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In vivo bone regeneration analysis of trilayer coated 316L stainless steel implant in rabbit model

Published online by Cambridge University Press:  21 May 2018

Priyanka Majee ,
Shampa Dhar ,
P.K. Mitra ,
Lalzawmliana V. ,
Samit Kumar Nandi ,
Piyali Basak  and
Biswanath Kundu
Priyanka Majee
Affiliation:
Department of Metallurgical and Materials Engineering, Jadavpur University, Kolkata 700032, India
Shampa Dhar
Affiliation:
Department of Metallurgical and Materials Engineering, Jadavpur University, Kolkata 700032, India
P.K. Mitra
Affiliation:
Department of Metallurgical and Materials Engineering, Jadavpur University, Kolkata 700032, India
Lalzawmliana V.
Affiliation:
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India
Samit Kumar Nandi*
Affiliation:
Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata 700037, India
Piyali Basak
Affiliation:
School of Bioscience and Engineering, Jadavpur University, Kolkata 700032, India
Biswanath Kundu*
Affiliation:
Bioceramics and Coating Division, CSIR-Central Glass and Ceramic Research Institute, Kolkata 700032, India
*
a)Address all correspondence to these authors. e-mail: [email protected]
b)e-mail: [email protected]
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Abstract

To increase the corrosion prevention of stainless steel implant and fast recovery due to new bone-cell formation at the orthopedic implant site, in the present investigation, a trilayered (with bioceramic interlayer sandwiched between innermost passivated surface and outermost polymer coating) 316L stainless steel (SS) implant was designed and investigated. It was inferred that this new designed implant invokes faster and more bone-cell formation than uncoated commercially available 316L SS implants. Faster bone-cell formation at the coated implant site reduces the initial threat of implant corrosion. The electrochemical corrosion study proved that this model of coated implants is able to prevent corrosion up to 90% better than uncoated commercially available 316L SS. Subsequently, preclinical studies in the rabbit bone defect model (which included histology, radiology, fluorochrome labeling, push-out test, and scanning electron microscopy taken after 45 and 90 days) proved higher rate of new bone tissue formation and better push-out strength between tissue in contact and the coated implant. The toxicological study of vital organs like liver, kidney, and heart also exhibited no abnormality. The outcome of the experimentations indicates suitability of this trilayered 316L SS implant for bone repair and healing.

Keywords

SS 316L implanttrilayered coatingcorrosion testbone healingtoxicityin vitroin vivo
Type
Invited Article
Information
Journal of Materials Research , Volume 33 , Issue 14: Focus Issue: 3D Printing of Biomaterials , 27 July 2018 , pp. 2106 - 2117
Copyright
Copyright © Materials Research Society 2018 

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