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The effects of D and L Isomers of menthol upon nasal sensation of airflow

Published online by Cambridge University Press:  29 June 2007

R. Eccles ,
D. H. Griffiths ,
C. G. Newton  and
N. S. Tolley
R. Eccles*
Affiliation:
(Cardiff)
D. H. Griffiths
Affiliation:
(Cardiff)
C. G. Newton
Affiliation:
(Cardiff)
N. S. Tolley
Affiliation:
(Cardiff)
*
R. Eccles, Senior Lecturer in Physiology, University College Cardiff, University College, P O Box 78, Cardiff CF1 1XL.
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Abstract

Objective and subjective measurements of nasal airflow were made before and after inhalation of Vanilla, D-Menthol and L-Menthol separately. Despite the fact that the menthol isomers were mirror images of one another, only L-Menthol produced the sensation of increased nasal airway patency. No objective change in resistance was found after inhaling either D-Menthol, L-Menthol or the vanilla control. These findings demonstrate that L-Menthol exerts a specific action upon nasal sensory nerve endings, which are responsible for the subjective appreciation of nasal airflow.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 102 , Issue 6 , June 1988 , pp. 506 - 508
Copyright
Copyright © JLO (1984) Limited 1988

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References

Adams, L., Lane, R., Shea, A. S., Cockcroft, A. and Guz, A. (1985) Breathlessness during different forms of ventilatory stimulation: a study of mechanisms in normal subjects and respiratory patients. Clinical Science, 69: 663–672.CrossRefGoogle ScholarPubMed
Aitken, R. C. B. (1964) Time Perception in Pilots, MD Thesis. Glasgow 1964.Google Scholar
Burrows, A., Eccles, R. and Jones, A. S. (1983) The effects of camphor. Eucalyptus and menthol vapour on nasal resistance and nasal sensation. Ada Otolaryngologica, 96: 157–161.CrossRefGoogle Scholar
Davies, A. and Eccles, R. (1985) The effects of nasal airflow and menthol on the nasal electromyographic activity of the anaesthetized cat. British Journal of Pharmacology, p.254.Google Scholar
Eccles, R., Lancashire, B. and Tolley, N. S. (1987a) Experimental studies on nasal secretion of airflow. Ada Otolaryngologica. 103: 303–306.CrossRefGoogle Scholar
Eccles, R., Lancashire, B. and Tolley, N. S. (1987b) The effects of aromatics upon inspirational and expiratory nasal resistane to airflow. Clinical Otolaryngology, 12: 11–14.CrossRefGoogle Scholar
McBride, B. and Whitelaw, W. A. (1981) A physiological stimulus to upper airway receptors in humans. Journal of Applied Physiology, 51(5): 1189–1197.CrossRefGoogle ScholarPubMed
Watson, H. R., Hems, R., Rowsell, D. G. and Spring, D. J. (1978) New Compounds With The Menthol Cooling Effects. Journal Sc. Cosmet. Chem. 29: 185–200.Google Scholar