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Should adults with isolated serous otitis media be undergoing routine biopsies of the post-nasal space?

Published online by Cambridge University Press:  10 September 2020

H A Cunniffe
Affiliation:
Department of Otolaryngology, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK
A K Gona*
Affiliation:
Department of Otolaryngology, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK
J S Phillips
Affiliation:
Department of Otolaryngology, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich, UK
*
Author for correspondence: Mr Ajay Kumar Gona, Department of Otolaryngology, Norfolk and Norwich University Hospital, Colney Lane, NorwichNR4 7UY, UK E-mail: [email protected] Fax: +44 (0)1603 287288

Abstract

Background

Serous otitis media is a recognised presentation of Eustachian tube dysfunction secondary to post-nasal space pathology. Post-nasal space biopsies are commonly taken in patients with isolated serous otitis media, despite normal nasendoscopy findings, without robust evidence for doing so. This study examined cases of unilateral serous otitis media with effusion in adults. It is the largest known retrospective study to investigate whether post-nasal space biopsies are indicated in non-endemic regions.

Methods

A retrospective analysis was performed of 119 patients who underwent post-nasal space biopsy because of isolated serous otitis media, in a tertiary referral centre, from 2007 to 2017. Endoscopic examination and final histological report findings were reviewed.

Results

Of the 119 patients identified, 6 (5.0 per cent) were found to have abnormal histology. In all six cases, suspicious clinical findings had been noted on nasendoscopic examination prior to biopsy.

Conclusion

Suspicious findings pre-operatively predict sinister pathology. Biopsies are not recommended in cases of adult serous otitis media with normal nasendoscopy findings if no other risk factors exist. A UK-wide retrospective study or prospective study over the next 10 years will help provide the evidence necessary to support this guidance.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited, 2020

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Footnotes

Mr A K Gona takes responsibility for the integrity of the content of the paper

References

Chua, MLK, Wee, JTS, Hui, EP, Chan, ATC. Nasopharyngeal carcinoma. Lancet 2016;387:1012–24CrossRefGoogle ScholarPubMed
Ferlay, J, Soerjomataram, I, Dikshit, R, Eser, S, Mathers, C, Rebelo, M et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:E359–86CrossRefGoogle ScholarPubMed
Chang, ET, Adami, H-O. The enigmatic epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 2006;15:1765–77CrossRefGoogle ScholarPubMed
Suzina, SA, Hamzah, M. Clinical presentation of patients with nasopharyngeal carcinoma. Med J Malaysia 2003;58:539–45Google ScholarPubMed
Dang, PT, Gubbels, SP. Is nasopharyngoscopy necessary in adult-onset otitis media with effusion? Laryngoscope 2013;123:2081–2CrossRefGoogle ScholarPubMed
Gaze, MN, Keay, DG, Smith, IM, Hardcastle, PF. Routine nasopharyngeal biopsy in adult secretory otitis media. Clin Otolaryngol Allied Sci 1992;17:183–4CrossRefGoogle ScholarPubMed
Luxford, WM, Sheehy, JL. Myringotomy and ventilation tubes: a report of 1,568 ears. Laryngoscope 1982;92:1293–7CrossRefGoogle ScholarPubMed
Robinson, PM. Secretory otitis media in the adult. Clin Otolaryngol Allied Sci 1987;12:297302CrossRefGoogle ScholarPubMed
Dempster, JH, Simpson, DC. Nasopharyngeal neoplasms and their association with adult onset otitis media with effusion. Clin Otolaryngol Allied Sci 1988;13:363–5CrossRefGoogle ScholarPubMed
Poole, K, Hood, K, Davis, BD, Monypenny, IJ, Sweetland, H, Webster, DJT et al. Psychological distress associated with waiting for results of diagnostic investigations for breast disease. Breast 1999;8:334–8CrossRefGoogle ScholarPubMed
Waldron, J, Van Hasselt, CA, Wong, KY. Sensitivity of biopsy using local anesthesia in detecting nasopharyngeal carcinoma. Head Neck 1992;14:24–7CrossRefGoogle ScholarPubMed
Hara, HJ. Malignant tumor of the nasopharynx. Review of literature, and observation of 100 cases (1942–1965). J Otolaryngol Soc Aust 1971;3:187–98Google Scholar
Vokes, EE, Liebowitz, DN, Weichselbaum, RR. Nasopharyngeal carcinoma. Lancet 1997;350:1087–91CrossRefGoogle ScholarPubMed
Neel, HB, Taylor, WF. New staging system for nasopharyngeal carcinoma. Long-term outcome. Arch Otolaryngol Head Neck Surg 1989;115:1293–303CrossRefGoogle ScholarPubMed
Sham, JS, Wei, WI, Kwan, WH, Chan, CW, Choi, PH, Choy, D. Fiberoptic endoscopic examination and biopsy in determining the extent of nasopharyngeal carcinoma. Cancer 1989;64:1838–423.0.CO;2-C>CrossRefGoogle ScholarPubMed
Yousem, DM, Grossman, RI. Neuroradiology: The Requisites, 3rd edn. Philadelphia: Elsevier Health Sciences, 2010;458Google Scholar
Lee, WC, Weiner, GM, Campbell, JB. Should nasopharyngeal biopsy be mandatory in adult unilateral glue ear? J Laryngol Otol 1996;110:62–4CrossRefGoogle ScholarPubMed
Shilo, S, Abu-Ghanem, S, Yehuda, M, Weinger, A, Fliss, DM, Abergel, A. Nasopharyngeal biopsy in adults presenting with serous otitis media: cross-sectional study. Head Neck 2018;40:1565–72CrossRefGoogle ScholarPubMed
Glynn, F, Keogh, IJ, Ali, TA, Timon, CI, Donnelly, M. Routine nasopharyngeal biopsy in adults presenting with isolated serous otitis media: is it justified? J Laryngol Otol 2006;120:439–41CrossRefGoogle ScholarPubMed
Sadr, AH, Sanati, KA, Prior, M. Isolated otitis media with effusion in adults: is biopsy of the postnasal space required? Eur Arch Otorhinolaryngol 2009;266:1667–8CrossRefGoogle ScholarPubMed
Sheu, SH, Ho, KY, Kuo, WR, Juan, KH. The probability of diagnosis of nasopharyngeal carcinoma in patients with only adult-onset otitis media with effusion. Kaohsiung J Med Sci 1998;14:706–9Google ScholarPubMed
Ho, KY, Lee, KW, Chai, CY, Kuo, WR, Wang, HM, Chien, CY. Early recognition of nasopharyngeal cancer in adults with only otitis media with effusion. J Otolaryngol Head Neck Surg 2008;37:362–5Google ScholarPubMed