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Flow cytometric analysis of DNA content in laryngeal cancer

Published online by Cambridge University Press:  29 June 2007

Raphael Feinmesser*
Affiliation:
Toronto, Canada
Jeremy L. Freeman
Affiliation:
Toronto, Canada
Arnold Noyek
Affiliation:
Toronto, Canada
*
Dr Raphael Feinmesser, MD Department of OtolaryngologyHadasah Medical Centre—Ein KaremPOB 12000Jerusalem 91120Israel

Abstract

DNA content was measured by flow-cytometric analysis in 30 paraffin embedded sections from patients with laryngeal squamous cell carcinoma. The morphological characteristics and N staging of the tumours as registered in their clinical charts were correlated with their DNA content. Eighty per cent of the tumours were found to have a predominantly aneuploid distribution of DNA values. There was no correlation between the N stage of the tumour or degree of cell differentiation and DNA content. A multiploid pattern correlates with non-metastatic laryngeal tumours and we suggest that this pattern may be a good indicator for biological activity.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 1990

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