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Hypoparathyroidism after the treatment of laryngopharyngeal carcinoma

Published online by Cambridge University Press:  29 June 2007

S. Mortimore ,
M. A. Thorp ,
E. L. K. Nilssen  and
S. Isaacs
S. Mortimore*
Affiliation:
Department of Otolaryngology, Groote Schuur Hospital, Cape Town, South Africa
M. A. Thorp
Affiliation:
Department of Otolaryngology, Groote Schuur Hospital, Cape Town, South Africa
E. L. K. Nilssen
Affiliation:
Department of Otolaryngology, Groote Schuur Hospital, Cape Town, South Africa
S. Isaacs
Affiliation:
Medical Informatics Department, Groote Schuur Hospital, Cape Town, South Africa
*
Address for correspondence: Mr S. Mortimore, Department of Otorhinolaryngology, Royal Liverpool University Hospital, Daulby Street, Liverpool, L69 3GA
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Abstract

Thirty patients with squamous cell carcinoma of the laryngopharynx were treated with surgery (total laryngectomy and hemithyroidectomy) and radiotherapy. Group 1 (n = 7) patients had surgery only; Group 2 (n = 7) had radiotherapy followed by salvage surgery while Group 3 (n = 16) had surgery followed by radiotherapy.

Parathyroid hormone and calcium levels were measured pre- and post-operatively and pdstradiotherapy. In Group 1 no patients were hypoparathyroid. In Group 2, 29 per cent of patients preoperatively and 57 per cent post-operatively, were hypoparathyroid. In Group 3, no patients were hypoparathyroid pre-operatively, while 25 per cent were hypoparathyroid post-operatively and postradiotherapy. Parathyroid honnone and calcium levels were averaged and compared within and between each group. There was no significant difference within each group, when comparing levels postoperatively and post-radiotherapy from those of pre-operatively. There was no significant difference in levels between each of Groups 1, 2 or 3 (p>0.05).

Keywords

Hypoparathyroidism, Radiotherapy, Surgery, operativeLaryngectomy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 11 , November 1998 , pp. 1058 - 1060
Copyright
Copyright © JLO (1984) Limited 1998

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Footnotes

Presented at the 1996 Combined 3rd Scientific Meeting of the Pan African Federation of Otolaryngological Societies and the 32nd Annual Academic Meeting of the South African Society of Otorhinolaryngology, Head and Neck Surgery Congress.

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