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Clinicopathological determinants of positron emission tomography computed tomography fluorodeoxyglucose standardised uptake value in head and neck carcinoma

Published online by Cambridge University Press:  21 June 2013

E Ozer ,
B Naiboglu ,
U Karapinar ,
A Agrawal ,
H G Ozer  and
D E Schuller
E Ozer
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
B Naiboglu*
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Haydarpasa Numune Educational Hospital, Istanbul, Turkey
U Karapinar
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Denizli Military Hospital, Turkey
A Agrawal
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
H G Ozer
Affiliation:
Department of Biomedical Informatics, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
D E Schuller
Affiliation:
Department of Otolaryngology-Head and Neck Surgery, Arthur G James Cancer Hospital and Richard J Solove Research Institute, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA
*
Address for correspondence: Dr B Naiboglu, Acıbadem Yaprak Sokak No 39/8, Istanbul, Turkey Fax: 00902163360565 E-mail: [email protected]
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Abstract

Background:

Although positron emission tomography computed tomography has proven diagnostic and staging value in head and neck carcinoma, it does not have optimal sensitivity or specificity. The positron emission tomography computed tomography fluorodeoxyglucose standardised uptake value has been shown to be associated with carcinoma stage. This study evaluated the impact of major clinicopathological factors on the standardised uptake value at the primary site and at neck lymph node metastases.

Subjects and methods:

Two hundred and forty-three oral cavity and laryngopharyngeal carcinoma patients who underwent positron emission tomography computed tomography were included. Correlation between the positron emission tomography computed tomography standardised uptake value and various clinicopathological factors was analysed.

Results:

A positive correlation was found between the standardised uptake value and the size and depth of tumour infiltration, and lymph node positivity. Higher standardised uptake values were seen for more advanced tumour stages. The presence of perineural invasion, lymphatic invasion and extracapsular spread were all associated with increased standardised uptake values.

Conclusion:

Most of the clinicopathological features of head and neck carcinoma which are well known to be poor prognostic factors have a significant impact on positron emission tomography computed tomography fluorodeoxyglucose standardised uptake value.

Keywords

Head And Neck NeoplasmsComputed Tomography and Positron-Emission Tomography
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 7 , July 2013 , pp. 676 - 680
Copyright
Copyright © JLO (1984) Limited 2013 

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Footnotes

Presented at the American Academy of Otolaryngology–Head and Neck Surgery Meeting, 28 September 2010, Boston, Massachusetts, USA

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