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Flow cytometric analysis of DNA content in laryngeal cancer

Published online by Cambridge University Press:  29 June 2007

Raphael Feinmesser ,
Jeremy L. Freeman  and
Arnold Noyek
Raphael Feinmesser*
Affiliation:
Toronto, Canada
Jeremy L. Freeman
Affiliation:
Toronto, Canada
Arnold Noyek
Affiliation:
Toronto, Canada
*
Dr Raphael Feinmesser, MD Department of OtolaryngologyHadasah Medical Centre—Ein KaremPOB 12000Jerusalem 91120Israel
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Abstract

DNA content was measured by flow-cytometric analysis in 30 paraffin embedded sections from patients with laryngeal squamous cell carcinoma. The morphological characteristics and N staging of the tumours as registered in their clinical charts were correlated with their DNA content. Eighty per cent of the tumours were found to have a predominantly aneuploid distribution of DNA values. There was no correlation between the N stage of the tumour or degree of cell differentiation and DNA content. A multiploid pattern correlates with non-metastatic laryngeal tumours and we suggest that this pattern may be a good indicator for biological activity.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 104 , Issue 6 , June 1990 , pp. 485 - 487
Copyright
Copyright © JLO (1984) Limited 1990

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