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Functional outcome after long-term low-dose trimethoprim/sulfamethoxazole in chronic rhinosinusitis with purulence: a prospective study

Published online by Cambridge University Press:  02 July 2018

G de Bonnecaze ,
B Chaput ,
A Dupret-Bories ,
S Vergez  and
E Serrano
G de Bonnecaze*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, University Hospital Rangueil-Larrey, Toulouse, France
B Chaput
Affiliation:
Plastic and Aesthetic Surgery, University Hospital Rangueil-Larrey, Toulouse, France
A Dupret-Bories
Affiliation:
Department of Surgery, Institut Universitaire du Cancer de Toulouse Oncopôle, France
S Vergez
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, University Hospital Rangueil-Larrey, Toulouse, France Department of Surgery, Institut Universitaire du Cancer de Toulouse Oncopôle, France
E Serrano
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, University Hospital Rangueil-Larrey, Toulouse, France
*
Address for correspondence: Dr Guillaume de Bonnecaze, 24 Chemin de Pouvourville, 31059 Toulouse, France E-mail: [email protected]
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Abstract

Objective

Trimethoprim/sulfamethoxazole has been suggested as a treatment option for chronic rhinosinusitis with purulence. This study aimed to assess the functional and endoscopic outcomes after a three-month course of low-dose trimethoprim/sulfamethoxazole.

Methods

A prospective study was performed, comprising patients referred to a tertiary care medical centre with a diagnosis of chronic rhinosinusitis with purulence. Trimethoprim/sulfamethoxazole was prescribed at 960 mg/day for three months. Sinonasal complaints and endoscopic findings were documented, and bacteriological data were compared.

Results

Fifteen patients were included. Staphylococcus aureus was the most common bacterium cultured (86 per cent). Improvement in nasal function, as measured by the 22-item Sino-Nasal Outcome Test, was highly significant at three months (p < 0.0005). This improvement slightly decreased but remained significant at 6, 9 and 12 months. No side effects were noted. Endoscopic scores revealed similar and concordant improvements.

Conclusion

Long-term low-dose trimethoprim/sulfamethoxazole therapy seems to be a safe option for selected patients. Additional randomised multicentre studies remain necessary.

Keywords

Trimethoprim-SulfamethoxazoleAntibiotherapyRhinosinusitis
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 7 , July 2018 , pp. 600 - 604
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr G de Bonnecaze takes responsibility for the integrity of the content of the paper

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