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Role of prophylactic antibiotics in surgery for advanced head and neck cancer

Published online by Cambridge University Press:  29 June 2007

D. A. Tandon ,
S. Bahadur ,
H. C. Laldina  and
K. R. Sundaram
D. A. Tandon*
Affiliation:
New Delhi, India
S. Bahadur
Affiliation:
New Delhi, India
H. C. Laldina
Affiliation:
New Delhi, India
K. R. Sundaram
Affiliation:
New Delhi, India
*
D. A. Tandon, Department of Otolaryngology, All Indian Institute of Medical Sciences, New Delhi 110029, India.
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Abstract

Four regimens of prophylactic antibiotics were utilized in 122 consecutive patients of stages III and IV carcinoma of the upper aero-digestive tract undergoing major resections in a randomized single-blind study. Ampicillin, gentamicin, cephalexin and metronidazole were used in different combinations for periods of 5 or 10 days. A cephalexin-metronidazole protocol for 10 days was associated with lowest post-operative infection rate. Oral-oropharyngeal resection and use of pectoralis major myocutaneous flap were the most important factors contributing to infection.

Keywords

AntibioticsHead and neck neoplasmsCephalexinmetronidazole
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 7 , July 1992 , pp. 621 - 624
Copyright
Copyright © JLO (1984) Limited 1992

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References

Becker, G. D., Parell, G. J., Busch, D. E, Finegold, S. M., Acquarelli, M. J., Citron, D. M. (1980) The non-value of pre-operative and intraoperative cultures in predicting bacteriology of subsequent wound infection in patients undergoing major head and neck surgery. Laryngoscope, 90: 1933–1940.CrossRefGoogle Scholar
Brown, B. M, Johnson, J. T., Wagner, R. L. (1987) Etiological factors in head and neck wound infection. Laryngoscope, 98: 587–590.CrossRefGoogle Scholar
Chodak, G. W., Plant, M. E. (1977) Use of systemic antibiotics for prophylaxis in surgery. Archives of Surgery. 112: 326–334.CrossRefGoogle ScholarPubMed
Cummings, C. W., Johnson, J., Chung, C. K., Sagerman, R. (1977) Complications of laryngectomy and neck dissection following planned pre-operative radiotherapy. Annals of Otology, Rhinology and Laryngology, 86: 745–750.Google Scholar
Fee, W. R., Glenn, M., Handen, C, Hopp, M. L. (1984) Prophylactic antibiotics in head and neck surgery. Laryngoscope, 94: 612–614.Google Scholar
Finegold, S. M. (1980) Metronidazole. Annals of Internal Medicine, 93: 585–587.CrossRefGoogle ScholarPubMed
Johnson, J. T., Myers, E. N., Thearle, P. B. (1984) Antimicrobial prophylaxis for contaminated head and neck surgery. Laryngoscope, 94: 46–51.Google Scholar
Kaiser, A. B. (1986) Antimicrobial prophylaxis in surgery. New England Journal of Medicine, 30: 315; 1129–1138.Google Scholar
Mantravadi, R. V, Skolnik, E. M., Applebaum, E. M. (1981) Complications of post-operative and pre-operative radiotherapy in head and neck cancers. Archives of Otolaryngology, 107: 690–693.CrossRefGoogle Scholar
Piccart, M, Dor, P., Klastersky, J. (1983) Antimicrobial prophylaxis of infections in head and neck surgery. Scandinavian Journal of Infectious Diseases, Suppl 39: 92–96.Google Scholar
Polk, H. C., Mayor, J. F. (1969) Post-operative wound infections: a prospective study of determinant factors and prevention. Surgery, 66: 97–103.Google Scholar
Robbins, K. T, Byers, R. M., Cole, R., Fainstein, V., Guilamondegui, O. M, Schantz, S. P., Weber, R. S., Wolf, P., Goepfert, H. (1988) Metronidazole prophylaxis in head and neck oncology. Laryngoscope, 98: 803–806.CrossRefGoogle Scholar
Rubin, J., Johnson, J. T, Wagner, R. L., Yu, V. L. (1988) Bacteriologic analysis of wound infection following major head and neck surgery. Archives of Otolaryngology, 114: 969–972.Google Scholar
Sawyer, R. (1988) Clinical implications of metronidazole antianaerobic prophylaxis in major head and neck surgical practice. Ear, Nose and Throat Journal, 67: 655–662.Google Scholar
Seagle, M. B., Duberstein, L. E., Gross, C. W, Fletcher, J. L., Mustafa, A. Q. (1978) Efficacy of cefazolin as a prophylactic antibiotic in head and neck surgery. Otolaryngology–Head and Neck Surgery, 86: 568–572.CrossRefGoogle ScholarPubMed