 - 3129
Copyright
Copyright © Materials Research Society 2013 

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