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Oral Mycostatin as a possible alternative treatment for intractable Ménière's disease: preliminary cohort study

Published online by Cambridge University Press:  19 March 2014

A C Leong ,
D D Pothier  and
J A Rutka
A C Leong*
Affiliation:
Department of Otology and Neurotology, Toronto General Hospital, Canada
D D Pothier
Affiliation:
Department of Otology and Neurotology, Toronto General Hospital, Canada
J A Rutka
Affiliation:
Department of Otology and Neurotology, Toronto General Hospital, Canada
*
Address for correspondence: Dr A Leong, Department of Otology and Neurotology, Toronto General Hospital, University Health Network, Toronto, Ontario M5G 2C4, Canada E-mail: [email protected]
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Abstract

Background:

The potential efficacy of antifungal agents (e.g. Mycostatin) in treating acute attacks of Ménière's disease was first suggested in 1983 but few data have been published. Oral Mycostatin has been used as second-line medical treatment for intractable Ménière's disease at our institution for many years.

Objective:

This preliminary cohort study investigated the role of oral Mycostatin in intractable Ménière's disease.

Methods:

A retrospective review of patients with intractable Ménière's disease who started oral Mycostatin treatment between 2010 and 2012 was conducted.

Results:

Of 256 patients presenting with vertiginous disorders, 26 had definite Ménière's disease and had not responded to standard first-line treatment. Following oral Mycostatin treatment, improvements were reported for vertigo (n = 8), aural fullness (n = 7), tinnitus (n = 3) and subjective hearing loss (n = 3). Half of those with symptom improvement persisted with oral Mycostatin for two years and continued to remain asymptomatic.

Conclusion:

The use of oral Mycostatin to alleviate symptoms of intractable Ménière's disease showed promising results in this case series. Mycostatin may offer a safe and useful alternative for the management of Ménière's disease for patients with chronic unremitting symptoms in whom first-line treatment options have failed.

Keywords

Antifungal AgentsMeniere DiseaseNystatin
Type
Short Communication
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 4 , April 2014 , pp. 379 - 380
Copyright
Copyright © JLO (1984) Limited 2014 

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References

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