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p16 status and interval neck dissection findings after a ‘clinically complete response’ to chemoradiotherapy in oropharyngeal squamous cell carcinoma

Published online by Cambridge University Press:  19 June 2015

M S Miah*
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
P Spielmann
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
S J White
Affiliation:
Department of Pathology, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
C Kennedy
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
N Kernohan
Affiliation:
Department of Pathology, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
R E Mountain
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
R Cassasola
Affiliation:
Tayside Cancer Centre, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
S Mahendran
Affiliation:
Department of Otorhinolaryngology – Head and Neck Surgery, Ninewells Hospital and University of Dundee Medical School, Scotland, UK
*
Address for correspondence: Mr Mohammed S Miah, Department of Otorhinolaryngology – Head and Neck Surgery, Ninewells Hospital and University of Dundee Medical School, Dundee DD1 9SY, Scotland, UK Fax: (+44) 01382 632816 E-mail: [email protected]

Abstract

Objectives:

To evaluate the histopathological findings from post-treatment neck dissection of p16 positive and negative oropharyngeal carcinoma cases, after completion of chemoradiotherapy, and to question the role of neck dissection after a ‘clinically complete response’ to chemoradiotherapy.

Methods:

Data were collected retrospectively from a cohort of patients treated with curative intent using chemoradiotherapy and post-treatment neck dissection. Primary tumours underwent p16 immunohistochemistry. Neck dissection specimens were examined for viable cancer cells.

Results:

A total of 76 cases were assessed. Viable cancer cells were detected from neck dissection in 29 per cent of p16 negative cases. Locoregional recurrence occurred in 12.9 per cent of p16 negative cases. The association between p16 positivity in the primary tumour and histopathologically negative neck dissection was significant (p < 0.05).

Conclusion:

p16 status appeared to be an independent marker of disease control for the cohort in this study. The data raise questions about the role of post-treatment neck dissection in p16 positive cases with a ‘clinically complete response’ to chemoradiotherapy.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 2015 

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Footnotes

Presented orally at the Scottish Otorhinolaryngological Society summer meeting, 9–10 May 2013, Dunblane, Scotland, UK.

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