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Intratympanic injection with dexamethasone for sudden sensorineural hearing loss

Published online by Cambridge University Press:  05 November 2010

Y-J Tsai ,
J-G Liang ,
W-B Wu ,
Y-F Ding ,
R P-Y Chiang  and
S-M Wu
Y-J Tsai
Affiliation:
Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan
J-G Liang
Affiliation:
Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan Department of Otolaryngology, Puli Christian Hospital, Nantou, Taiwan
W-B Wu
Affiliation:
School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan
Y-F Ding
Affiliation:
Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan
R P-Y Chiang*
Affiliation:
Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan Department of Otolaryngology Head and Neck Surgery, School of Medicine, Fu-Jen Catholic University, Taipei, Taiwan
S-M Wu
Affiliation:
Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan
*
Address for correspondence: Dr Rayleigh Ping-Ying Chiang, Department of Otolaryngology, Shin-Kong Wu-Ho-Su Memorial Hospital, 95 Wen Chang Road, Shih Lin District, Taipei City, Taiwan Fax: +886 2 25463179 E-mail: [email protected]
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Abstract

Objective:

To investigate the efficacy of intratympanic steroid therapy in adults with sudden sensorineural hearing loss, and to analyse the factors associated with treatment outcome.

Design:

Retrospective study of patients undergoing intratympanic steroid injection for sudden sensorineural hearing loss between 1 January 2006 and 30 June 2007 at a teaching hospital in Taipei, Taiwan.

Results:

Patients who received intratympanic steroid therapy within seven days of disease onset achieved a significantly better response rate (76.1 per cent), compared with the delayed treatment group (50 per cent). The total response rate, after four steroid injections, was 68.9 per cent. Patients with low and mid-frequency hearing loss were more responsive to steroid treatment. Vertigo was a negative prognostic factor for recovery. There were no long-term sequelae of intratympanic steroid treatment.

Conclusion:

Intratympanic steroid injection may be a simple and effective treatment for patients with sudden sensorineural hearing loss.

Keywords

Sudden Sensorineural Hearing LossDexamethasoneIntratympanic TherapyMiddle Ear
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 2 , February 2011 , pp. 133 - 137
Copyright
Copyright © JLO (1984) Limited 2010

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Footnotes

Presented at the 85th Conference of Taiwan Otolaryngology Society, 7–8 November 2008, Taipei, Taiwan

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