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Factors affecting the acquisition of resistance against Schistosoma mansoni in the mouse. 2. The time at which resistance to reinfection develops

Published online by Cambridge University Press:  05 June 2009

E. Long ,
M. Doenhoff  and
J. Bain
E. Long
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St. Albans, AL4 0XQ, England
M. Doenhoff
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St. Albans, AL4 0XQ, England
J. Bain
Affiliation:
Department of Medical Helminthology, London School of Hygiene and Tropical Medicine, Winches Farm Field Station, 395 Hatfield Road, St. Albans, AL4 0XQ, England
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Abstract

Mice developed a partial resistance against homologous challenge with Schistosoma mansoni as early as two weeks after primary infections of 35 to 75 cercariae, and the degree of protection increased to an apparent maximum by 6 weeks. Animals given a primary infection of only 25 cercariae required a longer period to acquire maximum resistance.

Type
Research Papers
Information
Journal of Helminthology , Volume 52 , Issue 3 , September 1978 , pp. 187 - 191
Copyright
Copyright © Cambridge University Press 1978

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References

REFERENCES

Capron, A., Biguet, J., Rose, F. and Vernes, A. (1965) Les antigènes de Schistosoma mansoni: II. Annales de l'Institute Pasteur, 109, 798–810.Google ScholarPubMed
Erickson, D. G. and Caldwell, W. L. (1965) Acquired resistance in mice and rate after exposure to gamma-irradiated cercariae. American Journal of Tropical Medicine and Hygiene, 14, 566–573.CrossRefGoogle Scholar
Foster, R. and Broomfield, K. E. (1971) Preliminary studies on the development of Schistosoma mansoni in rhesus monkeys following different regimens of infection. Annals of Tropical Medicine and Parasitology, 65, 367–384.CrossRefGoogle ScholarPubMed
Hunter, G. W., Crandall, R. B., Zickafoose, D. E. and Purvis, Q. B. (1962) Studies on schistosomiasis. XVIII. Some factors affecting resistance to Schistosoma mansoni infections in albino mice. American Journal of Tropical Medicine and Hygiene, 11, 17–24.CrossRefGoogle Scholar
Kagan, I. G. (1952) Acquired immunity in mice infected with Schistosomatium douthitti. Journal of Infectious diseases, 91, 147–158.CrossRefGoogle ScholarPubMed
Lightenberg, F. von, Sadun, E. H. and Bruce, J. I. (1963) Host response to eggs of Schistosoma mansoni. III. The rôle of eggs in resistance. Journal of Infectious Diseases, 113, 113–122.CrossRefGoogle Scholar
Moore, D. V., Crandall, R. B. and Hunter, G. W. (1963) Studies on schistosomiasis. XX. Further studies on the immunogenic significance of Schistosoma mansoni eggs in albino mice when subjected to homologous challenge. Journal of Parasitology, 49, 117–120.CrossRefGoogle Scholar
Radke, M. G. and Sadun, E. H. (1963) Resistance produced in mice by exposure to irradiated Schistosoma mansoni cercariae. Experimental Parasitology, 13, 134–142.CrossRefGoogle Scholar
Ritchie, L. S., Knight, W. B., McMullen, D. B. and Lichtenberg, F. von (1966) The influence of infection intensity of Schistosoma mansoni on resistance against existing and subsequent infection in Macaca mulatta. American Journal of Tropical Medicine and Hygiene, 15, 43–49.CrossRefGoogle ScholarPubMed
Sadun, E. H., Schoenbechler, M. J. and Bentz, M. (1965) Multiple antibody response in Schistosoma mansoni infections. American Journal of Tropical Medicine and Hygiene, 14, 977–995.CrossRefGoogle ScholarPubMed
Sher, A., Mackenzie, P. and Smithers, S. R. (1974) Decreased recovery of invading parasites from the lungs as a parameter of acquired immunity to schistosomiasis in the mouse. Journal of Infectious Diseases, 130, 626–633.CrossRefGoogle ScholarPubMed
Smithers, S. R. (1962) Stimulation of acquired resistance to Schistosoma mansoni in monkeys: Role of eggs and worms. Experimental Parasitology, 12, 263–273.CrossRefGoogle ScholarPubMed
Smithers, S. R. and Terry, R. J. (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adult worms. Parasitology, 55, 695–700.CrossRefGoogle ScholarPubMed
Smithers, S. R. and Terry, R. J. (1967) Resistance to experimental infection with Schistosoma mansoni in rhesus monkey induced by the transfer of adult worms. Transactions of the Royal Society of Tropical Medicine and Hygiene, 61, 517–533.CrossRefGoogle Scholar
Villella, J. B., Gomberg, H. J. and Gould, S. E. (1961) Immunization to Schistosoma mansoni developed from gamma-irradiated cercariae. Science, 134, 1073–1074.CrossRefGoogle Scholar