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Acromegaly—the mucosal changes within the nose and paranasal sinuses

Published online by Cambridge University Press:  29 June 2007

D. W. Skinner  and
S. H. Richards
D. W. Skinner*
Affiliation:
The Department of Otolaryngology, The University Hospital of Wales, Health Park, Cardiff.
S. H. Richards
Affiliation:
Cardiff
*
D. W. Skinner, The Department of Otolaryngology, The University Hospital, Queen's Medical Centre, Nottingham.
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Abstract

The presence of upper respiratory tract obstruction in patients with acromegaly has been described. The main sites for obstruction were previously thought to be laryngeal and oropharyngeal. This reviews 65 patients with acromegaly and 27 patients with a prolactinoma treated by trans-ethmoidal hypophysectomy. The results confirmed a very high incidence of polyp formation and mucosal hypertrophy within both the sphenoid (88 per cent) and ethmoidal (62 per cent) sinuses of the acromegalic patients. The histological appearances of the mucosal hypertrophy and polyposis confirmed no specific features attributable to acromegaly. Patient age and serum H.G.H. level do not appear to be significance factors. These findings within the para-nasal sinuses have never previously been reported.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 102 , Issue 12 , December 1988 , pp. 1107 - 1110
Copyright
Copyright © JLO (1984) Limited 1988

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