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Is there any effect of neurotrophin-3 on the pathogenesis of non-allergic nasal polyps?

Published online by Cambridge University Press:  05 July 2018

O Ismi ,
T Kara ,
G Polat ,
O Bobusoglu ,
Y Vayısoglu ,
K Gorur  and
C Ozcan
O Ismi*
Affiliation:
Department of Otorhinolaryngology, University of Mersin, Turkey
T Kara
Affiliation:
Department of Pathology, University of Mersin, Turkey
G Polat
Affiliation:
Department of Biochemistry, Faculty of Medicine, University of Mersin, Turkey
O Bobusoglu
Affiliation:
Department of Biochemistry, Faculty of Medicine, University of Mersin, Turkey
Y Vayısoglu
Affiliation:
Department of Otorhinolaryngology, University of Mersin, Turkey
K Gorur
Affiliation:
Department of Otorhinolaryngology, University of Mersin, Turkey
C Ozcan
Affiliation:
Department of Otorhinolaryngology, University of Mersin, Turkey
*
Author for correspondence: Dr Onur Ismi, Mersin Üniversitesi Tıp Fakültesi Hastanesi, Kulak Burun Boğaz AD, Çiftlikköy Kampüsü, Çiftlikköy/Yenişehir, Mersin, Turkey Fax: +90 3242 380 091 E-mail: [email protected]
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Abstract

Background

Although the role of neurotrophins such as nerve growth factor and brain-derived neurotrophic factor in nasal polyps development has been studied, the contribution of neurotrophin-3 has not been evaluated yet. This study aimed to investigate the possible role of neurotrophin-3 in nasal polyps pathogenesis.

Methods

The study group comprised 70 non-allergic nasal polyps patients and the control group consisted of 53 patients with middle turbinate concha bullosa. Specimens were taken, during surgery, from the ethmoid sinus nasal polyps in the nasal polyps group and from the lateral part of the middle turbinate concha bullosa in the control group. Tissue and serum levels of neurotrophin-3 were assessed by immunohistochemistry and enzyme-linked immunosorbent assay, respectively.

Results

Nasal polyps patients had higher tissue neurotrophin-3 scores (p < 0.001). There was no statistically significant difference between groups regarding serum neurotrophin-3 levels (p = 0.417). Tissue neurotrophin-3 staining scores in the nasal polyps group had no statistically significant correlation with Lund–Mackay scores (p = 0.792).

Conclusion

Neurotrophin-3 may have a local effect in nasal polyps pathogenesis, without joining systemic circulation.

Keywords

Nasal PolypsNeurotrophin 3Inflammation
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 8 , August 2018 , pp. 724 - 728
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr O Ismi takes responsibility for the integrity of the content of the paper

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