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Malignant granular cell tumour of the cervical sympathetic nerve trunk

Published online by Cambridge University Press:  08 March 2006

Masamitsu Hyodo ,
Akiko Sadamoto  and
Shingo Murakami
Masamitsu Hyodo
Affiliation:
Department of Otolaryngology, Ehime University School of Medicine, Nagoya, Japan
Akiko Sadamoto
Affiliation:
Department of Otolaryngology, Ehime University School of Medicine, Nagoya, Japan
Shingo Murakami
Affiliation:
Ehime and Nagoya City University Medical School, Nagoya, Japan
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Abstract

Granular cell tumour is a rare neoplasm that can occur in various sites. This report describes a 48-year-old female with a malignant granular cell tumour originating from the cervical sympathetic nerve trunk, who presented with hyperaesthesia of the left shoulder. The tumour had a maximum diameter of 86 mm and involved adjacent tissues directly.

Histopathologically, it showed considerable variation in the size and shape of nuclei, with occasional mitosis and an abundant granular cytoplasm. Immunohistochemically, the tumour reacted positively for S-100 protein and neuron-specific enolase, indicating its neural origin. Following total local excision of the lesion, the patient has been well without recurrence.

Keywords

Granular Cell TumourSympathetic Nervous SystemImmunochemistry
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 115 , Issue 10 , October 2001 , pp. 833 - 835
Copyright
© Royal Society of Medicine Press Limited 2001

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