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Management of middle-ear effusions in children†

Published online by Cambridge University Press:  29 June 2007

K. B. Hughes
K. B. Hughes*
Affiliation:
Lieutenent Colonel, RAMC.
*
E.N.T. Department, Doncaster Royal Infirmary, Doncaster.
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Summary

A double-blind placebo controlled trial of Mucodyne (carbocisteine, Berk Pharmaceuticals), Actifed (triprolidine HCI and pseudoephedrine HCI, Wellcome) and combined Mucodyne and Actifed in the treatment of middle-ear effusions is reported. The trial was undertaken to assess whether either preparation, alone or in Combination, would reduce the number of children requiring surgical treatment for this condition. No statistical difference between the various groups in avoiding surgical treatment with Mucodyne was associated with a significantly greater number of ears restored to a normal appearance and middle ear function as measured by tympanometry. All patients relapsing after surgery belonged to the groups receiving placebo, Actifed or the combination of Mucodyne and Actifed prior to the operation.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 98 , Issue 7 , July 1984 , pp. 677 - 684
Copyright
Copyright © JLO (1984) Limited 1984

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Footnotes

†

From the British Military Hospital, Munster, Germany.

References

Bauer, F. (1960) Treatment of ‘Glue Ear’ by Intratympanic Injection of Urea. Journalof Laryngology, 82: 717–722.CrossRefGoogle Scholar
Bluestone, C. D. (1978) Eustachian Tube Function and Allergy in Otitis Media Pediatrics Vol. 61:5: 753–760.Google Scholar
Brooks, D. N. (1976) Middle Ear Effusion in Children. Journal of Otolaryngology, 90: 453–458.Google Scholar
Brown, M. J. K., Richards, S. H. and Ambegaokar, A. G. (1978) Grommets and glue ear: a five year follow up of a controlled trial. Journal of the Royal Society of Medicine, 71: 353–356.CrossRefGoogle ScholarPubMed
Cohen, D. and Sade', J. (1972) Hearing in Secretory Otitis Media. Canadian Journal of Otolaryngology, 1: 27–29.Google Scholar
Edwards, G. F., Steel, A. E., Scott, J. K. and Jordan, J. W. (1976) S—carboxymethylcysteine in the Fluidification of Sputum and Treatment of Chronic Airway Obstruction. Chest, 70: 506–513.CrossRefGoogle ScholarPubMed
Fraser, J. G., Meher, Mehta and Fraser, P. M. (1977) The Medical Treatment of Secretory Otitis Media. Journal of Laryngology and Otology, 91: 757–765.CrossRefGoogle ScholarPubMed
Healey, G. B. and Teele, D. W. (1977) The Microbiology of Chronic Middle Ear Effusions in Children. Laryngoscope, 87: 1472–1478.CrossRefGoogle Scholar
Juhn, S. K., Paparella, M., Kim, C. S., Goycoolea, M. V. and Giebink, S. (1977) Pathogenesis of Otitis Media. Annals of Otolaryngology, 86: 481–492.Google Scholar
Khan, J. A., Marcus, P. and Cummings, S. W. (1981) S—carboxymethylcysteine in Otitis Media with Effusion. Journal of Laryngology and Otology, 95: 995–1002.CrossRefGoogle ScholarPubMed
Klein, S. W., Olson, A. L., Perrin, J. et al. (1979) Prevention and Treatment of Serous Otitis Media with an oral antihistamine. Clinical Pediatrics, 19: 342–347.CrossRefGoogle Scholar
Lim, D. J. (1979) Normal and Pathological Mucosa of the Middle ear and Eustachian tube. Clinical Otolaryngology, 4: 213–234.CrossRefGoogle ScholarPubMed
Lord, I. J. and Elcock, H. W. (1972) Brohexine Hydrochloride in Chronic Secretory Otitis Media-a clinical trial. British Journal of Clinical Practice, 25: 276–278.Google Scholar
Marks, N. J., Mills, R. P. and Shaheen, O. H. (1981) A controlled Trial of Cotrimoxazole Therapy in Serous Otitis Media. Journal of Laryngology and Otology, 95: 1003–1010.CrossRefGoogle ScholarPubMed
Mawson, S. R. (1967) Myringotomy, chymotrypsin and Reverse Politzerization for Glue Ears. Journal of Laryngology and Otology, 81: 147–150.CrossRefGoogle ScholarPubMed
McGuiness, R. J. (1977) Carboxymethylcysteine in the Glue Ear Syndrome. British Journal of Clinical Practice, 31: 105–106.Google ScholarPubMed
Olson, A. L., Klein, S. W., Charney, E. et al. (1978) Prevention and Therapy of Serous Otitis Media by Oral Decongestant. A double blind study in Pediatric Practice. Pediatrics, 61: 679–684.CrossRefGoogle ScholarPubMed
Paradise, J. L. (1977) On Tympanostomy Tubes: Rationale. Results. Reservations and Recommendations. Pediatrics, 60: 86–90.CrossRefGoogle ScholarPubMed
Paradise, J. L. (1980) Otitis Media in Infancy and Children Pediatrics. 65: 917–943.Google Scholar
Ramsden, R. T., Moffat, D. A., Gibson, W. P. R. and Jay, M. M. (1977) S—carboxymethylcysteine in the Treatment of Glue Ear, a double blind trial. Journal of Laryngology and Otology, 9: 847–851.CrossRefGoogle Scholar
Sade', J., Eliezer, N., Silberberg, A. and Nevo, A. C. (1970) The role of mucous in transport by cilia. American Review. Respiratory Disease, 102: 48–52.Google Scholar
Sade', J. (1979) Secretory Otitis Media and its Sequelae. Monographs in Clinical Otolaryngology. Churchill Livingstone.Google Scholar
Senturia, B. H. (1976) Classification of Middle Ear Effusions. Annals of Otology, Rhinology and Laryngology, 85 (Suppl. 25: 15–17).CrossRefGoogle Scholar
Shea, J. J. (1971) Auto-inflation treatment of Serous Otitis Media in Children. Journal of Laryngology and Otology, 85: 1254.CrossRefGoogle Scholar
Smyth, G. D. L. (1980) Chronic Ear Disease. Monographs in Clinical Otolaryngology. Churchill Livingstone.Google Scholar
Taylor, P. H. and Dareshani, N. (1975) S—carboxymethylcysteine Syrup in Secretory Otitis Media. The British Journal of Clinical Practice, 29: 177–179.Google ScholarPubMed
Tos, M. and Poulsen, G. (1976) Secretory Otitis Media Results of treatment with grommets. Archives of Otolaryngology, 102: 672–675.CrossRefGoogle ScholarPubMed
Tos, M., Poulsen, G. and Borch, J. (1978) Tympanometry in 2 year old children. Otorhinolarvngology, 40: 77–85.Google ScholarPubMed
Tos, M. and Poulsen, G. (1979) Tympanometry in 2 year old Children. Otorhinolarvngology, 41: 1–10.Google ScholarPubMed
Tos, M. (1980) Spontaneous Improvement of Secretory Otitis and Impedance Screening. Archives of Otolaryngology, 106: 345–349.CrossRefGoogle ScholarPubMed
Wing, L. W. (1978) Bisolvon and Actifed in the Conservative Management of Glue Ear. Medical Journal of Australia, 1: 289–290.CrossRefGoogle ScholarPubMed