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Development of cavernous haemangioma following radical chemo-radiotherapy for nasopharyngeal carcinoma

Published online by Cambridge University Press:  08 March 2017

J R Ellenbogen
Affiliation:
Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, UK
S M Joshi
Affiliation:
Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, UK
N Kitchen*
Affiliation:
Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, London, UK
*
Address for correspondence: Mr N Kitchen, Consultant Neurosurgeon, The National Hospital for Neurology & Neurosurgery, London, WC1N 3BG, UK. E-mail: [email protected]

Abstract

Objective:

We report an adult case of nasopharyngeal carcinoma treated with radical chemo-radiotherapy, with subsequent development of a histologically proved temporal cavernous haemangioma within the radiation field.

Method:

Case report and review of the current literature concerning radiation-induced, secondary, space-occupying lesions.

Conclusion:

The increasing role of radiotherapy in nasopharyngeal carcinoma treatment, together with improved patient survival, is likely to lead to radiation-induced, secondary, space-occupying lesions being encountered more frequently. We emphasise the need to be vigilant for this important but relatively rare complication, which has significant associated morbidity.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 2008

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References

1 Jeyakumar, A, Brickman, TM, Jeyakumar, A, Doerr, T. Review of nasopharyngeal carcinoma. Ear Nose Throat J 2006;85:168–74CrossRefGoogle ScholarPubMed
2 King, AD, Ahuja, AT, Teo, P, Tse, GMK, Kew, J. Radiation induced sarcomas of the head and neck following radiotherapy for nasopharyngeal carcinoma. Clin Radiol 2000;55:684–9CrossRefGoogle ScholarPubMed
3 Cheng, KM, Chan, CM, Fu, YT, Ho, YW, Tsang, YW, Lee, MK et al. Brain abscess formation in radiation necrosis of the temporal lobe following radiation therapy for nasopharyngeal carcinoma. Acta Neurochir (Wien) 2000;142:435–41CrossRefGoogle ScholarPubMed
4 Goh, YH, Chong, VF, Low, WK. Temporal bone tumours in patients irradiated for nasopharyngeal neoplasms. J Laryngol Otol 1999;113:222–8CrossRefGoogle Scholar
5 Kong, L, Lu, JJ, Hu, C, Guo, X, Wu, Y, Zhang, Y. The risk of secondary primary tumors in patients with nasopharyngeal carcinoma after definitive radiotherapy. Cancer 2006;107:1287–93CrossRefGoogle Scholar
6 Nimjee, SM, Power, CJ, Bulsara, KR. Review of the literature on de novo formation of cavernous malformations of the central nervous system after radiation therapy. Neurosurg Focus 2006;21:16CrossRefGoogle ScholarPubMed
7 Burn, S, Gunny, R, Phipps, K, Gaze, M, Haywood, R. Incidence of cavernoma development in children after radiotherapy for brain tumors. J Neurosurg 2007;106:379–83Google ScholarPubMed
8 Baumgartner, JE, Ater, JL, Ha, CS, Kuttesch, JF, Leeds, NE, Fuller, GN et al. Pathologically proven cavernous angiomas of the brain following radiation therapy for pediatric brain tumours. Pediatr Neurosurg 2003;39:201–7CrossRefGoogle Scholar
9 Amirjamshidi, A, Abbassioun, K. Radiation-induced tumors of the central nervous system occurring in childhood and adolescence. Childs Nerv Syst 2000;16:390–7CrossRefGoogle ScholarPubMed
10 Robinson, JR, Awad, IA, Little, JR. Natural history of the cavernous angioma. J Neurosurg 1991;75:709–14CrossRefGoogle ScholarPubMed
11 Curling, OD, Kelly, DL, Elster, AD, Craven, TE. An analysis of the natural history of cavernous angiomas. J Neurosurg 1991;75:702–8CrossRefGoogle ScholarPubMed
12 Furuse, M, Miyatake, SL, Kuroiwa, T. Cavernous malformation after radiation therapy for astrocytoma in adult patients: report of 2 cases. Acta Neurochir (Wien) 2005;147:1097–101CrossRefGoogle Scholar
13 Heckl, S, Achoff, A, Kunze, S. Radiation-induced cavernous hemangiomas of the brain. Cancer 2002;94:3285–91CrossRefGoogle ScholarPubMed
14 Gaensler, EH, Dillon, WP, Edwards, MS, Larson, DA, Rosenau, W, Wilson, CB. Radiation-induced telangiectasia in the brain simulates cryptic vascular malformations at MR imaging. Radiology 1994;193:629–36CrossRefGoogle ScholarPubMed